Most Viewed: Last ONE YEAR
  • Review|Open Access

    DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression

    Wei Wang , Arul M. Mani , Zhao-Hui Wu
    DNA damage is a vital challenge to cell homeostasis. Cellular responses to DNA damage (DDR) play essential roles in maintaining genomic stability and survival, whose failure could lead to detrimental consequences such as cancer development and aging. Nuclear factor-kappa B (NF-kB) is a family of transcription factors that plays critical roles in cellular stress response. Along with p53, NF-kB modulates transactivation of a large number of genes which participate in various cellular processes involved in DDR. Here the authors summarize the recent progress in understanding DNA damage response... Read more
    J Cancer Metastasis Treat 2017;3:45-59. | doi:10.20517/2394-4722.2017.03
    Published on: 27 Mar 2017  | Viewed:3044  | Downloaded:157
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  • Topic: Cancer Immunotherapy|Open Access

    Cancer immunotherapy: a brief review of the history, possibilities, and challenges ahead

    Stanley J. Oiseth , Mohamed S. Aziz
    The knowledge that the body possesses natural defenses to combat cancer existed long before the modern period, with multiple anecdotal reports of tumors miraculously disappearing, sometimes spontaneously or after a febrile or infectious episode. Spontaneous tumor regression of untreated malignant tumors is currently a well-accepted albeit rare phenomenon, and it is recognized that immunosuppression is associated with a higher cancer risk. The treatment of bladder carcinoma by intravesical administration of live attenuated Bacillus Calmette-Guérin bacteria was shown to be very effective in... Read more
    J Cancer Metastasis Treat 2017;3:250-61. | doi:10.20517/2394-4722.2017.41
    Published on: 31 Oct 2017  | Viewed:2915  | Downloaded:1012
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    A versatile method for enumeration and characterization of circulating tumor cells from patients with breast cancer

    Ujjwala M. Warawdekar , Vani Parmar , Aruna Prabhu , Abhay Kulkarni , Meenal Chaudhari , Rajendra A. Badwe
    Aim: To establish a standardized protocol for the isolation and enumeration of circulating tumor cells (CTCs) from peripheral blood of patients with metastatic breast cancer. Methods: The protocol used tumor cells spiked in a lymphoid cell line with detection by flow cytometry and quantitative reverse transcription polymerase chain reaction (QRT-PCR). Cells of the human mammary cancer subtypes were spiked into Jurkat cells, which served as the lymphocyte designate in numbers from 10 to 500 per 105 Jurkat cells. This mixed population was probed for CD45, EpCAM, and pancytokeratin acquired... Read more
    J Cancer Metastasis Treat 2017;3:23-33. | doi:10.20517/2394-4722.2016.66
    Published on: 23 Feb 2017  | Viewed:2434  | Downloaded:133
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  • Commentary|Open Access

    A new twist to neurotransmitter receptors and cancer

    Hildegard M. Schuller
    J Cancer Metastasis Treat 2017;3:71-7. | doi:10.20517/2394-4722.2017.18
    Published on: 28 Apr 2017  | Viewed:2082  | Downloaded:123
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  • Original Article|Open Access

    Real-time quantitative PCR array to study drug-induced changes of gene expression in tumor cell lines

    Stefano Amatori , Giuseppe Persico , Mirco Fanelli
    Aim: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is still the “gold standard” for quantitative analysis of mRNA and the study of differentially expressed genes. Methods: The authors describe a RT-qPCR array that exploits SYBR Green dye-based detection to perform reliable gene expression analysis on 41 genes involved in several pathways linked to DNA damage response, cell cycle progression, cellular senescence, and programmed cell death. To validate the RT-qPCR array, the authors investigated changes of the gene expression profile of HeLa cells treated with two... Read more
    J Cancer Metastasis Treat 2017;3:90-9. | doi:10.20517/2394-4722.2017.22
    Published on: 24 May 2017  | Viewed:2071  | Downloaded:150
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  • Review|Open Access

    Role of adenosine in tumor progression: focus on A2B receptor as potential therapeutic target

