Articles
  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Epithelial-mesenchymal transition in gastroenterological cancer

    Hirohisa Okabe , Kosuke Mima , Seiya Saito , Hiromitsu Hayashi , Katsunori Imai , Hidetoshi Nitta , Daisuke Hashimoto , Akira Chikamoto , Takatoshi Ishiko , Toru Beppu , Hideo Baba
    Epithelial-mesenchymal transition (EMT) was first reported as an essential process in embryonic cells and later showed that cancer cells, regardless of the context, exhibited a similar phenomenon that was crucial for tumor progression. Epithelial cells lose their adhesive characteristic capacity... Read more
    J Cancer Metastasis Treat 2015;1:183-9. | doi:10.4103/2394-4722.165118
    Published on: 15 Oct 2015  | Viewed:2551  | Downloaded:168
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Cancer metabolism in gastrointestinal cancer

    Hiroshi Sawayama , Nobutomo Miyanari , Hideo Baba
    Cancer cells exhibit altered glucose metabolism, mitochondrial dysfunction, anaerobic glycolysis and upregulation of the pentose phosphate pathway (PPP). Recent genetic and metabolic analyses have provided insights into the molecular mechanisms of genes that are involved in the alteration of... Read more
    J Cancer Metastasis Treat 2015;1:172-82. | doi:10.4103/2394-4722.165533
    Published on: 15 Oct 2015  | Viewed:3215  | Downloaded:183
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Trends in clinical use of targeted therapy for gastrointestinal cancers

    Kojiro Eto , Masayuki Watanabe
    Targeted drugs therapies that block the molecular pathways involved in the development and progression of gastro-intestinal (GI) cancers have recently gained considerable attention. In addition to agents targeting vascular endothelial growth factor (VEGF), epidermal growth factor receptor, the... Read more
    J Cancer Metastasis Treat 2015;1:163-71. | doi:10.4103/2394-4722.166997
    Published on: 15 Oct 2015  | Viewed:3296  | Downloaded:133
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Molecular insights into colorectal cancer stem cell regulation by environmental factors

    Daisuke Izumi , Takatsugu Ishimoto , Yasuo Sakamoto , Yuji Miyamoto , Hideo Baba
    Colorectal cancer remains a significant cause of cancer-related mortality worldwide, mainly because of tumor relapse and metastases. Cancer stem cells (CSCs) are considered to be the main cause of resistance to chemotherapeutic agents, as well as being responsible for distant metastases. Although... Read more
    J Cancer Metastasis Treat 2015;1:156-62. | doi:10.4103/2394-4722.165532
    Published on: 15 Oct 2015  | Viewed:4235  | Downloaded:217
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    MicroRNAs in gastrointestinal cancer: a novel biomarker and its clinical application

    Yukiharu Hiyoshi , Masayuki Watanabe
    Gastrointestinal (GI) cancers remain one of the most common malignancies and are the major cause of cancer deaths worldwide. Significant advancements have improved our understanding of the pathogenesis and pathology of GI cancers, but high mortality rates, an unfavorable prognosis, and lack of... Read more
    J Cancer Metastasis Treat 2015;1:144-55. | doi:10.4103/2394-4722.161617
    Published on: 15 Oct 2015  | Viewed:2768  | Downloaded:155
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Chronic inflammation and gastrointestinal cancer

    Satoshi Ida , Masayuki Watanabe , Hideo Baba
    Chronic inflammation has been identified as an important risk factor in the development of the gastrointestinal (GI) tract cancers, and the underlying molecular mechanisms have been studied extensively. Chronic inflammation is able to trigger cellular events to promote malignant transformation of... Read more
    J Cancer Metastasis Treat 2015;1:138-43. | doi:10.4103/2394-4722.166994
    Published on: 15 Oct 2015  | Viewed:4107  | Downloaded:224
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    The clinical significance of circulating tumor cells in gastrointestinal cancer

    Masaaki Iwatsuki , Junji Kurashige , Takatsugu Ishimoto , Keisuke Kosumi , Yoshifumi Baba , Yasuo Sakamoto , Yuji Miyamoto , Naoya Yoshida , Masayuki Watanabe , Hideo Baba
    Circulating tumor cells (CTCs) are originated from the primary tumor lesion into the blood stream. CTCs could lead to recurrence of gastrointestinal (GI) cancers, even after a curative resection and colonizing in the distant organs to facilitate tumor distant metastasis; however, it has been... Read more
    J Cancer Metastasis Treat 2015;1:130-7. | doi:10.4103/2394-4722.165534
    Published on: 15 Oct 2015  | Viewed:3554  | Downloaded:242
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Overview of genetic and epigenetic alterations in the pathogenesis of esophagogastric junctional adenocarcinoma and esophageal adenocarcinoma: recent findings by next generation sequencing

