Articles
  • Review|Open Access

    Targeting Toll-like receptors against cancer

    Bing Du , Qiu-Li Jiang , Joseph Cleveland , Bing-Rong Liu , Dekai Zhang
    The discovery of Toll-like receptors (TLRs) about 20 years ago was a remarkable achievement not only in the field of immunology but also in the field of medicine. The TLRs are a family of pattern recognition receptors which play an important role in immune responses by recognizing... Read more
    J Cancer Metastasis Treat 2016;2:463-70. | doi:10.20517/2394-4722.2016.62
    Published on: 29 Dec 2016  | Viewed:3611  | Downloaded:340
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  • Original Article|Open Access

    ERCC1 expression in patients with colorectal cancer: a pilot study

    Kinjal K. Gajjar , Deep Kumari Yadav , Toral P. Kobawala , Trupti I. Trivedi , Hemangini H. Vora , Nandita R. Ghosh
    Aim: Excision repair cross complementation group 1 (ERCC1) has a key role in enhanced DNA damage repair caused by oxaliplatin-based therapy and may lead to resistance of these platinum drugs in colorectal cancer (CRC) patients. Hence, the present preliminary study aimed to explore the role of... Read more
    J Cancer Metastasis Treat 2016;2:471-6. | doi:10.20517/2394-4722.2016.52
    Published on: 29 Dec 2016  | Viewed:912  | Downloaded:121
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    The significance and clinical utility of the detection of primary malignant circulating prostate cells: a review of the evidence

    Nigel P. Murray
    Primary malignant circulating prostate cells (CPCs) are those detected in blood before definitive treatment for prostate cancer. CPCs can be detected in men with benign prostate disease; however, some methods to distinguish between benign and malignant prostate cells have to be validated. This... Read more
    J Cancer Metastasis Treat 2016;2:453-62. | doi:10.20517/2394-4722.2016.55
    Published on: 16 Dec 2016  | Viewed:696  | Downloaded:92
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Insights into mechanisms of tumor dissemination from circulating tumor cell lines of small cell lung cancer

    Gerhard Hamilton , Barbara Rath
    Despite the fact that the majority of cancer patients succumb to metastatic disease, most aspects of tumor metastasis are not understood in detail at present. Cell biologic steps of dissemination are difficult to characterize in human tumors and research is in large part confined to cell line and... Read more
    J Cancer Metastasis Treat 2016;2:446-52. | doi:10.20517/2394-4722.2016.57
    Published on: 16 Dec 2016  | Viewed:4326  | Downloaded:150
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  • Original Article|Open Access

    Nibrin expression in oral squamous cell carcinoma: association with clinicopathological parameters

    Jigna H. Dave , Hemangini H. Vora , Trupti I. Trivedi , Nandita R. Ghosh
    Aim: The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma (OSCC) and its potential relationship with clinicopathological parameters. Methods: Nibrin expression was evaluated immunohistochemically using the modified H-score method.... Read more
    J Cancer Metastasis Treat 2016;2:436-42. | doi:10.20517/2394-4722.2015.82
    Published on: 25 Nov 2016  | Viewed:707  | Downloaded:100
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  • Case Report|Open Access

    Squamous cell carcinoma of tongue 18 years after renal transplantation: a case report

    Jyoti Poddar , Ashutosh Das Sharma , Ubrangala Suryanarayana Kunikullaya
    Solid organ transplant recipients are at increased risk of developing malignancies, even decades after transplant, due to the prolonged use of immunosuppressant drugs. A 35-year-old male underwent renal transplant for end stage renal disease 18 years previously and was on immunosuppressive drugs... Read more
    J Cancer Metastasis Treat 2016;2:443-5. | doi:10.20517/2394-4722.2016.36
    Published on: 25 Nov 2016  | Viewed:716  | Downloaded:92
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  • Meeting Abstracts|Open Access

    Obergurgl Research Conference Abstracts on "Cancer Stem Cells: Impact on Treatment"

    Ira-Ida Skvortsova
    J Cancer Metastasis Treat 2016;2:417-35. | doi:10.20517/2394-4722.2016.58
    Published on: 16 Nov 2016  | Viewed:767  | Downloaded:117
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  • Review|Open Access

    Nanocarrier drugs in the treatment of brain tumors

    Tereza Cerna , Marie Stiborova , Vojtech Adam , Rene Kizek , Tomas Eckschlager
    Nanoparticle-mediated targeted delivery of drugs might significantly reduce the dosage and optimize their release properties, increase specificity and bioavailability, improve shelf life, and reduce toxicity. Some nanodrugs are able to overcome the blood-brain barrier that is an obstacle to... Read more
    J Cancer Metastasis Treat 2016;2:407-16. | doi:10.20517/2394-4722.2015.95
    Published on: 31 Oct 2016  | Viewed:2713  | Downloaded:295
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  • Original Article|Open Access

    Sunitinib effectiveness and safety as first line treatment in metastatic renal cell carcinoma, in the Costa Rican population