    Claudia Sorrentino , Silvana Morello
    Adenosine receptors are a family of G-coupled receptors which mediate the anti-inflammatory and immune-suppressive effects of adenosine in a damaged tissue. A large number of evidence indicate that the accumulation of adenosine under hypoxic conditions favors tumor progression, helping cancer cells to evade immune responses. Tumor cells and/or lymphoid and myeloid cells can express the adenosine-generating enzyme CD73 and/or A2A receptor, which in turn strongly suppresses an effective T-cell-mediated response, while promotes the activity of suppressive cells such as Treg and myeloid-derived... Read more
    J Cancer Metastasis Treat 2017;3:127-38. | doi:10.20517/2394-4722.2017.29
    Published on: 17 Jul 2017  | Viewed:1901  | Downloaded:225
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Profiling of circulating tumor cells in liquid biopsies from metastatic cancer patients

    Pravin D. Potdar , Keerti Sen
    Aim: Circulating tumor cells (CTCs) are crucial to tumor metastasis and valuable for prediction of clinical outcome in patients with solid tumors. Here, the authors aimed to establish a method for enumeration and characterization of CTCs from liquid biopsies. Methods: Peripheral blood mononuclear cells (PBMCs) were separated from blood samples from patients with metastatic cancer using Ficoll-Hypaque gradients and cultured to isolate and enumerate CTCs. Cultured CTCs were morphologically characterized by light and phase contrast microscopy. The tumorigenicity of Ficoll-Hypaque-separated... Read more
    J Cancer Metastasis Treat 2017;3:6-15. | doi:10.20517/2394-4722.2016.53
    Published on: 23 Jan 2017  | Viewed:1727  | Downloaded:149
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  • Review|Open Access

    Cytogenetic and molecular basis of BCR-ABL myelodysplastic syndrome: diagnosis and prognostic approach

    Mostafa Paridar , Omid Kiani Ghalesardi , Mohammad Seghatoleslami , Ahmad Ahmadzadeh , Abbas Khosravi , Najmaldin Saki
    Myelodysplastic syndromes (MDS) include a heterogeneous group of blood disorders generally afflicting older people. Several genetic factors have been reported from these patients that have an important role in the diagnosis, prognosis, and treatment of this disease. BCR-ABL1 is a genetic factor that has occasionally been reported in some studies. This review attempts to characterize MDS patients reported to harbor this fusion and to assess the diagnostic, therapeutic, and prognostic potential of BCR-ABL1 fusionin MDS patients. This review showed that BCR-ABL fusion has been reported in 22... Read more
    J Cancer Metastasis Treat 2017;3:38-44. | doi:10.20517/2394-4722.2016.61
    Published on: 28 Feb 2017  | Viewed:1460  | Downloaded:154
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  • Original Article|Open Access

    TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells

    Maozhen Tian , William P. Schiemann
    Aim: Estrogen receptor-α (ER-α) activation drives the progression of luminal breast cancers. Signaling by transforming growth factor-β (TGF-β) typically opposes the actions of ER-α; it also induces epithelial-mesenchymal transition (EMT) programs that promote breast cancer dissemination, stemness and chemoresistance. The impact of EMT programs on nongenomic ER-α signaling remains unknown and was studied herein. Methods: MCF-7 and BT474 cells were stimulated with TGF-β to induce EMT programs, at which point ER-α expression, localization, and nongenomic interactions with receptor tyrosine... Read more
    J Cancer Metastasis Treat 2017;3:150-60. | doi:10.20517/2394-4722.2017.38
    Published on: 21 Aug 2017  | Viewed:1449  | Downloaded:99
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  • Original Article|Open Access

    Papaya black seeds have beneficial anticancer effects on PC-3 prostate cancer cells

    Khalid S. Alotaibi , Haiwen Li , Reza Rafi , Rafat A. Siddiqui
    Aim: The study investigated the effect of papaya seeds on prostate cancer (PC) using PC-3 cell line because papaya seeds have effects on the male reproductive system notably decreasing sperm concentration, motility, and viability, leading to azoospermia after short-to-long-term treatment. Methods: The black seeds from yellow (ripe) papaya and white seeds from green (unripe) papaya were harvested and then extracted in water, 80% methanol, and hexane. The cytotoxic effects of seeds extracts were determined using a WST-1 proliferation assay. The amount of total polyphenols was determined using... Read more
    J Cancer Metastasis Treat 2017;3:161-8. | doi:10.20517/2394-4722.2017.33
    Published on: 28 Aug 2017  | Viewed:1392  | Downloaded:96
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    Prostate cancer exosomes as modulators of the tumor microenvironment