    Yu Imamura , Ryuma Tokunaga , Kenichi Nakamura , Hideo Baba , Masayuki Watanabe
    Esophagogastric junctional adenocarcinoma is commonly treated as esophageal adenocarcinoma (EAC) and has dramatically increased in Western countries for several decades. The similar trend has been observed in Asian countries (not in China). Barrett’s esophagus (BE) is a widely accepted precursor... Read more
    J Cancer Metastasis Treat 2015;1:123-9. | doi:10.4103/2394-4722.161620
    Published on: 15 Oct 2015  | Viewed:2415  | Downloaded:150
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Epigenetic changes in gastrointestinal cancers

    Hironobu Shigaki , Yoshifumi Baba , Kazuto Harada , Naoya Yoshida , Masayuki Watanabe , Hideo Baba
    Epigenetic alterations, including DNA methylation, histone modifi cation, loss of genome imprinting, chromatin remodeling and non-coding RNAs, are associated with human carcinogenesis. Among them, DNA methylation is a fundamental epigenetic process to modulate gene expression. In cancer cells,... Read more
    J Cancer Metastasis Treat 2015;1:113-22. | doi:10.4103/2394-4722.166991
    Published on: 15 Oct 2015  | Viewed:4967  | Downloaded:184
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Introduction to Volume 1 Issue 3 of Journal of Cancer Metastasis and Treatment

    Masayuki Watanabe
    J Cancer Metastasis Treat 2015;1:111-2. | doi:10.4103/2394-4722.166973
    Published on: 15 Oct 2015  | Viewed:2385  | Downloaded:94
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  • Review|Open Access

    Growth factor receptors: promising drug targets in cancer

    Snigdha Tiash , Ezharul Hoque Chowdhury
    Genetic, epigenetic and somatic changes deregulate the expression of growth factor receptors (GFRs), leading to cancer initiation and progression. Tumor cell growth and survival are orchestrated by clonal expansion and evasion of apoptotic signals in cancer cells. The growth of cells is further... Read more
    J Cancer Metastasis Treat 2015;1:190-200. | doi:10.4103/2394-4722.163151
    Published on: 15 Oct 2015  | Viewed:5408  | Downloaded:282
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  • Original Article|Open Access

    Ten years of lung cancer in a single center: gender, histology, stage and survival

    Regina Gironés , Pedro López , Rebeca Chulvi , Mamen Cañabate , Torregrosa M. Dolores
    Aim: The aim was to describe, in a prospective manner, the clinical, histopathological and epidemiological characteristics of lung cancer patients who attended as outpatients at the Lluís Alcanyís, Xàtiva Medical Oncology Hospital, València, Spain from January 2004 to July 2014. We also analyzed... Read more
    J Cancer Metastasis Treat 2015;1:201-7. | doi:10.4103/2394-4722.166971
    Published on: 15 Oct 2015  | Viewed:2363  | Downloaded:109
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  • Case Report|Open Access

    Is pregnancy wise after 12-year chemotherapy of chronic myeloid leukemia woman?

    Umesh Das , Gurulingaiah Venkata Giri , Kuntejowdahalli Lakshmaiah , Suresh Tagarapura , Lokanatha Dasappa , Govind Babu , Linu Abraham Jacob , Suresh Babu
    Diagnosis of leukemia during pregnancy is a dramatic event that poses challenges to the pregnant woman, the family, and physicians. Chronic myeloid leukemia (CML) comprises up to 10% of pregnancy-associated leukemia. There is no specific guideline for CML management in pregnant women. This study... Read more
    J Cancer Metastasis Treat 2015;1:208-10. | doi:10.4103/2394-4722.158433
    Published on: 15 Oct 2015  | Viewed:1724  | Downloaded:179
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  • Original Article|Open Access

    Withania somnifera extract reduces the invasiveness of MDA-MB-231 breast cancer and inhibits cytokines associated with metastasis