    Esteban Gonzalez , Silvia Alfaro , Allan Ramos-Esquivel , Denis Ulises Landaverde
    Aim: Tyrosine kinase inhibitors are part of the armamentarium to treat metastatic renal cell carcinomas (mRCC). Costa Rica has approved sunitinib in the first line setting. The authors conducted a retrospective study to address the effectiveness and safety profile of sunitinib in our population... Read more
    J Cancer Metastasis Treat 2016;2:396-401. | doi:10.20517/2394-4722.2016.27
    Published on: 21 Oct 2016  | Viewed:1807  | Downloaded:168
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  • Case Report|Open Access

    Metastatic clostridial myonecrosis secondary to perforated metastatic bowel cancer

    Nasser Mohammed Amer , John Karayanis
    Spontaneous metastatic clostridial myonecrosis is a rare condition caused by Clostridium septicum. The underlying lesion is usually either a colonic neoplasm or leukemia. The authors reported a 67-year-old female who presented with acute abdomen secondary to a perforated sigmoid cancer and who... Read more
    J Cancer Metastasis Treat 2016;2:402-6. | doi:10.20517/2394-4722.2016.16
    Published on: 21 Oct 2016  | Viewed:1125  | Downloaded:84
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  • Case Report|Open Access

    Isolated breast metastasis mimicking as second primary cancer - a case report

    Manjari Shah , Umang Mithal , Sandeep Agarwal , Sweety Gupta , Disha Tiwari , Shashank Srinivasan , Asheesh Jain , Ritu Chandra
    Primary carcinoma of breast is common but breast is a rare site of metastasis and metastases from extramammary sites are even rarer. Metastasis to breast from rectal carcinoma is very unusual and till now 19 cases of breast secondaries from colorectal carcinoma have been reported in literature... Read more
    J Cancer Metastasis Treat 2016;2:391-5. | doi:10.20517/2394-4722.2016.22
    Published on: 30 Sep 2016  | Viewed:982  | Downloaded:96
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  • Case Report|Open Access

    A small solitary fibrous tumor of the bladder

    Guido Petracco , Carlo Patriarca
    The authors present a case of histologically benign and incidentally discovered millimetric solitary fibrous tumor of the bladder, invisible to radiologic imaging and clinically benign. The case came to our attention because of repeated episodes of renal colic. As opposed to the present case,... Read more
    J Cancer Metastasis Treat 2016;2:388-90. | doi:10.20517/2394-4722.2016.21
    Published on: 30 Sep 2016  | Viewed:774  | Downloaded:76
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  • Original Article|Open Access

    Do elderly NSCLC stage IV patients benefit from chemotherapy as well as younger? An analysis from clinical practice date

    Regina Gironés , Pedro López , Rebeca Chulvi , Mamen Cañabate
    Aim: The aim of this study was to evaluate the efficacy of treatment related to age in metastatic non-small cell lung cancer (NSCLC). We compared young and elders (> 70) in the setting of a regional Spanish hospital. We hypothesized that elder benefit as much as younger patients from... Read more
    J Cancer Metastasis Treat 2016;2:379-87. | doi:10.20517/2394-4722.2016.20
    Published on: 30 Sep 2016  | Viewed:1159  | Downloaded:88
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  • Review|Open Access

    Function of cancer cell-derived extracellular matrix in tumor progression

    Gao-Feng Xiong , Ren Xu
    Extracellular matrix (ECM) is an essential component of the tumor microenvironment. Cancer development and progression are associated with increased ECM deposition and crosslink. The chemical and physical signals elicited from ECM are necessary for cancer cell proliferation and invasion. It is... Read more
    J Cancer Metastasis Treat 2016;2:357-64. | doi:10.20517/2394-4722.2016.08
    Published on: 18 Sep 2016  | Viewed:13355  | Downloaded:513
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  • Review|Open Access

    The features of peritoneal metastases from gastric cancer

    Gianni Mura , Beatrice Verdelli
    Peritoneal Carcinomatosis (PC) from metastasization of Gastric Cancer (GC), either present at first diagnosis of GC or as recurrence, is considered a fatal disease with no hope of definitive cure. Although newer agents like S1 and docetaxel have shown some promise, the median overall survival... Read more
    J Cancer Metastasis Treat 2016;2:365-74. | doi:10.20517/2394-4722.2016.19
    Published on: 18 Sep 2016  | Viewed:6023  | Downloaded:352
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  • Case Report|Open Access

    Pediatric gliomatosis cerebri presenting with intratumoral hemorrhage leading to poor outcome

    Hiromasa Adachi , Masashi Kitagawa , Toshinari Kawasaki , Takafumi Wataya
    Gliomatosis cerebri (GC) is an uncommon disease, defined as diffuse infiltration of neoplastic glial cells involving at least three cerebral lobes. GCs in young population are rare. We described a case of 14-year-old woman with GC who did not receive any recommended treatment, because the... Read more
    J Cancer Metastasis Treat 2016;2:375-8. | doi:10.20517/2394-4722.2016.33
    Published on: 18 Sep 2016  | Viewed:766  | Downloaded:83
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  • Topic: Neuroendocrine Tumors|Open Access

    Circulating neuroendocrine tumors biomarkers. Why? When? How? Suggestions for clinical practice from guidelines and consensus