    Alex P. Shephard , Vincent Yeung , Aled Clayton , Jason P. Webber
    Researchers are currently trying to understand why some men with prostate cancer go on to develop aggressive disease whilst others maintain slow growing tumors. Although endogenous genetic anomalies within the tumor cell are important, the prevailing view is that the tissue microenvironment as a whole is the determinant factor. Many studies have focussed on the role of soluble factors in modulating the nature of the tumor microenvironment. There is however a growing interest in the role of extracellular vesicles, including exosomes, as regulators of disease progression. A variety of... Read more
    J Cancer Metastasis Treat 2017;3:288-301. | doi:10.20517/2394-4722.2017.32
    Published on: 6 Dec 2017  | Viewed:1301  | Downloaded:97
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Lung cancer biopsy dislodges tumor cells into circulating blood

    Noriyoshi Sawabata , Tomotaka Kitamura , Yuko Nitta , Tomoyo Taketa , Takeshi Ohno , Tatsuya Fukumori , Takeru Hyakutake , Takahito Nakamura
    Aim: A “seed” of lung cancer metastasis is circulating tumor cells (CTCs), which may be dislodged from a tumor during biopsy. This possibility was assessed among patients who underwent lung tumor biopsy using flexible fiber-topic bronchoscopy (FFB). Methods: The study involved six patients with non-small cell lung cancer who underwent FFB biopsy to diagnose a lesion pathologically (5 males and 1 female, median age 63 years, six adenocarcinomas, of four clinical-stage IA, one stage IB, and one stage IIIA), CTCs were extracted from the peripheral vein blood at pre-FFB and at post-FFB using a... Read more
    J Cancer Metastasis Treat 2017;3:16-20. | doi:10.20517/2394-4722.2016.67
    Published on: 23 Jan 2017  | Viewed:1270  | Downloaded:127
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  • Original Article|Open Access

    Combination of insulin-like growth factor-1, IGF binding protein-3, chromogranin A and prostate specific antigen can improve the detection of prostate cancer

    Saleh Ahmed Kamaleldin Saleh , Heba Mohamed Adly , Anmar Mohammed Nassir
    Aim: Prostate cancer (PCa) is the second most prevalent male cancer worldwide and designated the sixth most frequent male cancer in Arab countries. Although prostate specific antigen (PSA) has become the best and most valuable biomarker for screening of PCa, elevated levels of PSA can reflect the presence of malignant cells but can overlap with benign prostatic diseases. There is a necessity to develop and improve current tools for early detection and diagnosis of PCa. This study was done to evaluate the validation of serum insulin-like growth factor-1 (IGF-1), IGF binding protein-3... Read more
    J Cancer Metastasis Treat 2017;3:82-9. | doi:10.20517/2394-4722.2017.20
    Published on: 24 May 2017  | Viewed:1214  | Downloaded:65
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  • Original Article|Open Access

    Impact of health care insurance on overall survival of patients with multiple myeloma and monoclonal gammopathy of undetermined significance

    Srinivas S. Devarakonda , Runhua Shi , Ellen Friday , Reinhold Munker , Jonathan Glass , Francesco Turturro
    Aim: Health care insurance improves access to care and thus outcome in patients with solid tumors. Little information on the impact of health care insurance on hematological malignancies including multiple myeloma exists. The authors aimed to analyze the effect of health care insurance on the survival of patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) at Louisiana State University Health Sciences Center in Shreveport, LA. Methods: Two hundred fifty seven patients were reviewed, of which 208 had MM and 49 had MGUS. Results: One hundred and... Read more
    J Cancer Metastasis Treat 2017;3:100-4. | doi:10.20517/2394-4722.2017.19
    Published on: 9 Jun 2017  | Viewed:1151  | Downloaded:64
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  • Topic: Cancer Immunotherapy|Open Access

    Systemic humoral responses of non-muscle-invasive bladder cancer during BCG treatment: less is more

    Fernando M. Calais da Silva , Paula A. Videira , Dário Ligeiro , Maria Guadalupe Cabral , Richard Sylvester , Fernando E. Calais da Silva , Hélder Trindade
    Aim: Intravesical Bacille Calmette-Guérin (BCG) is the mainstay adjuvant treatment of non-muscle-invasive bladder cancer. However, one third of the patients on BCG regimen relapse within the first year of treatment. This study aimed at identifying biomarkers to predict response to BCG treatment. Methods: Gene expression was analyzed in blood cells of 58 patients treated with BCG through six consecutive weekly instillations and then at month 3, 6, 9, and 12. Cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-10, interferon (IFN)-γ, IL-1β, IL-2, IL-4, and IL-6; chemokines CCL2, CCL3,... Read more
    J Cancer Metastasis Treat 2017;3:116-26. | doi:10.20517/2394-4722.2017.25
    Published on: 14 Jul 2017  | Viewed:1099  | Downloaded:51
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  • Case Report|Open Access

    Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib

    Hiroto Kaneko , Kazuho Shimura , Yosuke Matsumoto , Mihoko Yoshida , Masafumi Taniwaki , Junya Kuroda
    Alkaline phosphatase (ALP) flare has been reported to occur during cancer treatment as a favorable event, particularly in the presence of bone metastasis. There have been only a few reports in lung cancer and associated radiographic findings have seldom been described. The authors observed ALP flare in a female patient with lung adenocarcinoma soon after the initiation of gefitinib. Moreover, on computed tomography, metastatic lesions of the rib and thoracic spine showed marked hyperostosis, with sizes larger than the original bone structure, suggesting efficacy of gefitinib. The... Read more
    J Cancer Metastasis Treat 2017;3:34-7. | doi:10.20517/2394-4722.2016.70
    Published on: 23 Feb 2017  | Viewed:1017  | Downloaded:72
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    Tumor heterogeneity and therapy resistance - implications for future treatments of prostate cancer

    Fiona M. Frame , Amanda R. Noble , Sandra Klein , Hannah F. Walker , Rakesh Suman , Richard Kasprowicz , Vin M. Mann , Matt S. Simms , Norman J. Maitland
    Aim: To develop new therapies for prostate cancer, disease heterogeneity must be addressed. This includes patient variation, multi-focal disease, cellular heterogeneity, genomic changes and epigenetic modification. This requires more representative models to be used in more innovative ways. Methods: This study used a panel of cell lines and primary prostate epithelial cell cultures derived from patient tissue. Several assays were used; alamar blue, colony forming assays, γH2AX and Ki67 immunofluorescence and comet assays. Ptychographic quantitative phase imaging (QPI), a label-free imaging... Read more
    J Cancer Metastasis Treat 2017;3:302-14. | doi:10.20517/2394-4722.2017.34
    Published on: 6 Dec 2017  | Viewed:944  | Downloaded:80
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  • Review|Open Access

    Using circulating tumor cells to advance precision medicine in prostate cancer

    Giuseppe Galletti , Daniel Worroll , David M. Nanus , Paraskevi Giannakakou
    The field of circulating tumor cell (CTC) enrichment has seen many emerging technologies in recent years, which have resulted in the identification and monitoring of clinically relevant, CTC-based biomarkers that can be analyzed routinely without invasive procedures. Several molecular platforms have been used to investigate the molecular profile of the disease, from high throughput gene expression analyses down to single cell biological dissection. The established presence of CTC heterogeneity nevertheless constitutes a challenge for cell isolation as the several subpopulations can... Read more
    J Cancer Metastasis Treat 2017;3:190-205. | doi:10.20517/2394-4722.2017.45
    Published on: 27 Sep 2017  | Viewed:929  | Downloaded:53
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  • Short Communication|Open Access

    Management of choroidal metastasis using external beam radiotherapy: a retrospective study and review of the literature

    Zakaria Ahmed Youbi , Enachescu Ciprian , Caraivan Ionela , Bennani Zineb , Khounigere Majdouline , Kotzki Léa , Pialat Pierre-Marie , Sesques Pierre , Yossi Séna
    Aim: Choroidal metastases are rare in the evolution of solid cancers and constitute exceptional metastatic sites involving functional visual prognosis. The authors conducted a retrospective study to determine the interest of external radiotherapy for the treatment of choroidal metastases. Methods: The authors reviewed the records of 28 patients with choroidal metastases who had breast (n = 15), lung (n = 9), ovarian (n = 1), kidney (n = 1), prostate (n = 1) cancer or carcinoma with unknown primitive at the moment of the diagnosis (n = 1). The median age was 58 years (extremes: 34-71 years).... Read more
    J Cancer Metastasis Treat 2017;3:105-10. | doi:10.20517/2394-4722.2017.07
    Published on: 30 Jun 2017  | Viewed:888  | Downloaded:90
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  • Letter to Editor|Open Access

    Use of a dedicated day care unit in a modern radiation oncology facility -- a short audit

    Tejinder Kataria , Susovan Banerjee , Nimesh Dahima , Deepak Gupta , Trinanjan Basu , Shikha Goyal
    J Cancer Metastasis Treat 2017;3:21-2. | doi:10.20517/2394-4722.2016.73
    Published on: 23 Jan 2017  | Viewed:877  | Downloaded:72
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  • Original Article|Open Access

