Most Viewed: Last TWO YEARS
  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Targeting cerebrospinal fluid for discovery of brain cancer biomarkers

    Tarek Shalaby , Federica Achini , Michael A. Grotzer
    Central nervous system (CNS) cancer is a devastating illness with unmet therapeutic needs. Establishing biomarkers that have the potential to guide accurate CNS cancer diagnosis or are helpful in predicting disease progression or therapy response is of great interest. Cerebrospinal fluid (CSF) has been extensively targeted for the detection of molecules that might be useful markers for cancer detection. However, so far very few of such markers have found a standardized routine clinical application. This review examines the current scientific knowledge about the biochemical elements in the... Read more
    J Cancer Metastasis Treat 2016;2:176-87. | doi:10.20517/2394-4722.2016.12
    Published on: 18 May 2016  | Viewed:20536  | Downloaded:506
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Tailored nanocarriers and bioconjugates for combating glioblastoma and other brain tumors

    Fatema ELAmrawy , Amr A. Othman , Chris Adkins , Aliaa Helmy , Mohamed I. Nounou
    Worldwide, the incidence of primary brain tumors is on the rise. Unfortunately, noninvasive drug therapy is hampered by poor access of most drugs to the brain due to the insurmountable blood-brain barrier (BBB). Nanotechnology holds great promise for noninvasive therapy of severe brain diseases. Furthermore, recent bioconjugation strategies have enabled the invasion of the BBB via tailored-designed bioconjugates either with targeting moieties or alterations in the physicochemical and/or the pharmacokinetic parameters of central nervous system (CNS) active pharmaceutical ingredients.... Read more
    J Cancer Metastasis Treat 2016;2:112-22. | doi:10.20517/2394-4722.2015.78
    Published on: 11 Mar 2016  | Viewed:18939  | Downloaded:812
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  • Review|Open Access

    Function of cancer cell-derived extracellular matrix in tumor progression

    Gao-Feng Xiong , Ren Xu
    Extracellular matrix (ECM) is an essential component of the tumor microenvironment. Cancer development and progression are associated with increased ECM deposition and crosslink. The chemical and physical signals elicited from ECM are necessary for cancer cell proliferation and invasion. It is well recognized that stromal cells are a major source of ECM proteins. However, recent studies showed that cancer cells are also an active and important component in ECM remodeling. Cancer cells deposit a significant amount of collagen, fibronectin, and tenascin C (TNC). Recent studies demonstrate... Read more
    J Cancer Metastasis Treat 2016;2:357-64. | doi:10.20517/2394-4722.2016.08
    Published on: 18 Sep 2016  | Viewed:18320  | Downloaded:644
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

    Silvia Crespo , Marcus Kind , Alexandre Arcaro
    The PI3K/AKT/mTOR (PAM) pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer progression. It has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children, malignant gliomas and medulloblastomas (MB). In these tumors, the PAM network controls key functions necessary for cell invasion and metastasis, such as cell motility. This review summarizes the current knowledge about the role of PAM signaling in cell invasion and metastasis in gliomas and MB. Current approaches to... Read more
    J Cancer Metastasis Treat 2016;2:80-9. | doi:10.20517/2394-4722.2015.72
    Published on: 11 Mar 2016  | Viewed:18263  | Downloaded:671
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Dissecting brain tumor growth and metastasis in vitro and ex vivo

    Michael A. Grotzer , Anuja Neve , Martin Baumgartner
    Local infiltration and distal dissemination of tumor cells hamper efficacy of current treatments against central nervous system (CNS) tumors and greatly influence mortality and therapy-induced long-term morbidity in survivors. A number of in vitro and ex vivo assay systems have been established to better understand the infiltration and metastatic processes, to search for molecules that specifically block tumor cell infiltration and metastatic dissemination and to pre-clinically evaluate their efficaciousness. These systems allow analytical testing of tumor cell viability and motile and... Read more
    J Cancer Metastasis Treat 2016;2:149-62. | doi:10.20517/2394-4722.2016.02
    Published on: 18 May 2016  | Viewed:11747  | Downloaded:595
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Therapeutic strategies for targeting cancer stem cells