Most Viewed: Last TWO YEARS
  • Review|Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo
    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development through various mechanisms such as nuclear organization, post-transcription regulation, alternative splicing, and epigenetic regulation. Thus, aberrant expression of lncRNAs can cause abnormality in those cellular functions and lead to various pathological conditions. One of such fatal consequences is... Read more
    J Cancer Metastasis Treat 2016;2:1-10. | doi:10.4103/2394-4722.171829
    Published on: 15 Jan 2016  | Viewed:202682  | Downloaded:640
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Targeting cerebrospinal fluid for discovery of brain cancer biomarkers

    Tarek Shalaby , Federica Achini , Michael A. Grotzer
    Central nervous system (CNS) cancer is a devastating illness with unmet therapeutic needs. Establishing biomarkers that have the potential to guide accurate CNS cancer diagnosis or are helpful in predicting disease progression or therapy response is of great interest. Cerebrospinal fluid (CSF) has been extensively targeted for the detection of molecules that might be useful markers for cancer detection. However, so far very few of such markers have found a standardized routine clinical application. This review examines the current scientific knowledge about the biochemical elements in the... Read more
    J Cancer Metastasis Treat 2016;2:176-87. | doi:10.20517/2394-4722.2016.12
    Published on: 18 May 2016  | Viewed:16482  | Downloaded:472
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Tailored nanocarriers and bioconjugates for combating glioblastoma and other brain tumors

    Fatema ELAmrawy , Amr A. Othman , Chris Adkins , Aliaa Helmy , Mohamed I. Nounou
    Worldwide, the incidence of primary brain tumors is on the rise. Unfortunately, noninvasive drug therapy is hampered by poor access of most drugs to the brain due to the insurmountable blood-brain barrier (BBB). Nanotechnology holds great promise for noninvasive therapy of severe brain diseases. Furthermore, recent bioconjugation strategies have enabled the invasion of the BBB via tailored-designed bioconjugates either with targeting moieties or alterations in the physicochemical and/or the pharmacokinetic parameters of central nervous system (CNS) active pharmaceutical ingredients.... Read more
    J Cancer Metastasis Treat 2016;2:112-22. | doi:10.20517/2394-4722.2015.78
    Published on: 11 Mar 2016  | Viewed:15091  | Downloaded:753
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

    Silvia Crespo , Marcus Kind , Alexandre Arcaro
    The PI3K/AKT/mTOR (PAM) pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer progression. It has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children, malignant gliomas and medulloblastomas (MB). In these tumors, the PAM network controls key functions necessary for cell invasion and metastasis, such as cell motility. This review summarizes the current knowledge about the role of PAM signaling in cell invasion and metastasis in gliomas and MB. Current approaches to... Read more
    J Cancer Metastasis Treat 2016;2:80-9. | doi:10.20517/2394-4722.2015.72
    Published on: 11 Mar 2016  | Viewed:14801  | Downloaded:624
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  • Review|Open Access

    Function of cancer cell-derived extracellular matrix in tumor progression

    Gao-Feng Xiong , Ren Xu
    Extracellular matrix (ECM) is an essential component of the tumor microenvironment. Cancer development and progression are associated with increased ECM deposition and crosslink. The chemical and physical signals elicited from ECM are necessary for cancer cell proliferation and invasion. It is well recognized that stromal cells are a major source of ECM proteins. However, recent studies showed that cancer cells are also an active and important component in ECM remodeling. Cancer cells deposit a significant amount of collagen, fibronectin, and tenascin C (TNC). Recent studies demonstrate... Read more
    J Cancer Metastasis Treat 2016;2:357-64. | doi:10.20517/2394-4722.2016.08
    Published on: 18 Sep 2016  | Viewed:13355  | Downloaded:513
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  • Case Report|Open Access

    Hepatocellular carcinoma presenting as rapidly growing sternal mass: an unusual presentation

    Rahul S. Kulkarni , Asha S. Anand , Apurva A. Patel , Sandip A. Shah
    Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. The most frequent sites of metastases are lungs, regional lymph nodes, adrenals and bones. However, an isolated sternal metastasis from HCC as an initial presentation has been rarely reported. A 45-year-old man presented with a progressively increasing mass over the anterior chest wall. On investigations, it was found to be arising from the sternum. Histopathology was suggestive of metastatic HCC, later confirmed by the presence of a 9 cm × 7 cm mass in the liver on abdominal computed tomography scan and a... Read more
    J Cancer Metastasis Treat 2016;2:41-3. | doi:10.4103/2394-4722.169643
    Published on: 15 Jan 2016  | Viewed:9716  | Downloaded:107
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Therapeutic strategies for targeting cancer stem cells