    Expression of PANDA, LincRNA-p21, PUMA in lung tissues of lung cancer patients in the Xuanwei and non-Xuanwei areas of Yunnan Province

    Kai-Yun Yang , Zhi-Qiang Shen , Yue-Feng He , Kushal Rizal , Hui Tan , An-Ning Chen , Yun-Chao Huang , Guang-Qiang Zhao , Yu-Jie Lei
    Aim: To study the expression of PANDA, LincRNA-p21, and PUMA in lung tissue of patients with lung cancer from Xuanwei of Yunnan Province. Methods: Forty-five cases of lung cancer patients from Xuanwei and 42 lung cancer cases from non-Xuanwei were enrolled. Extraction of RNA was done using the Trizol kit. Real-time fluorescence quantitative PCR assay was done to obtain the relative expression. Results: Expressions of PANDA, LincRNA-p21, and PUMA in male and female patients or in squamous cell carcinoma and adenocarcinoma were not significantly different (P > 0.05). However, expression of... Read more
    J Cancer Metastasis Treat 2017;3:65-70. | doi:10.20517/2394-4722.2016.65
    Published on: 27 Mar 2017  | Viewed:834  | Downloaded:87
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  • Case Report|Open Access

    Large chest wall fibromatosis with challenging treatment plan

    Rashi Agrawal , Prekshi Choudhary , Arun Kumar Goel , Vaishali Zamre , Sandeep Agarwal , Dinesh Singh
    The primary mode of treatment for desmoid tumors is surgical excision. However, high recurrence rates (39-79%) have been reported when surgery is used alone. The role of adjuvant radiotherapy after surgical resection of primary disease is controversial and should be based on a balanced discussion of potential morbidity from radiotherapy and local recurrence. In this patient, the maximum dimension of tumor was 21 cm. This is a larger chest wall fibromatosis than has been reported thus far, to the best of our knowledge. In this case, post-operative margins were free, but in view of the large... Read more
    J Cancer Metastasis Treat 2017;3:139-43. | doi:10.20517/2394-4722.2017.02
    Published on: 21 Jul 2017  | Viewed:822  | Downloaded:78
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  • Minireview|Open Access

    Treatment of liver metastases in patients selected for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis

    Antonio Sommariva
    Cytoreductive surgery (CS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have gained increasing consensus in treatment of peritoneal carcinomatosis from colorectal cancer. The presence of liver metastases is generally considered a contraindication for CS + HIPEC, as hepatic involvement no longer represents a loco-regional aspect of disease. Despite this, liver resection (LR) has been tested in selected cases in combination with CS + HIPEC for treatment of peritoneal carcinomatosis with liver metastasis. Relevant studies on this topic were identified through a search in the... Read more
    J Cancer Metastasis Treat 2017;3:362-7. | doi:10.20517/2394-4722.2017.37
    Published on: 21 Dec 2017  | Viewed:786  | Downloaded:7
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  • Case Report|Open Access

    Uterine large cell neuroendocrine carcinoma with unusual colonic metastasis

    Antonio Ieni , Giuseppe Angelico , Rosalba De Sarro , Francesco Fleres , Antonio Macrì , Giovanni Tuccari
    A 78-year-old female patient arrived at our practice complaining of progressive abdominal increase and presenting a clinical picture of intestinal obstruction. At physical examination, the abdomen appeared distended, moderately painful with the presence of a mass of hard consistency. Abdominal computed tomography scan showed a large hypodense pelvic mass that indicated a compression and lateral deviation of the uterus and bladder. Microscopically, the mass showed a uniform solid pattern, composed of medium and large-sized cells with hyperchromatic and pleomorphic nuclei demonstrating high... Read more
    J Cancer Metastasis Treat 2017;3:144-9. | doi:10.20517/2394-4722.2017.15
    Published on: 16 Aug 2017  | Viewed:745  | Downloaded:45
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  • Case Report|Open Access