    Paola Razzore , Giorgio Arnaldi
    Neuroendocrine neoplasms (NETs) are rare tumors that are increasing in incidence. NETs are characterized by heterogeneous biological behaviour, clinical presentation and course. A sensitive and specific diagnostic and prognostic circulating biomarker useful for all sites, grading and staging of... Read more
    J Cancer Metastasis Treat 2016;2:348-56. | doi:10.20517/2394-4722.2016.39
    Published on: 31 Aug 2016  | Viewed:2226  | Downloaded:298
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  • Topic: Neuroendocrine Tumors|Open Access

    Pancreatic neuroendocrine tumor with hypoglycemia and elevated insulin-like growth factor II: a case report

    Roberta Modica , Antonella Di Sarno , Annamaria Colao , Antongiulio Faggiano
    Pancreatic neuroendocrine tumors (pNETs) can be associated with different clinical syndromes. Insulinoma is the most common functioning pNET characterized by hypoglycemia and hyperinsulinemia. The authors report a case of a man presenting with hypoglycemia and biochemical features of insulinoma.... Read more
    J Cancer Metastasis Treat 2016;2:345-7. | doi:10.20517/2394-4722.2016.44
    Published on: 31 Aug 2016  | Viewed:759  | Downloaded:128
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  • Topic: Neuroendocrine Tumors|Open Access

    Orbital lesions, an exceedingly rare site of neuroendocrine tumor metastasis

    Sara Pusceddu , Massimo Milione , Silvia Ortolani , Alessio Pellegrinelli , Marco Brugia , Filippo de Braud , Lorenzo Antonuzzo
    Neuroendocrine tumors are rare neoplasms arising primarily in the gastrointestinal tract and lung. The liver is the most common site of metastases, but these tumors can rarely metastasize to atypical sites. Surgery is the only curative approach while the optimal medical treatment is debated. From... Read more
    J Cancer Metastasis Treat 2016;2:341-4. | doi:10.20517/2394-4722.2016.41
    Published on: 31 Aug 2016  | Viewed:970  | Downloaded:110
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  • Topic: Neuroendocrine Tumors|Open Access

    Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

    Mariangela Torniai , Silvia Rinaldi , Francesca Morgese , Giulia Ricci , Azzurra Onofri , Christian Grohé , Rossana Berardi
    Neuroendocrine tumors (NETs) represent a spectrum of rare neoplasms arising in different organism sites. Depending on the site of onset, they also can be distinguished using lab exams (secreting vs. nonsecreting), clinical symptoms (functioning vs. nonfunctioning), behavioral, morphological... Read more
    J Cancer Metastasis Treat 2016;2:329-40. | doi:10.20517/2394-4722.2016.47
    Published on: 31 Aug 2016  | Viewed:2325  | Downloaded:153
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  • Topic: Neuroendocrine Tumors|Open Access

    Double tracer PET/CT: what is it and what does it mean?

    Mattia Pellicciari , Silvia Ortolani , Elisabetta Grego , Giampaolo Tortora , Sara Cingarlini
    68Ga-DOTA-peptide PET/CT is a recommended imaging modality in the workup of neuroendocrine neoplasms (NENs), which shows high diagnostic sensitivity and is a strong predictor of successful somatostatin receptor directed treatments. Although not routinely recommended, reliable evidences show that... Read more
    J Cancer Metastasis Treat 2016;2:321-8. | doi:10.20517/2394-4722.2016.45
    Published on: 31 Aug 2016  | Viewed:636  | Downloaded:103
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  • Topic: Neuroendocrine Tumors|Open Access

    Review of recent advances in medical treatment for neuroendocrine neoplasms: somatostatin analogs and chemotherapy

    Francesca Spada , Monica Valente
    Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare tumours often producing high levels of hormones and causing symptoms. There are a number of different types of NENs. They usually arise as advanced and low/intermediate grade only in a minority of cases, as high grade. Treatment... Read more
    J Cancer Metastasis Treat 2016;2:313-20. | doi:10.20517/2394-4722.2016.38
    Published on: 31 Aug 2016  | Viewed:6262  | Downloaded:325
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  • Topic: Neuroendocrine Tumors|Open Access

    Merkel cell carcinoma responsive to Etoposide: a case report and brief literature review

    Chiara Ancona , Andrea Caff , Giovanni Manfredi Assanto , Stefano Cordio
    Merkel cell carcinoma (MCC), first described in 1972, is an aggressive primary cutaneous carcinoma able to incorporate both epithelial and neuroendocrine features. MCC mainly appears in individuals in their eighth decade and it is related to a high mortality rate. The etiology of this rare... Read more
    J Cancer Metastasis Treat 2016;2:310-2. | doi:10.20517/2394-4722.2016.46
    Published on: 17 Aug 2016  | Viewed:1306  | Downloaded:82
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  • Topic: Neuroendocrine Tumors|Open Access

    Controversies in the treatment of digestive neuroendocrine tumors

    Maria Rinzivillo , Francesco Panzuto , Gianfranco Delle Fave
    Gastroenteropancreatic neuroendocrine tumors (NETs) have an incidence of 2.39 per 100,000 inhabitants per year, and a prevalence of 35 cases per 100,000 inhabitants; the gap between these rates is due to the relatively long survival time of these tumors, which can be thus considered as chronic... Read more
    J Cancer Metastasis Treat 2016;2:304-9. | doi:10.20517/2394-4722.2016.40
    Published on: 17 Aug 2016  | Viewed:686  | Downloaded:120
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  • Topic: Neuroendocrine Tumors|Open Access