    Yu Jeong Kim , Elizabeth L. Siegler , Natnaree Siriwon , Pin Wang
    The therapeutic limitations of conventional chemotherapeutic drugs present a challenge for cancer therapy; these shortcomings are largely attributed to the ability of cancer cells to repopulate and metastasize after initial therapies. Compelling evidence suggests that cancer stem cells (CSCs) have a crucial impact in current shortcomings of cancer therapy because they are largely responsible for tumor initiation, relapse, metastasis, and chemo-resistance. Thus, a better understanding of the properties and mechanisms underlying CSC resistance to treatments is necessary to improve patient... Read more
    J Cancer Metastasis Treat 2016;2:233-42. | doi:10.20517/2394-4722.2016.26
    Published on: 8 Jul 2016  | Viewed:9404  | Downloaded:926
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Dissecting brain tumor growth and metastasis in vitro and ex vivo

    Michael A. Grotzer , Anuja Neve , Martin Baumgartner
    Local infiltration and distal dissemination of tumor cells hamper efficacy of current treatments against central nervous system (CNS) tumors and greatly influence mortality and therapy-induced long-term morbidity in survivors. A number of in vitro and ex vivo assay systems have been established to better understand the infiltration and metastatic processes, to search for molecules that specifically block tumor cell infiltration and metastatic dissemination and to pre-clinically evaluate their efficaciousness. These systems allow analytical testing of tumor cell viability and motile and... Read more
    J Cancer Metastasis Treat 2016;2:149-62. | doi:10.20517/2394-4722.2016.02
    Published on: 18 May 2016  | Viewed:9294  | Downloaded:559
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  • Topic: Neuroendocrine Tumors|Open Access

    Review of recent advances in medical treatment for neuroendocrine neoplasms: somatostatin analogs and chemotherapy

    Francesca Spada , Monica Valente
    Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare tumours often producing high levels of hormones and causing symptoms. There are a number of different types of NENs. They usually arise as advanced and low/intermediate grade only in a minority of cases, as high grade. Treatment depends on which type and may include surgery, interventional radiology, and systemic treatment, including chemotherapy, somatostatin analogs, interferon α2b, peptide receptor radionuclide therapy, and only for pancreatic neuroendocrine tumors, molecular targeted agents, including everolimus and... Read more
    J Cancer Metastasis Treat 2016;2:313-20. | doi:10.20517/2394-4722.2016.38
    Published on: 31 Aug 2016  | Viewed:6262  | Downloaded:325
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  • Review|Open Access

    The features of peritoneal metastases from gastric cancer

    Gianni Mura , Beatrice Verdelli
    Peritoneal Carcinomatosis (PC) from metastasization of Gastric Cancer (GC), either present at first diagnosis of GC or as recurrence, is considered a fatal disease with no hope of definitive cure. Although newer agents like S1 and docetaxel have shown some promise, the median overall survival with the current first line chemotherapy is only 8 to 14 months, and is not greatly improved by adding targeted therapy. A multi-modal approach with cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) has been developed along the last two decades in order to... Read more
    J Cancer Metastasis Treat 2016;2:365-74. | doi:10.20517/2394-4722.2016.19
    Published on: 18 Sep 2016  | Viewed:6023  | Downloaded:352
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  • Review|Open Access

    Molecular and cellular aspects of extramedullary manifestations of acute myeloid leukemia

    Javad Mohammadiasl , Abbas Khosravi , Mohammad Shahjahani , Shirin Azizidoost , Najmaldin Saki
    The myeloid extramedullary tumor is a solid tumor formed by infiltration of immature myeloid cells in various tissues of the body. This tumor is also identified as chloroma or myeloid sarcoma (MS). MS is a manifestation of acute myeloid leukemia (AML) occurring at presentation or during treatment or relapse. MS is associated with multiple chromosomal abnormalities and molecular mutations since patients with these disorders bear a high potential for MS manifestation. There is a high incidence of extramedullary infiltration (EMI) in AML. AML patients with EMI have a worse prognosis than patients... Read more
    J Cancer Metastasis Treat 2016;2:44-50. | doi:10.4103/2394-4722.167230
    Published on: 29 Feb 2016  | Viewed:5704  | Downloaded:226
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  • Case Report|Open Access