    Kamel F. Khazal , Donald L. Hill
    Aim: The aim was to examine the anti-proliferative effect of a Withania somnifera (WS) root extract in cell cultures and nude mouse xenografts of breast cancer cell line MDA-MB-231. Methods: WS root extract was used to treat tumor cells at concentrations up to 100 μg and for nude mouse... Read more
    J Cancer Metastasis Treat 2015;1:94-100. | doi:10.4103/2394-4722.157601
    Published on: 15 Jul 2015  | Viewed:6792  | Downloaded:168
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  • Original Article|Open Access

    Squamous cell carcinoma of the lung: clinical criteria for treatment strategy

    Agnese Savini , Rossana Berardi , Paola Mazzanti , Miriam Caramanti , Matteo Santoni , Mariagrazia De Lisa , Francesca Morgese , Silvia Rinaldi , Mariangela Torniai , Ilaria Fiordoliva , Azzurra Onofri , Stefano Cascinu
    Aim: Primary lung cancer is the leading cause of human cancer deaths worldwide, and squamous cell carcinoma (SCC) is one of the most frequent histologic subtypes. The aim of our study was to analyze clinical factors potentially affecting the overall outcome of advanced lung SCC patients. Methods:... Read more
    J Cancer Metastasis Treat 2015;1:90-3. | doi:10.4103/2394-4722.157974
    Published on: 15 Jul 2015  | Viewed:5336  | Downloaded:126
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  • Original Article|Open Access

    Prognostic significance of transcription factors FOXA1 and GATA-3 in ductal carcinoma in situ in terms of recurrence and estrogen receptor status

    Mamatha Chivukula , Jennifer Picarsic , Gautam Bulusu , Adam Brufsky , Gretchen Ahrendt , Gloria Carter
    Aim: The aim was to analyze the expression of novel biological transcription markers, forkhead-box A1 (FOXA1), GATA binding protein 3 (GATA-3), and established markers such as Ki-67 (MIB-1) and human epidermal growth factor receptor 2 (HER2) in estrogen receptor (ER(+)) and ER(-) ductal carcinoma... Read more
    J Cancer Metastasis Treat 2015;1:84-9. | doi:10.4103/2394-4722.157600
    Published on: 15 Jul 2015  | Viewed:5328  | Downloaded:103
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  • Case Report|Open Access

    Spinal intradural mature teratoma in an elderly patient

    Atef Ben Nsir , Karim Ben Hammouda , Imed Ben Said , Alia Zhani Kassar , Nidhameddine Kchir , Hafedh Jemel
    Spinal intradural mature teratomas are rarely encountered in adults. In this report, one of the oldest patients ever reported to harbor an intradural mature teratoma of the conus medullaris is presented, and the relevant literature concerning the teratoma’s origin, clinical presentation,... Read more
    J Cancer Metastasis Treat 2015;1:106-10. | doi:10.4103/2394-4722.157808
    Published on: 15 Jul 2015  | Viewed:4673  | Downloaded:118
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  • Review|Open Access

    Urothelial bladder cancer progression: lessons learned from the bench

    Julieta P. Afonso , Rui Freitas , Francisco Lobo , António Morais , Jorge Oliveira , Teresina Amaro , Rui M. Reis , Fátima M. Baltazar , Adhemar Longatto-Filho , Lúcio L. Santos
    Urothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refi nement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads... Read more
    J Cancer Metastasis Treat 2015;1:57-66. | doi:10.4103/2394-4722.157377
    Published on: 15 Jul 2015  | Viewed:6635  | Downloaded:167
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  • Original Article|Open Access

    Non-anthracycline chemotherapy associated with a poor outcome in elderly Egyptian patients with diffuse large B-cell non-Hodgkin lymphoma

    Ahmed A. Zeeneldin , Yasser A. Sallam , Ayman A. Gaber , Amgad A. Shaheen
    Aim: Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is the standard treatment for patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCNHL). Nevertheless, anthracyclines are contraindicated for some patients, e.g. cardiac dysfunction, severe hepatic... Read more
    J Cancer Metastasis Treat 2015;1:76-83. | doi:10.4103/2394-4722.156767
    Published on: 15 Jul 2015  | Viewed:4921  | Downloaded:118
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  • Case Report|Open Access