    Management of hepatic metastases of well/moderately differentiated neuroendocrine tumors of the digestive tract

    Anna La Salvia , Stefano Partelli , Marco Tampellini , Domenico Tamburrino , Massimo Falconi , Giorgio V. Scagliotti , Maria Pia Brizzi
    In neuroendocrine tumors (NETs), liver metastases (LM) represent the most crucial prognostic factor, irrespective of the primary tumor site. At diagnosis, about 65-95% of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show hepatic metastasis. Management strategies of LM are heterogeneous... Read more
    J Cancer Metastasis Treat 2016;2:294-303. | doi:10.20517/2394-4722.2016.37
    Published on: 17 Aug 2016  | Viewed:1249  | Downloaded:205
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  • Topic: Neuroendocrine Tumors|Open Access

    Neuroendocrine tumors: current therapies, notch signaling, and cancer stem cells

    Judy S. Crabtree , Lucio Miele
    Neuroendocrine tumors (NETs) encompass a broad spectrum of malignancies all derived from neuroendocrine cell lineage, affecting many different organs including the gastrointestinal (GI) tract, the endocrine pancreas, the thyroid, the skin and the respiratory tract. These tumors as a group are... Read more
    J Cancer Metastasis Treat 2016;2:279-93. | doi:10.20517/2394-4722.2016.30
    Published on: 17 Aug 2016  | Viewed:1442  | Downloaded:250
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  • Topic: Neuroendocrine Tumors|Open Access

    Neuroendocrine tumors: a multidisciplinary approach for a complex disease

    Rossana Berardi
    J Cancer Metastasis Treat 2016;2:277-8. | doi:10.20517/2394-4722.2016.50
    Published on: 17 Aug 2016  | Viewed:2167  | Downloaded:176
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  • Original Article|Open Access

    Oxidative stress and breast cancer biomarkers: the case of the cytochrome P450 2E1

    Subir Singh , Ramkumar Rajendran , Kengo Kuroda , Emiko Isogai , Marija Krstic-Demonacos , Constantinos Demonacos
    Aim: The aim of the study is to investigate the impact of the cytochrome P450 2E1, which is the most efficient CYP450 family member in generating reactive oxygen species (ROS), on cellular energy metabolism of breast cancer cells and therefore the effects of CYP2E1 on breast carcinogenesis.... Read more
    J Cancer Metastasis Treat 2016;2:268-76. | doi:10.20517/2394-4722.2016.42
    Published on: 29 Jul 2016  | Viewed:2949  | Downloaded:292
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  • Original Article|Open Access

    Evaluation of anti-metastatic effect of chitosan nanoparticles on esophageal cancer-associated fibroblasts

    Pravin D. Potdar , Aashutosh U. Shetti
    Aim: Esophageal cancer is one of the major types of cancers, causing death of approximately 5% of all cancer deaths. This is due, in large part, to both relatively ineffectual and unavailable treatment. In order to develop an effective treatment strategy against esophageal cancer, it is important... Read more
    J Cancer Metastasis Treat 2016;2:259-67. | doi:10.20517/2394-4722.2016.25
    Published on: 29 Jul 2016  | Viewed:1841  | Downloaded:152
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  • Case Report|Open Access

    Malignant eccrine acrospiroma with nodal and bone metastasis

    Burhan Wani , Shiekh Aejaz Aziz , Mohmad Hussain Mir , Gull Mohammad Bhat , Abdul Rashid Lone
    Acrospiromas are cutaneous tumors of sweat duct differentiation. Although various eccrine sweat gland tumours including benign acrospiroma are widely reviewed, malignant acrospiroma is rarely reported. Clinically, they resemble other cutaneous lesions and the primary treatment is wide local... Read more
    J Cancer Metastasis Treat 2016;2:255-8. | doi:10.20517/2394-4722.2015.92
    Published on: 20 Jul 2016  | Viewed:1263  | Downloaded:81
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  • Case Report|Open Access

    EGFR mutation--a commonly neglected mutation in squamous cell lung carcinoma

    Rajeev Saini , Ullas Batra , Akhil Jain , Chaturbhuj Agrawal
    Lung cancer is the leading cause of cancer-related death worldwide. Advances in molecular biology have unveiled various targetable mutations with epidermal growth factor receptor (EGFR) being most common. EGFR testing is recommended for all locally advanced or metastatic adenocarcinoma lungs but... Read more
    J Cancer Metastasis Treat 2016;2:253-4. | doi:10.20517/2394-4722.2016.07
    Published on: 20 Jul 2016  | Viewed:1467  | Downloaded:150
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Curcumin sensitizes quiescent leukemic cells to antimitotic drug 5-fluorouracil by inducing proliferative responses in them