    An unusual case of encapsulated papillary carcinoma of breast

    Kriti Chauhan , Monika Garg
    Intracystic (encapsulated) papillary carcinoma of breast is a rare variant of breast cancer. It is usually a low-grade tumor showing estrogen, progesterone positivity. The authors report an unusual case of intracystic papillary carcinoma showing high nuclear grade, brisk mitosis, and necrosis with triple negativity for estrogen, progesterone, and Her-2/neu receptors, as well as negative axillary lymph nodes. Such cases need to be reported to increase awareness so that they will be managed conservatively, avoiding any overtreatment despite being high grade and triple negative. Read more
    J Cancer Metastasis Treat 2016;2:224-7. | doi:10.20517/2394-4722.2015.63
    Published on: 15 Jun 2016  | Viewed:5251  | Downloaded:160
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  • Review|Open Access

    Muscarinic receptor signaling and colon cancer progression

    Guofeng Xie , Jean-Pierre Raufman
    Due to the lack of effective treatments, advanced colorectal cancer (CRC) remains a leading cause of cancer death in the United States. Emerging evidence supports the observation that muscarinic receptor (MR) signaling plays a critical role in growth and progression of CRC. MR activation by acetylcholine and bile acids results in transactivation of epidermal growth factor receptors (EGFR) and post-EGFR signal transduction that enhances cell proliferation, migration, and invasion. Here, the authors review recent progress in understanding the molecular mechanisms underlying MR-mediated CRC... Read more
    J Cancer Metastasis Treat 2016;2:195-200. | doi:10.20517/2394-4722.2016.05
    Published on: 15 Jun 2016  | Viewed:4361  | Downloaded:161
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Insights into mechanisms of tumor dissemination from circulating tumor cell lines of small cell lung cancer

    Gerhard Hamilton , Barbara Rath
    Despite the fact that the majority of cancer patients succumb to metastatic disease, most aspects of tumor metastasis are not understood in detail at present. Cell biologic steps of dissemination are difficult to characterize in human tumors and research is in large part confined to cell line and experimental animal studies. Epithelial-mesenchymal transition (EMT), intravasation of malignant cells, dissemination as circulating tumor cells (CTCs) and eventually mesenchymal-epithelial transition (MET) at distal sites are steps believed to be involved in metastasis. Small cell lung cancer... Read more
    J Cancer Metastasis Treat 2016;2:446-52. | doi:10.20517/2394-4722.2016.57
    Published on: 16 Dec 2016  | Viewed:4326  | Downloaded:150
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  • Case Report|Open Access

    Metastatic high-grade neuroendocrine tumor of mandible

    Jitender Batra , Chinmay D. Vakade , Sonal Grover , Gyanander Attresh
    Neuroendocrine tumors of the oral cavity and jaws are exceedingly rare. They include paragangliomas, a melanotic neuroectodermal tumor of infants, small cell carcinomas, and Merckel cell carcinomas. Most have been non-functional in nature. Breast, lung, liver, colon, and prostate are the most common reported primary malignancies which can metastasize to the oral cavity. In most cases, oral metastases involve maxilla and mandible rather than soft tissues. The premolar-molar region is the most common localization. The purpose of this article is to describe a rare case of a high grade... Read more
    J Cancer Metastasis Treat 2016;2:127-9. | doi:10.4103/2394-4722.170022
    Published on: 28 Mar 2016  | Viewed:4291  | Downloaded:108
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  • Review|Open Access

    Targeting Toll-like receptors against cancer

    Bing Du , Qiu-Li Jiang , Joseph Cleveland , Bing-Rong Liu , Dekai Zhang
    The discovery of Toll-like receptors (TLRs) about 20 years ago was a remarkable achievement not only in the field of immunology but also in the field of medicine. The TLRs are a family of pattern recognition receptors which play an important role in immune responses by recognizing pathogen-associated molecular patterns. The TLRs also recognize danger-associated molecular patterns, which are associated with some diseases such as cancer. Recent evidence shows that TLRs are expressed not only in immune cells but also in tumor cells. The TLRs appear to play a role in tumor progression and... Read more
    J Cancer Metastasis Treat 2016;2:463-70. | doi:10.20517/2394-4722.2016.62
    Published on: 29 Dec 2016  | Viewed:3611  | Downloaded:340
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  • Original Article|Open Access

    Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model

    Lai-Lei Ting , Andy Shau-Bin Chou , Chin-Hsuan Hsieh , Shih-Chieh Hsiung , See-Tong Pang , Shuen-Kuei Liao
    Aim: As our understanding of cancer stem cell (CSC) biology improves, search for inhibitory agents of CSCs and metastatic CSCs (mCSCs) positive for CXCR4 is warranted. Withaferin A (WA), a withanolide extracted from the medicinal plant Withania somnifera, has been shown to exhibit anti-cancer effects through multiple mechanisms. Whether WA could selectively target CSCs, mCSCs, or non-CSCs of a gastrointestinal (GI) carcinoma tumor remains unclear. Methods: Side-population (SP) analysis, flow cytometric phenotyping and sorting, non-invasive imaging in conjunction with xenotransplantation, and... Read more
    J Cancer Metastasis Treat 2016;2:29-40. | doi:10.4103/2394-4722.172008
    Published on: 15 Jan 2016  | Viewed:3307  | Downloaded:191
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Effects of Gas1 on gliomas: a review on current preclinical studies

    Jose Segovia , Elizabeth Bautista , Manuel Lara-Lozano
    Glioblastoma multiforme (GBM) is the most common and lethal brain tumor. Its prognosis remains very poor, despite the use of combined treatments such as surgical resection, radiation and chemotherapy. The major limitations for the treatment of GBM are its high invasiveness, tumor recurrence and resistance to treatments. Therefore, gene therapy appears as a relevant strategy for its treatment. Thus, we have investigated the use of growth-arrest-specific 1 (Gas1) for the treatment of GBM. Gas1 is a tumor suppressor protein that inhibits glioma growth by inducing arrest and apoptosis of tumor... Read more
    J Cancer Metastasis Treat 2016;2:101-11. | doi:10.20517/2394-4722.2015.76
    Published on: 11 Mar 2016  | Viewed:3123  | Downloaded:204
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Brain tumor surgery: supplemental intra-operative imaging techniques and future challenges

    Telmo Augusto Barba Belsuzarri , Raphael Martinelli Anson Sangenis , João Flavio Mattos Araujo
    Modern brain tumor surgery stands in the pillar of maximum safe resection. Tumor borders are always challenging, especially infiltration zones in malignant brain tumors. Novel technologies are designed for a better delineation and to increase the extent of resection (EOR) in brain tumor surgery, such as: cortical and sub-cortical mapping strategies with somatosensory-evoked potentials, awake stimulation mapping and cortical/sub-cortical stimulation for motor pathways, important for resection in eloquent areas; intra-operative imaging as functional and intra-operative magnetic resonance... Read more
    J Cancer Metastasis Treat 2016;2:70-9. | doi:10.4103/2394-4722.172249
    Published on: 11 Mar 2016  | Viewed:3036  | Downloaded:250
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  • Original Article|Open Access

    Oxidative stress and breast cancer biomarkers: the case of the cytochrome P450 2E1

    Subir Singh , Ramkumar Rajendran , Kengo Kuroda , Emiko Isogai , Marija Krstic-Demonacos , Constantinos Demonacos
    Aim: The aim of the study is to investigate the impact of the cytochrome P450 2E1, which is the most efficient CYP450 family member in generating reactive oxygen species (ROS), on cellular energy metabolism of breast cancer cells and therefore the effects of CYP2E1 on breast carcinogenesis. Methods: The estrogen receptor positive MCF-7 and the triple negative MDA-MB-231 breast cancer cells were used as experimental system to estimate ROS generation in these cells overexpressing CYP2E1 and treated with the glycolytic inhibitors 3-bromopyruvate or 2-deoxyglucose in the presence or absence of... Read more
    J Cancer Metastasis Treat 2016;2:268-76. | doi:10.20517/2394-4722.2016.42
    Published on: 29 Jul 2016  | Viewed:2949  | Downloaded:292
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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