    Orbital metastasis from anorectal carcinoma

    Pavan Kumar Lachi , Megha S. Uppin , Monica Irukulla , Kotiyala V. Jaganadha Rao Naidu
    Pulmonary and liver metastases are common sites of distant metastasis from the rectal carcinoma. Metastases to the head and neck region are uncommon from carcinoma of the rectum, and orbital metastases are extremely rare. Here, we describe a 27-year-old female, who was diagnosed as a case of... Read more
    J Cancer Metastasis Treat 2015;1:104-5. | doi:10.4103/2394-4722.158434
    Published on: 15 Jul 2015  | Viewed:3843  | Downloaded:96
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  • Editorial|Open Access

    Introduction to Volume 1 Issue 2 of Journal of Cancer Metastasis and Treatment

    Lucio Miele
    J Cancer Metastasis Treat 2015;1:43. | doi:10.4103/2394-4722.160150
    Published on: 15 Jul 2015  | Viewed:2036  | Downloaded:87
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  • Review|Open Access

    Role of circulating tumor cells in future diagnosis and therapy of cancer

    Pravin D. Potdar , Navjeet Kaur Lotey
    Circulating tumor cells (CTCs) have become a blistering topic of discussion for oncologists because of their tremendous potential in the diagnosis and treatment of cancer. Over the past few years, they have been doled with quite an amount of research in this area understanding that CTCs are shed... Read more
    J Cancer Metastasis Treat 2015;1:44-56. | doi:10.4103/2394-4722.158803
    Published on: 15 Jul 2015  | Viewed:19971  | Downloaded:941
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  • Original Article|Open Access

    Detection and quantification of extracellular microRNAs in medulloblastoma

    Tarek Shalaby , Giulio Fiaschetti , Sylvain Baulande , Nicolas U. Gerber , Martin Baumgartner , Michael A. Grotzer
    Aim: Medu lloblastoma (MB) is the most common malignant brain tumor in children. The crucial role of extracellular-microRNAs (ex-miRNAs) in cancer has been widely recognized; however, their role in MB remains unknown. This study aimed to investigate MB-driven ex-miRNAs. Methods: Microarray... Read more
    J Cancer Metastasis Treat 2015;1:67-75. | doi:10.4103/2394-4722.157068
    Published on: 15 Jul 2015  | Viewed:4094  | Downloaded:110
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  • Case Report|Open Access

    Metastatic inguinal lymph nodes with two different histological types in a case of carcinoma of unknown primary site

    Mukur Dipi Ray , Shivam Vatsal , Sunil Kumar
    Cancer of unknown primary site is a group of uncommon cancers where patients present with metastatic disease and the primary site is not identified, even after a complete workup to establish the diagnosis. Inguinal metastasis with unknown primary is even more uncommon, and histological type is... Read more
    J Cancer Metastasis Treat 2015;1:101-3. | doi:10.4103/2394-4722.157178
    Published on: 15 Jul 2015  | Viewed:11944  | Downloaded:444
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  • Case Report|Open Access

    Metachronous metastasis of renal cell carcinoma to bilateral testis

    Sameer Nain , Suman Kharkwal , Onkar Kaur
    Unusual site metastasis as a presenting complaint of renal cell carcinoma (RCC) has been reported previously in the literature. RCC is a tumor with notoriously unpredictable behavior. The authors report an unusual case of metachronous bilateral testicular metastasis in a patient who operated for... Read more
    J Cancer Metastasis Treat 2015;1:39-40. | doi:10.4103/2394-4722.153913
    Published on: 15 Apr 2015  | Viewed:1365  | Downloaded:73
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  • Original Article|Open Access

    Incidence of bone metastasis in squamous cell carcinoma of the buccal mucosa

    Virendra Bhandari
    Aim: This retrospective study was performed to show the incidence of bone metastasis from carcinoma of the buccal mucosa. Head and neck cancer is a leading health problem in India due to an increased incidence of tobacco use and poor oral hygiene. Squamous cell carcinoma of the buccal mucosa is... Read more
    J Cancer Metastasis Treat 2015;1:27-30. | doi:10.4103/2394-4722.153444
    Published on: 15 Apr 2015  | Viewed:6828  | Downloaded:385
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  • Case Report|Open Access

    Complete response with fotemustine and bevacizumab after early progression following radiotherapy and temozolomide treatment in patient with glioblastoma multiforme

    Ovidio Fernández Calvo , María Eva Pérez López , Jesús García Gómez
    Glioblastoma multiforme is the most common type of primary central nervous system tumor and is noted for its short survival and poor response to chemotherapeutic agents. Unfortunately, the relapse rate is very high, and there is no reference drug for second-line treatment. In this study, a... Read more
    J Cancer Metastasis Treat 2015;1:36-8. | doi:10.4103/2394-4722.153446
    Published on: 15 Apr 2015  | Viewed:2098  | Downloaded:110
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  • Review|Open Access