    Anagha Gardane , Mariyah Poonawala , Anuradha Vaidya
    Long-term quiescence or dormancy is a fundamental feature of cancer stem cells (CSCs) that are genetically identical to the malignant clone but constitute the only cells with tumor propagation potential within the overall tumor population. These quiescent cells show significant resistance to... Read more
    J Cancer Metastasis Treat 2016;2:245-52. | doi:10.20517/2394-4722.2016.11
    Published on: 8 Jul 2016  | Viewed:2153  | Downloaded:202
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    The quintessential quiescence of cancer stem cells: a struggle towards better treatment

    Anuradha Vaidya
    J Cancer Metastasis Treat 2016;2:243-4. | doi:10.20517/2394-4722.2016.10
    Published on: 8 Jul 2016  | Viewed:637  | Downloaded:134
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Therapeutic strategies for targeting cancer stem cells

    Yu Jeong Kim , Elizabeth L. Siegler , Natnaree Siriwon , Pin Wang
    The therapeutic limitations of conventional chemotherapeutic drugs present a challenge for cancer therapy; these shortcomings are largely attributed to the ability of cancer cells to repopulate and metastasize after initial therapies. Compelling evidence suggests that cancer stem cells (CSCs)... Read more
    J Cancer Metastasis Treat 2016;2:233-42. | doi:10.20517/2394-4722.2016.26
    Published on: 8 Jul 2016  | Viewed:9404  | Downloaded:926
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Introduction to the Special Issue “Cancer Stem Cells: Impact on Treatment”

    Ira-Ida Skvortsova
    J Cancer Metastasis Treat 2016;2:231-2. | doi:10.20517/2394-4722.2016.35
    Published on: 8 Jul 2016  | Viewed:823  | Downloaded:158
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  • Review|Open Access

    Changing paradigm in treatment of lung cancer

    Sundaram Viswanath , Abhishek Pathak , Amul Kapoor , Anvesh Rathore , Bhupendra Nath Kapur
    Lung cancer is one of the most common and deadliest forms of cancer. It accounts for 13% of all new cancer cases and 19% of cancer-related deaths. In India, lung cancer constitutes 6.9% of all new cancer cases and 9.3% of all cancer cases. There has also been a dramatic rise worldwide in both the... Read more
    J Cancer Metastasis Treat 2016;2:214-9. | doi:10.20517/2394-4722.2015.88
    Published on: 15 Jun 2016  | Viewed:746  | Downloaded:204
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  • Case Report|Open Access

    Carcinoma cervix with fat attenuating skull metastases

    Anuradha Kapali , Atmakuri Sateesh Kumar , Mukunda Malathi , S. D. Shamsundar
    Skeletal metastasis in carcinoma cervix occurs in about 0.8-23% of cases. These lesions are usually radiographically lytic. Very few cases of metastases to the skull have been identified, about 5 cases to the best of our knowledge. We present a case of adenosquamous cell carcinoma of cervix with... Read more
    J Cancer Metastasis Treat 2016;2:228-30. | doi:10.20517/2394-4722.2015.87
    Published on: 15 Jun 2016  | Viewed:1393  | Downloaded:91
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  • Review|Open Access

    The role of human papillomaviruses in cancer progression

    Pinar Tulay , Nedime Serakinci
    The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers... Read more
    J Cancer Metastasis Treat 2016;2:201-13. | doi:10.20517/2394-4722.2015.67
    Published on: 15 Jun 2016  | Viewed:2516  | Downloaded:261
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  • Case Report|Open Access

    An unusual case of encapsulated papillary carcinoma of breast

    Kriti Chauhan , Monika Garg
    Intracystic (encapsulated) papillary carcinoma of breast is a rare variant of breast cancer. It is usually a low-grade tumor showing estrogen, progesterone positivity. The authors report an unusual case of intracystic papillary carcinoma showing high nuclear grade, brisk mitosis, and necrosis... Read more
    J Cancer Metastasis Treat 2016;2:224-7. | doi:10.20517/2394-4722.2015.63
    Published on: 15 Jun 2016  | Viewed:5251  | Downloaded:160
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  • Review|Open Access

    Muscarinic receptor signaling and colon cancer progression

    Guofeng Xie , Jean-Pierre Raufman
    Due to the lack of effective treatments, advanced colorectal cancer (CRC) remains a leading cause of cancer death in the United States. Emerging evidence supports the observation that muscarinic receptor (MR) signaling plays a critical role in growth and progression of CRC. MR activation by... Read more
    J Cancer Metastasis Treat 2016;2:195-200. | doi:10.20517/2394-4722.2016.05
    Published on: 15 Jun 2016  | Viewed:4361  | Downloaded:161
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  • Case Report|Open Access

    Osteonecrosis of the jaw in a patient with acute myeloid leukemia, who received azacitidine

    Ourania Nicolatou-Galitis , Dimitra Galiti , Maria Moschogianni , Sotirios Sachanas , Beatrice J. Edwards , Cesar A. Migliorati , Gerassimos Pangalis
    The first case of osteonecrosis of the jaw (ONJ) related to azacitidine therapy was reported. A 64-year-old male with acute myeloid leukemia, who received 5-azacitidine, presented with pain and purulence of the right second premolar. An unsuccessful endodontic therapy resulted in dental... Read more
    J Cancer Metastasis Treat 2016;2:220-3. | doi:10.20517/2394-4722.2016.06
    Published on: 15 Jun 2016  | Viewed:1628  | Downloaded:111
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Gemcitabine followed by radiotherapy in treatment of newly diagnosed high-grade gliomas