    Chest wall metastasis in squamous cell carcinoma of buccal mucosa

    Jayesh Shyamnandan Singh , Ashutosh Das Sharma
    Metastases from head and neck cancers is rare occurrence. The common form of failure/recurrence in these cancers are local site recurrence or nodal metastases. Distant metastases are very rare and are most commonly seen in the lung, brain, liver and bones, and the latent period between the development of the primary and the distant metastases is usually long. There are very few cases reported of chest wall metastases from squamous cell carcinoma of head and neck. This article reports such a case of squamous cell carcinoma of buccal mucosa metastasizing to the chest wall four months after... Read more
    J Cancer Metastasis Treat 2017;3:78-81. | doi:10.20517/2394-4722.2017.08
    Published on: 28 Apr 2017  | Viewed:723  | Downloaded:65
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  • Original Article|Open Access

    The synergy of Helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer

    Jie Liu , Han Wang , Gang Chen , Mo Yang , Zhi-Xian Wu , Russell Erick Ericksen , Alice Sze Tsai Wong , Weiping Han , Jin-Zhang Zeng
    Aim: To study the impact of Helicobacter pylori (H. pylori) and lipid metabolic disorder on the expression of Th17-related cytokines in gastric cancer (GC). Methods: GC specimens were randomly collected from 42 patients, of whom 15 had H. pylori infection and 27 were without. Tumor RNA was extracted for reverse transcription quantitative polymerase chain reaction quantification of gene expression. Results: The mRNA levels of interleukin (IL)-6 and leptin, which are known to regulate Th17 differentiation, were upregulated by 20 and 6 folds, respectively, in H. pylori-infected compared to... Read more
    J Cancer Metastasis Treat 2017;3:169-76. | doi:10.20517/2394-4722.2017.46
    Published on: 29 Aug 2017  | Viewed:718  | Downloaded:62
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    Getting better at treating prostate cancer: what clinicians should want from scientists

    Malcolm Mason
    If the treatment landscape for prostate cancer is to be transformed, clinicians and scientists must work together ever more closely. Prostate cancer defeats physicians when patients are not accurately stratified according to patients’ risk of dying of disease, when the effects of tumor heterogeneity are insufficiently understood, and when attempts at therapy by clinicians spur further disease evolution and the emergence of new resistance mechanisms. At the same time, clinicians’ over-treat men who in reality do not need it, and some of those men needlessly suffer long term side effects as a... Read more
    J Cancer Metastasis Treat 2017;3:271-7. | doi:10.20517/2394-4722.2017.51
    Published on: 17 Nov 2017  | Viewed:690  | Downloaded:29
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  • Original Article|Open Access

    Malignant field expression signatures in biopsy samples at diagnosis predict the likelihood of lethal disease in patients with localized prostate cancer

    Gennadi V. Glinsky
    Aim: Overtreatment of early-stage low-risk prostate cancer patients represents a significant problem in disease management and has significant socio-economic implications. Changes in prostate cancer screening and treatment practices in the United States have been associated with the recent decline in overall incidence and concomitant significant increase of the annual incidence of metastatic prostate cancer has been documented. Therefore, development of genetic and molecular markers of clinically significant disease in patients diagnosed with low grade localized prostate cancer would have a... Read more
    J Cancer Metastasis Treat 2017;3:177-89. | doi:10.20517/2394-4722.2017.43
    Published on: 21 Sep 2017  | Viewed:619  | Downloaded:18
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  • Original Article|Open Access

    Percutaneous, computed tomography guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients

    Periklis Zavridis , Maria Tsitskari , Argyro Mazioti , Dimitrios Filippiadis
    Aim: This study evaluates the efficacy and safety of percutaneous computed tomography (CT)-guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients. Methods: Over the course of 16 months, 22 patients underwent radiofrequency neurolysis as palliative therapy for pain reduction in celiac and splachnic plexus (n = 9), thoracic (n = 1), lumbar (n = 2) and superior hypogastric plexus (n = 5), as well as stellate ganglion (n = 5). Pain levels before treatment, one week after treatment, and at the last follow-up (average follow-up 6 months) were compared by means... Read more
    J Cancer Metastasis Treat 2017;3:60-4. | doi:10.20517/2394-4722.2017.04
    Published on: 27 Mar 2017  | Viewed:591  | Downloaded:46
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  • Case Report|Open Access