    Patient-derived xenograft models for oncology drug discovery

    Gang Li
    The success of targeted therapies for cancer patients rests on three major components: the right target(s), the right drug and drug combination, and the right patient population. Although much progress has been made in understanding the mechanism of disease and in refi ning pharmaceutical... Read more
    J Cancer Metastasis Treat 2015;1:8-15. | doi:10.4103/2394-4722.152769
    Published on: 15 Apr 2015  | Viewed:4021  | Downloaded:520
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  • Original Article|Open Access

    Changes in human epidermal growth factor receptor 2 status between primary breast/gastric carcinomas and synchronous metastatic lymph nodes: how can we explain them?

    Antonio Ieni , Valeria Barresi , Giovanni Branca , Luana Licata , Rosario Alberto Caruso , Giovanni Tuccari
    Aim: Previous studies demonstrated discordant expression of human epidermal growth-factor receptor 2 ( HER2) between primary cancer and their recurrence/metastasis. This study further evaluated HER2 status between primary gastric and breast invasive carcinomas and paired metastatic disease to... Read more
    J Cancer Metastasis Treat 2015;1:21-6. | doi:10.4103/2394-4722.153445
    Published on: 15 Apr 2015  | Viewed:2923  | Downloaded:125
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  • Case Report|Open Access

    Malignant ascites with omental metastasis: a rare event in prostate cancer

    Rajeev Saini , Chandragouda Dodagoudar , Vineet Talwar , Sajjan Singh
    Prostate cancer is the most common type of male malignancy in the world and approximately 10-20% of prostate cancer shows a metastatic disease at initial diagnosis commonly to the bones, vertebrae, ribs, long bones, and skull. However, prostate cancer metastasis to the omentum with malignant... Read more
    J Cancer Metastasis Treat 2015;1:34-5. | doi:10.4103/2394-4722.152767
    Published on: 15 Apr 2015  | Viewed:3307  | Downloaded:229
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  • Review|Open Access

    Risk factors and molecular mechanisms of esophageal cancer: differences between the histologic subtypes

    Masayuki Watanabe
    The two major histologic subtypes of esophageal cancer have different risk factors as well as different molecular mechanisms. In this review, the differences in risk factors and genetic/epigenetic alterations between esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)... Read more
    J Cancer Metastasis Treat 2015;1:1-7. | doi:10.4103/2394-4722.153534
    Published on: 15 Apr 2015  | Viewed:11984  | Downloaded:295
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  • Original Article|Open Access

    Association between the cytotoxic T-lymphocyte antigen-4 polymorphisms and breast cancer risk and prognosis

    Meraj Farbod , Seyed Mostafa Shiryazdi , Hamid Harazi , Tahereh Nazari , Mohammad Hasan Sheikhha
    Aim: The aim was to evaluate the potential influences of cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphisms on breast cancer risk, the distribution of CTLA-4 single nucleotide polymorphisms (1661AG) in breast cancer patients and control subjects was investigated. Methods: In this... Read more
    J Cancer Metastasis Treat 2015;1:16-20. | doi:10.4103/2394-4722.153314
    Published on: 15 Apr 2015  | Viewed:4147  | Downloaded:114
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  • Case Report|Open Access

    Early stage squamous cell carcinoma of the tonsil presenting with multiple organ metastases including skin and brain after successful local treatment

    Susovan Banerjee , Dipankar Kundu , Mukti Mukherjee , Pradip Kumar Maiti
    Early stage carcinoma of the tonsil is curable, and the incidence of systemic metastasis is very low and central nervous system involvement is very rare. A patient diagnosed with early stage tonsillar carcinoma treated with chemoradiation was followed by brachytherapy boost. One and half years... Read more
    J Cancer Metastasis Treat 2015;1:31-3. | doi:10.4103/2394-4722.152761
    Published on: 15 Apr 2015  | Viewed:4548  | Downloaded:464
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  • Letter to Editor|Open Access

    Cancer preventing spices

    Ishtiaque Alam , Hashmat Imam , Zarnigar Riaz
    J Cancer Metastasis Treat 2015;1:41-2. | doi:10.4103/2394-4722.154131
    Published on: 15 Apr 2015  | Viewed:1280  | Downloaded:105
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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