    Maha El-Naggar , Mervat Omar , Ahmed Elgeriany , Godefridus J. Peters , Amina Mostafa , Samir Shehata
    Aim: High-grade glioblastoma multiforme (GBM) has a poor median overall survival (OS). The standard treatment after surgery is temozolomide and radiotherapy (RTH). Patients with unmethylated methylguanine-methyltransferase promoter (MGMT) have no or little benefit from temozolomide and are... Read more
    J Cancer Metastasis Treat 2016;2:188-94. | doi:10.20517/2394-4722.2016.15
    Published on: 18 May 2016  | Viewed:1606  | Downloaded:182
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Targeting cerebrospinal fluid for discovery of brain cancer biomarkers

    Tarek Shalaby , Federica Achini , Michael A. Grotzer
    Central nervous system (CNS) cancer is a devastating illness with unmet therapeutic needs. Establishing biomarkers that have the potential to guide accurate CNS cancer diagnosis or are helpful in predicting disease progression or therapy response is of great interest. Cerebrospinal fluid (CSF)... Read more
    J Cancer Metastasis Treat 2016;2:176-87. | doi:10.20517/2394-4722.2016.12
    Published on: 18 May 2016  | Viewed:16482  | Downloaded:472
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Interdisciplinary management of central nervous system metastasis and neoplastic meningitis: recent developments and future perspectives

    Ghazaleh Tabatabai , Marilin Koch , Cristiana Roggia , Juliane Ebert , Claus Garbe , Friedegund Meier , Sara Brucker , Eva Maria Grischke , Diethelm Wallwiener , Robert Möhle , Lothar Kanz , Walter Erich Auletzky , Ulrike Ernemann , Christian LaFougere , Konstantin Nikolaou , Bernd Pichler , Jens Schittenhelm , Manuela Neumann , Falko Fend , Stefan Czemmel , Sven Nahnsen , Frank Paulsen , Daniel Zips , Maike van Lessen , Hans-Otto Karnath , Ulf Ziemann , Hans-Georg Rammensee , Constantin Roder , Marco Skardelly , Jürgen Bernd Honegger , Marcos Tatagiba
    The incidence of metastatic disease in the central nervous system (CNS) is rising. According to current estimates, up to a third of adult cancer patients will suffer from CNS metastasis. Clinical evidence-based data from prospective randomized trials are rare, however, because CNS metastasis... Read more
    J Cancer Metastasis Treat 2016;2:163-75. | doi:10.20517/2394-4722.2016.01
    Published on: 18 May 2016  | Viewed:1836  | Downloaded:125
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Dissecting brain tumor growth and metastasis in vitro and ex vivo

    Michael A. Grotzer , Anuja Neve , Martin Baumgartner
    Local infiltration and distal dissemination of tumor cells hamper efficacy of current treatments against central nervous system (CNS) tumors and greatly influence mortality and therapy-induced long-term morbidity in survivors. A number of in vitro and ex vivo assay systems have been established... Read more
    J Cancer Metastasis Treat 2016;2:149-62. | doi:10.20517/2394-4722.2016.02
    Published on: 18 May 2016  | Viewed:9294  | Downloaded:559
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Introduction to this special issue on brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations

    Michael A. Grotzer
    It is my privilege to introduce the readers to this special issue entitled “Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations”. As cancer is a global epidemic which knows no borders, efforts to better understand biology and to control it should know no... Read more
    J Cancer Metastasis Treat 2016;2:147-8. | doi:10.20517/2394-4722.2016.23
    Published on: 18 May 2016  | Viewed:392  | Downloaded:81
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  • Original Article|Open Access

    The association of the uterine motion with bladder volume during radiotherapy in gynecological malignancies

    Bhandari Virendra , Mutneja Abhinav , Gurjar Omprakash , Saadvik Raghuram , Bagdare Priyusha , Gupta Krishnlal , Singh Kanchan
    Aim: This study was performed to assess the extent of interfraction uterine motion during radiotherapy for cervical cancer and uterine body carcinoma while maintaining a strict bladder filling protocol. Methods: Twenty-four patients with cervical cancer or uterine body carcinoma who were treated... Read more
    J Cancer Metastasis Treat 2016;2:139-43. | doi:10.20517/2394-4722.2015.68
    Published on: 15 Apr 2016  | Viewed:2223  | Downloaded:177
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  • Case Report|Open Access

    Primary malignant melanoma of the spinal cord: a case report

    Ashutosh Das Sharma , Jyoti Poddar , Ubrangala Suryanarayan Kunikullaya , Jay Prakash Neema
    Primary malignant melanoma of the central nervous system is rare, and the events involving the spinal cord are even more infrequent. A 30-year-old male presented with a mass lesion of the spinal cord. After radiological workup, the mass was resected in December 2012. The histopathological... Read more
    J Cancer Metastasis Treat 2016;2:144-6. | doi:10.20517/2394-4722.2015.58
    Published on: 15 Apr 2016  | Viewed:2391  | Downloaded:123
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  • Original Article|Open Access