    Report of primary leiomyosarcoma of renal pelvis and literature review

    Abhidha Malik , Ritesh Kumar , Abhishek Shankar , Sunil Chumber , Sameer Bakhshi , Seema Kaushal , Bala Thirunavukkarasu
    Primary sarcomas of kidney are exceptionally rare tumors, accounting for only 1-2% of all malignant tumors of kidney. Leiomyosarcoma (LMS) is the most common histological subtype among all renal sarcomas. The authors describe here a case of primary leiomyosarcoma of renal pelvis in a 50-year-old lady, presenting with flank pain. Based on triple phase cardio-electroencephalographic covariance tracing abdomen, presumptive diagnosis of renal cell carcinoma/renal sarcoma/neurogenic tumor was made and patient underwent radical nephrectomy. Microscopy reflected spindle cell tumor which showed... Read more
    J Cancer Metastasis Treat 2017;3:111-5. | doi:10.20517/2394-4722.2017.12
    Published on: 30 Jun 2017  | Viewed:583  | Downloaded:42
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

    Agnese C. Pippione , Donatella Boschi , Klaus Pors , Simonetta Oliaro-Bosso , Marco L. Lolli
    Androgens play an important role in prostate cancer (PCa) development and progression. Although androgen deprivation therapy remains the front-line treatment for advanced prostate cancer, patients eventually relapse with the lethal form of the disease. The prostate tumor microenvironment is characterised by elevated tissue androgens that are capable of activating the androgen receptor (AR). Inhibiting the steroidogenic enzymes that play vital roles in the biosynthesis of testosterone (T) and dihydrotestosterone (DHT) seems to be an attractive strategy for PCa therapies. Emerging data... Read more
    J Cancer Metastasis Treat 2017;3:328-61. | doi:10.20517/2394-4722.2017.44
    Published on: 12 Dec 2017  | Viewed:579  | Downloaded:30
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    Getting closer to prostate cancer in patients - what scientists should want from clinicians

    Norman J. Maitland
    For scientists pursuing drug development for prostate cancer, it is critical that an appropriate ex vivo or in vitro model system is available for study. Cancer research has generally consisted of: (1) finding the means to arrest fast growing cancer cells; or (2) (as a compromise) to slow down the excessive rate of cell growth; or in the best case (3) to kill the cancer cells whilst sparing the surrounding normal tissues. As the knowledge of the biological nature of the cancer cell improves, it has become increasingly apparent that such a simplistic attitude to cancer therapy development or... Read more
    J Cancer Metastasis Treat 2017;3:262-70. | doi:10.20517/2394-4722.2017.23
    Published on: 17 Nov 2017  | Viewed:498  | Downloaded:32
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  • Topic: Cancer Immunotherapy|Open Access

    Immunological aspect of the liver and metastatic uveal melanoma

    Mizue Terai , Michael J. Mastrangleo , Takami Sato
    Uveal (eye) melanoma is the most common primary eye malignancy in adults. Despite optimal treatments for primary uveal melanoma, up to 50% of patients subsequently develop systemic metastasis, often in the liver. Once hepatic metastasis develops, the survival of patients is generally short and currently available treatments fail to show meaningful improvement of survival. Recent development of immune checkpoint blockades revolutionized immunotherapy for metastatic cutaneous (skin) melanoma. Unfortunately, metastatic uveal melanoma is unresponsive to this approach, thus there is an unmet... Read more
    J Cancer Metastasis Treat 2017;3:231-43. | doi:10.20517/2394-4722.2017.39
    Published on: 31 Oct 2017  | Viewed:470  | Downloaded:38
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  • Commentary|Open Access

    Adenosine A2B receptor: novel anti-cancer therapeutic implications

    Silvia Paola Corona , Navid Sobhani , Daniele Generali
    J Cancer Metastasis Treat 2017;3:206-8. | doi:10.20517/2394-4722.2017.50
    Published on: 27 Sep 2017  | Viewed:459  | Downloaded:37
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  • Topic: Cancer Immunotherapy|Open Access

    Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery

    Yohsuke Yagawa , Keishi Tanigawa , Yasunobu Kobayashi , Masakazu Yamamoto
    Hyperthermia is a type of medical modality for cancer treatment using the biological effect of artificially induced heat. Even though the intrinsic effects of elevated body temperature in cancer tissues are poorly understood, increasing the temperature of the body has been recognized as a popular therapeutic method for tumorous lesions as well as infectious diseases since ancient times. Recently accumulated evidence has shown that hyperthermia amplifies immune responses in the body against cancer while decreasing the immune suppression and immune escape of cancer. It also shows that... Read more
    J Cancer Metastasis Treat 2017;3:218-30. | doi:10.20517/2394-4722.2017.35
    Published on: 31 Oct 2017  | Viewed:425  | Downloaded:63
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    HOX transcription factors and the prostate tumor microenvironment

