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  • Review

    Targeting Toll-like receptors against cancer

    Bing Du , Qiu-Li Jiang , Joseph Cleveland , Bing-Rong Liu , Dekai Zhang
    The discovery of Toll-like receptors (TLRs) about 20 years ago was a remarkable achievement not only in the field of immunology but also in the field of medicine. The TLRs are a family of pattern recognition receptors which play an important role in immune responses by recognizing pathogen-associated molecular patterns. The TLRs also recognize danger-associated molecular patterns, which are associated with some diseases such as cancer. Recent evidence shows that TLRs are expressed not only in immune cells but also in tumor cells. The TLRs appear to play a role in tumor progression and...
    Published on: 29 Dec 2016
    Views: 1080
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications

    Profiling of circulating tumor cells in liquid biopsies from metastatic cancer patients

    Pravin D. Potdar , Keerti Sen
    Aim: Circulating tumor cells (CTCs) are crucial to tumor metastasis and valuable for prediction of clinical outcome in patients with solid tumors. Here, the authors aimed to establish a method for enumeration and characterization of CTCs from liquid biopsies. Methods: Peripheral blood mononuclear cells (PBMCs) were separated from blood samples from patients with metastatic cancer using Ficoll-Hypaque gradients and cultured to isolate and enumerate CTCs. Cultured CTCs were morphologically characterized by light and phase contrast microscopy. The tumorigenicity of Ficoll-Hypaque-separated...
    Published on: 23 Jan 2017
    Views: 483
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  • Original Article

    ERCC1 expression in patients with colorectal cancer: a pilot study

    Kinjal K. Gajjar , Deep Kumari Yadav , Toral P. Kobawala , Trupti I. Trivedi , Hemangini H. Vora , Nandita R. Ghosh
    Aim: Excision repair cross complementation group 1 (ERCC1) has a key role in enhanced DNA damage repair caused by oxaliplatin-based therapy and may lead to resistance of these platinum drugs in colorectal cancer (CRC) patients. Hence, the present preliminary study aimed to explore the role of ERCC1 C/T polymorphism at codon 118 as well as its immunoreactivity in patients with primary CRC. Methods: ERCC1 polymorphism was studied using PCR-RFLP and ERCC1 protein expression was examined by immunohistochemistry in 50 CRC patients. Results: ERCC1 codon 118 C/T polymorphism analysis reported the...
    Published on: 29 Dec 2016
    Views: 433
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications

    A versatile method for enumeration and characterization of circulating tumor cells from patients with breast cancer

    Ujjwala M. Warawdekar , Vani Parmar , Aruna Prabhu , Abhay Kulkarni , Meenal Chaudhari , Rajendra A. Badwe
    Aim: To establish a standardized protocol for the isolation and enumeration of circulating tumor cells (CTCs) from peripheral blood of patients with metastatic breast cancer. Methods: The protocol used tumor cells spiked in a lymphoid cell line with detection by flow cytometry and quantitative reverse transcription polymerase chain reaction (QRT-PCR). Cells of the human mammary cancer subtypes were spiked into Jurkat cells, which served as the lymphocyte designate in numbers from 10 to 500 per 105 Jurkat cells. This mixed population was probed for CD45, EpCAM, and pancytokeratin acquired...
    Published on: 23 Feb 2017
    Views: 382
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications

    Lung cancer biopsy dislodges tumor cells into circulating blood

    Noriyoshi Sawabata , Tomotaka Kitamura , Yuko Nitta , Tomoyo Taketa , Takeshi Ohno , Tatsuya Fukumori , Takeru Hyakutake , Takahito Nakamura
    Aim: A “seed” of lung cancer metastasis is circulating tumor cells (CTCs), which may be dislodged from a tumor during biopsy. This possibility was assessed among patients who underwent lung tumor biopsy using flexible fiber-topic bronchoscopy (FFB). Methods: The study involved six patients with non-small cell lung cancer who underwent FFB biopsy to diagnose a lesion pathologically (5 males and 1 female, median age 63 years, six adenocarcinomas, of four clinical-stage IA, one stage IB, and one stage IIIA), CTCs were extracted from the peripheral vein blood at pre-FFB and at post-FFB using a...
    Published on: 23 Jan 2017
    Views: 343
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications

    Circulating tumor cells: hope to diagnose and treat metastatic cancer

    Pravin D. Potdar
    Published on: 12 Jan 2017
    Views: 337
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  • Review

    Cytogenetic and molecular basis of BCR-ABL myelodysplastic syndrome: diagnosis and prognostic approach

    Mostafa Paridar , Omid Kiani Ghalesardi , Mohammad Seghatoleslami , Ahmad Ahmadzadeh , Abbas Khosravi , Najmaldin Saki
    Myelodysplastic syndromes (MDS) include a heterogeneous group of blood disorders generally afflicting older people. Several genetic factors have been reported from these patients that have an important role in the diagnosis, prognosis, and treatment of this disease. BCR-ABL1 is a genetic factor that has occasionally been reported in some studies. This review attempts to characterize MDS patients reported to harbor this fusion and to assess the diagnostic, therapeutic, and prognostic potential of BCR-ABL1 fusionin MDS patients. This review showed that BCR-ABL fusion has been reported in 22...
    Published on: 28 Feb 2017
    Views: 262
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  • Letter to Editor

    Use of a dedicated day care unit in a modern radiation oncology facility -- a short audit

    Tejinder Kataria , Susovan Banerjee , Nimesh Dahima , Deepak Gupta , Trinanjan Basu , Shikha Goyal
    Published on: 23 Jan 2017
    Views: 259
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  • Case Report

    Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib

    Hiroto Kaneko , Kazuho Shimura , Yosuke Matsumoto , Mihoko Yoshida , Masafumi Taniwaki , Junya Kuroda
    Alkaline phosphatase (ALP) flare has been reported to occur during cancer treatment as a favorable event, particularly in the presence of bone metastasis. There have been only a few reports in lung cancer and associated radiographic findings have seldom been described. The authors observed ALP flare in a female patient with lung adenocarcinoma soon after the initiation of gefitinib. Moreover, on computed tomography, metastatic lesions of the rib and thoracic spine showed marked hyperostosis, with sizes larger than the original bone structure, suggesting efficacy of gefitinib. The...
    Published on: 23 Feb 2017
    Views: 143
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