    The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

    Chrissa Sioka , Thomas Exarchopoulos , Vlasis Skloupiotis , Vaios Papathanassiou , Vasileios Ragos , Maria Argyropoulou , Anna Gousia , Periklis Tsekeris , Georgios Exarchakos , Dimitrios Assimakopoulos , Andreas Fotopoulos
    Aim: To evaluate the diagnostic value of technetium Tc99m-tetrofosmin (99mTc-TF) in primary cancers of the head and neck. Methods: Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12... Read more
    J Cancer Metastasis Treat 2016;2:133-8. | doi:10.20517/2394-4722.2015.65
    Published on: 15 Apr 2016  | Viewed:2193  | Downloaded:113
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  • Case Report|Open Access

    Metachronous bladder metastasis from papillary renal cell carcinoma

    Arun Ramdas Menon , Nivedita Suresh , Prajwal Ravinder , Rajeev Thekke Puthalath
    Renal cell carcinoma (RCC) is well known for its metastatic potential and predilection for unusual sites of metastasis. Metastasis to the bladder is rare and has been reported predominantly from clear cell RCC. We report a case of a 72-year-old male presenting with a bladder tumor which on... Read more
    J Cancer Metastasis Treat 2016;2:130-2. | doi:10.4103/2394-4722.169645
    Published on: 28 Mar 2016  | Viewed:1479  | Downloaded:96
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  • Case Report|Open Access

    Metastatic high-grade neuroendocrine tumor of mandible

    Jitender Batra , Chinmay D. Vakade , Sonal Grover , Gyanander Attresh
    Neuroendocrine tumors of the oral cavity and jaws are exceedingly rare. They include paragangliomas, a melanotic neuroectodermal tumor of infants, small cell carcinomas, and Merckel cell carcinomas. Most have been non-functional in nature. Breast, lung, liver, colon, and prostate are the most... Read more
    J Cancer Metastasis Treat 2016;2:127-9. | doi:10.4103/2394-4722.170022
    Published on: 28 Mar 2016  | Viewed:4291  | Downloaded:108
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  • Case Report|Open Access

    Metastatic breast cancer: an unusual cause of diplopia

    Nasser Mohammed Amer , Gareth Bashir , Arikoge Ogedegbe , Ibtisam Saeed
    While secondary solid cancer into the eye orbit is rare, it is the most common site for primary metastasis in female breast cancer. We report a case of a sixty-six years old woman presenting to her optician with complaints of double vision. Magnetic resonance imaging revealed an invasive lesion... Read more
    J Cancer Metastasis Treat 2016;2:123-6. | doi:10.20517/2394-4722.2016.13
    Published on: 28 Mar 2016  | Viewed:2442  | Downloaded:94
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Tailored nanocarriers and bioconjugates for combating glioblastoma and other brain tumors

    Fatema ELAmrawy , Amr A. Othman , Chris Adkins , Aliaa Helmy , Mohamed I. Nounou
    Worldwide, the incidence of primary brain tumors is on the rise. Unfortunately, noninvasive drug therapy is hampered by poor access of most drugs to the brain due to the insurmountable blood-brain barrier (BBB). Nanotechnology holds great promise for noninvasive therapy of severe brain diseases.... Read more
    J Cancer Metastasis Treat 2016;2:112-22. | doi:10.20517/2394-4722.2015.78
    Published on: 11 Mar 2016  | Viewed:15091  | Downloaded:753
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Effects of Gas1 on gliomas: a review on current preclinical studies

    Jose Segovia , Elizabeth Bautista , Manuel Lara-Lozano
    Glioblastoma multiforme (GBM) is the most common and lethal brain tumor. Its prognosis remains very poor, despite the use of combined treatments such as surgical resection, radiation and chemotherapy. The major limitations for the treatment of GBM are its high invasiveness, tumor recurrence and... Read more
    J Cancer Metastasis Treat 2016;2:101-11. | doi:10.20517/2394-4722.2015.76
    Published on: 11 Mar 2016  | Viewed:3123  | Downloaded:204
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Brain infiltration by cancer cells: different roads to the same target?

    Mayra Paolillo , Sergio Schinelli
    Brain infiltration by cancer cells is a complex process in which metastatic cells detached from the primary tumor must firstly survive in the blood flow, cross the blood brain barrier (BBB) and finally colonize a foreign microenvironment. The cells that successfully bypass the cellular barriers... Read more
    J Cancer Metastasis Treat 2016;2:90-100. | doi:10.4103/2394-4722.172661
    Published on: 11 Mar 2016  | Viewed:1382  | Downloaded:215
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

    Silvia Crespo , Marcus Kind , Alexandre Arcaro
    The PI3K/AKT/mTOR (PAM) pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer progression. It has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children, malignant gliomas... Read more
    J Cancer Metastasis Treat 2016;2:80-9. | doi:10.20517/2394-4722.2015.72
    Published on: 11 Mar 2016  | Viewed:14801  | Downloaded:624
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Brain tumor surgery: supplemental intra-operative imaging techniques and future challenges