    Richard Morgan , Hardev S. Pandha
    It is now well established that the tumor microenvironment plays an essential role in the survival, growth, invasion, and spread of cancer through the regulation of angiogenesis and localized immune responses. This review examines the role of the HOX genes, which encode a family of homeodomain-containing transcription factors, in the interaction between prostate tumors and their microenvironment. Previous studies have established that HOX genes have an important function in prostate cancer cell survival in vitro and in vivo, but there is also evidence that HOX proteins regulate the... Read more
    J Cancer Metastasis Treat 2017;3:278-87. | doi:10.20517/2394-4722.2017.31
    Published on: 6 Dec 2017  | Viewed:422  | Downloaded:20
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  • Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?|Open Access

    Membrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting

    Robert A. Falconer , Paul M. Loadman
    The membrane-type matrix metalloproteinases (MT-MMPs), an important subgroup of the wider MMP family, demonstrate widespread expression in multiple tumor types, and play key roles in cancer growth, migration, invasion and metastasis. Despite a large body of published research, relatively little information exists regarding evidence for MT-MMP expression and function in metastatic prostate cancer. This review provides an appraisal of the literature describing gene and protein expression in prostate cancer cells and clinical tissue, summarises the evidence for roles in prostate cancer... Read more
    J Cancer Metastasis Treat 2017;3:315-27. | doi:10.20517/2394-4722.2017.40
    Published on: 12 Dec 2017  | Viewed:375  | Downloaded:32
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  • Original Article|Open Access

    Health-related quality of life and its correlates among rectal cancer survivors, Northwest of Iran

    Nayyereh Aminisani , Mehdi Fatemi , Parvin Sarbakhsh , Alireza Nikanfar , Amirtaher Eftekharsadat , Esmat Jafari
    Aim: The objective of this study was to examine the health-related quality of life (HRQOL), and its correlates among rectal cancer survivors in northwest of Iran. Methods: This cross-sectional study was conducted in northwest of Iran. Rectal cancer survivors were selected from teaching hospitals. HRQOL was estimated using the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30. Information about socio-demographic, lifestyle and clinical features of disease was obtained by trained interviewers. Results: A total of 96 patients were included in this... Read more
    J Cancer Metastasis Treat 2017;3:209-16. | doi:10.20517/2394-4722.2017.47
    Published on: 29 Sep 2017  | Viewed:370  | Downloaded:28
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  • Topic: Cancer Immunotherapy|Open Access

    Cell-mediated immunotherapy for hepatocellular carcinoma

    Wei-Chen Lee
    Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Most of the time, these tumors are diagnosed at late stages. Because no effective treatments exist for patients with advanced stage HCC, there is an urgent need for novel, effective treatments. Cancer cells originate as a consequence of abnormal expression of oncogenes or loss of tumor suppressor genes. Often, neoplastic transformation results in a hyper-mutated cellular genome, which in turn produces neo-antigens from mutated genes. These tumor-specific or tumor-associated antigens can be recognized by... Read more
    J Cancer Metastasis Treat 2017;3:244-9. | doi:10.20517/2394-4722.2017.48
    Published on: 31 Oct 2017  | Viewed:361  | Downloaded:31
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  • Topic: Cancer Immunotherapy|Open Access

    Introduction to the Special Issue on Cancer Immunotherapy

    Shuen-Kuei Liao
    J Cancer Metastasis Treat 2017;3:217. | doi:10.20517/2394-4722.2017.21
    Published on: 31 Oct 2017  | Viewed:244  | Downloaded:57
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  • Original Article|Open Access

    Impact of previous anti-angiogenesis treatment in nivolumab-treated advanced non-small cell lung cancer

    Takefumi Komiya , Chao H. Huang , Prakash Neupane , Stephen K. Williamson , Prabhakar Chalise
    Aim: To investigate how previous systemic therapy such as anti-angiogenesis can influence cancer immunotherapy for non-small cell lung cancer (NSCLC). Methods: A total of 134 patients with advanced NSCLC who were treated with nivolumab were retrospectively reviewed. Correlation between status of prior anti-angiogenesis treatment and clinical characteristics were determined. Impact of prior anti-angiogenesis on therapeutic outcome of nivolumab was investigated for tumor efficacy such as progression-free survival (PFS). Results: Sixteen patients were treated with at least one... Read more
    J Cancer Metastasis Treat 2018;4:1. | doi:10.20517/2394-4722.2017.65
    Published on: 17 Jan 2018  | Viewed:48  | Downloaded:2
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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