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    Original Article| Open Access

    Secondary malignancy estimation in patients after mastectomy and adjuvant therapy

    Oludare Folajimi Adeyemi, Okhuomaruyi David Osahon, Enosakhare Godwin Okungbowa

    Aim: Secondary malignancy estimation after radiotherapy of post mastectomy patients is becoming an important subject for comparative treatment planning. The data from modern treatment planning systems provide accurate three-dimensional dose distributions for each individual patients, thereby... Read more

    J Cancer Metastasis Treat 2018;4:53. | doi:10.20517/2394-4722.2018.12
    Published on: 8 Oct 2018  | Viewed:257  | Downloaded:19
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    Perspective| Open Access

    Pharmacogenetics and cancer management

    Harish Padh

    The science of one’s genetic background and its impact on disease susceptibility and drug response has come of age and firmly established its proper place in the clinic. Its impact is felt more in the treatment of cancer than any other disease area several reasons: critical time, narrow... Read more

    This article belongs to the Special Issue Cancer Pharmacogenomics J Cancer Metastasis Treat 2018;4:52. | doi:10.20517/2394-4722.2018.51
    Published on: 29 Sep 2018  | Viewed:202  | Downloaded:11
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    Original Article| Open Access

    Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression

    Jessica Felton, Kunrong Cheng, Aaron C. Shang, Shien Hu, Shannon M. Larabee, Cinthia B. Drachenberg, Jean-Pierre Raufman

    Aim: Strong evidence reveals important differences between cancers in the proximal vs. distal colon. Animal models of metastatic colon cancer are available but with varying degrees of reproducibility and several important limitations. We explored whether there were regional differences in the... Read more

    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment J Cancer Metastasis Treat 2018;4:51. | doi:10.20517/2394-4722.2018.39
    Published on: 27 Sep 2018  | Viewed:212  | Downloaded:13
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    Case Report| Open Access

    Cryptic NUP214-ABL1 fusion with complex karyotype, episomes and intra-tumor genetic heterogeneity in a T-cell lymphoblastic lymphoma

    Moneeb A.K Othman, Beate Grygalewicz, Agnieszka Kołkowska-Leśniak, Joana B. Melo, Isabel M. Carreira, Thomas Liehr

    T-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin’s lymphoma and little is known about their molecular background. However, complex karyotypes were already related to this group of malignancy and associated with poor outcome. Here, we describe a 17-year-old female... Read more

    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity J Cancer Metastasis Treat 2018;4:50. | doi:10.20517/2394-4722.2018.41
    Published on: 21 Sep 2018  | Viewed:421  | Downloaded:23
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    Review| Open Access

    NSAID celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

    Stephen John Ralph, Sam Nozuhur, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez, Rhys Pritchard

    Intermittent hypoxia within tumor microenvironments causes pro-oxidative stress impairing oxidative phosphorylation (OxPhos) and increases mitochondrial production of reactive oxygen species (ROS). In primary tumors this provokes metabolic reprogramming of both tumor cells and cancer stem cells... Read more

    J Cancer Metastasis Treat 2018;4:49. | doi:10.20517/2394-4722.2018.42
    Published on: 20 Sep 2018  | Viewed:683  | Downloaded:48
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    Editorial| Open Access

    Introduction to the special issue on reviews of gastric cancer metastasis and treatment

    Masayuki Watanabe This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:48. | doi:10.20517/2394-4722.2018.60
    Published on: 17 Sep 2018  | Viewed:227  | Downloaded:19
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    Review| Open Access

    Unmasking tumor heterogeneity and clonal evolution by single-cell analysis

    Xiaoshan Shi, Papia Chakraborty, Amitabha Chaudhuri

    The intratumoral heterogeneity orchestrated by the tumor intrinsic and extrinsic mechanisms enable cancers to persist and spread notwithstanding the use of aggressive interventional therapies. The heterogeneity is revealed at multiple levels - at the level of individual tumor cells, in the... Read more

    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity J Cancer Metastasis Treat 2018;4:47. | doi:10.20517/2394-4722.2018.32
    Published on: 31 Aug 2018  | Viewed:1354  | Downloaded:125
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    Original Article| Open Access

    Increased ARF6 activation correlates with HGF stimulation in non-invasive prostate cancer cells

    Claire Morgan, Lucy J. Swithenbank, Helen Whiteland, Shareen H. Doak

    Aim: The effects of hepatocyte growth factor (HGF) on a non-invasive prostate cancer cell line (CAHPV-10), expressing cMET were studied, to mimic the possible effects neo-adjuvant androgen deprivation therapy may have in promoting tumour progression. Methods: Prostate epithelial cells and... Read more

    J Cancer Metastasis Treat 2018;4:46. | doi:10.20517/2394-4722.2018.19
    Published on: 30 Aug 2018  | Viewed:543  | Downloaded:104
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    Editorial| Open Access

    Introduction of the special issue “How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?”

    Jason P. Webber, Klaus Pors This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome? J Cancer Metastasis Treat 2018;4:45. | doi:10.20517/2394-4722.2018.46
    Published on: 21 Aug 2018  | Viewed:435  | Downloaded:133
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    Review| Open Access

    Expression and regulation of aldehyde dehydrogenases in prostate cancer

    Ali I. M. Ibrahim, Maria Sadiq, Fiona M. Frame, Norman J. Maitland, Klaus Pors

    The functional role of aldehyde dehydrogenases (ALDHs) in prostate cancer remains an area of some controversy. Many studies have used high ALDH functional activity to isolate putative cancer stem cells with tumour-initiating and propagating properties, while evidence is also emerging about the... Read more

    This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome? J Cancer Metastasis Treat 2018;4:44. | doi:10.20517/2394-4722.2018.07
    Published on: 21 Aug 2018  | Viewed:790  | Downloaded:139
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