Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies
Epigenetic alterations, including DNA methylation, histone modifi cation, loss of genome imprinting, chromatin remodeling and non-coding RNAs, are associated with human carcinogenesis. Among them, DNA methylation is a fundamental epigenetic process to modulate gene expression. In cancer cells, altered DNA methylation includes hypermethylation of site-specific CpG island promoter and global DNA hypo-methylation. Detection of aberrant gene promoter methylation has been applied to the clinic to stratify risk in cancer development, detect early cancer and predict clinical outcomes....
Published on: 15 Oct 2015