    Telmo Augusto Barba Belsuzarri , Raphael Martinelli Anson Sangenis , João Flavio Mattos Araujo
    Modern brain tumor surgery stands in the pillar of maximum safe resection. Tumor borders are always challenging, especially infiltration zones in malignant brain tumors. Novel technologies are designed for a better delineation and to increase the extent of resection (EOR) in brain tumor surgery,... Read more
    J Cancer Metastasis Treat 2016;2:70-9. | doi:10.4103/2394-4722.172249
    Published on: 11 Mar 2016  | Viewed:3036  | Downloaded:250
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  • Case Report|Open Access

    Unusual skeletal muscle metastasis from carcinoma cervix

    Mehlam Kausar , Desh Deepak Ladia , Abhinav Mutneja , Virendra Bhandari
    Cervical cancer is the most common malignancy in Indian women. It usually spreads locally or via regional lymphatics to retroperitoneal lymph nodes and hematogenous spread is rare. The occurrence of skeletal muscle metastases is a very rare event and only a few cases have been reported in... Read more
    J Cancer Metastasis Treat 2016;2:67-9. | doi:10.4103/2394-4722.170545
    Published on: 29 Feb 2016  | Viewed:1255  | Downloaded:97
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  • Case Report|Open Access

    The therapeutic potential of duloxetine in prostate cancer-related fatigue

    Rita De Sanctis , Alessandro Viganò
    Cancer-related fatigue (CRF) is a common polysymptomatic syndrome with no standard therapy. The authors present the case of a prostate cancer patient in whom, during hormone therapy, disabling CRF and urinary incontinence occurred. CRF was assessed according to the brief fatigue inventory (BFI).... Read more
    J Cancer Metastasis Treat 2016;2:64-6. | doi:10.4103/2394-4722.164646
    Published on: 29 Feb 2016  | Viewed:644  | Downloaded:81
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  • Original Article|Open Access

    Prognostic factors and efficacy of GDP-R therapy in refractory/relapsed diffuse large B-cell lymphomas not eligible for high-dose therapy

    Francesco Ghio , Giulia Cervetti , Nadia Cecconi , Matteo Pelosini , Sara Galimberti , Riccardo Morganti , Paola Ferrari , Andrea Nicolini , Mario Petrini
    Aim: The main aim of the present study was to evaluate the overall survival (OS) and time to treatment failure (TTF) in a cohort of relapsed/refractory diffuse large B-cell lymphomas (DLBCLs) not eligible for high-dose therapy (HDT) treated with gemcitabine in association with dexamethasone,... Read more
    J Cancer Metastasis Treat 2016;2:59-63. | doi:10.4103/2394-4722.172291
    Published on: 29 Feb 2016  | Viewed:2437  | Downloaded:195
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  • Review|Open Access

    What we have learned from urinary bladder cancer models

    Carina Bernardo , Céu Costa , Carlos Palmeira , Rosário Pinto-Leite , Paula Oliveira , Rui Freitas , Francisco Amado , Lúcio L. Santos
    Urinary bladder cancer (UBC) is a heterogeneous disease with highly variable clinical outcomes and responses to chemotherapy. Despite some advances in the molecular understanding of UBC, this knowledge still has not been translated to the clinic in terms of improvements in the prognosis and... Read more
    J Cancer Metastasis Treat 2016;2:51-8. | doi:10.4103/2394-4722.171279
    Published on: 29 Feb 2016  | Viewed:2136  | Downloaded:394
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  • Review|Open Access

    Molecular and cellular aspects of extramedullary manifestations of acute myeloid leukemia

    Javad Mohammadiasl , Abbas Khosravi , Mohammad Shahjahani , Shirin Azizidoost , Najmaldin Saki
    The myeloid extramedullary tumor is a solid tumor formed by infiltration of immature myeloid cells in various tissues of the body. This tumor is also identified as chloroma or myeloid sarcoma (MS). MS is a manifestation of acute myeloid leukemia (AML) occurring at presentation or during treatment... Read more
    J Cancer Metastasis Treat 2016;2:44-50. | doi:10.4103/2394-4722.167230
    Published on: 29 Feb 2016  | Viewed:5704  | Downloaded:226
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  • Review|Open Access

    The farnesoid X receptor and colon cancer

    Guofeng Xie , Jean-Pierre Raufman
    Worldwide, colorectal cancer (CRC) is a leading cause of cancer death, primarily because of limited therapeutic options for those with advanced disease. The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. Besides its prominent... Read more
    J Cancer Metastasis Treat 2016;2:24-8. | doi:10.4103/2394-4722.164288
    Published on: 15 Jan 2016  | Viewed:851  | Downloaded:176
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  • Review|Open Access

    Roles of dysregulated Notch pathway and small DNA tumor viruses in cancer initiation and progression

    Anthony G. Clementz , Paola Rizzo , Fernanda Martini , Mauro Tognon
    Notch pathway is a major determinant of cell fate, and research within the last 30 years has shown dysfunctions within this pathway in the majority of solid tumors and leukemias. The molecular mechanisms causing aberrant expression of Notch in cancer are still partially known. Mesotheliomas,... Read more
    J Cancer Metastasis Treat 2016;2:11-23. | doi:10.4103/2394-4722.171982
    Published on: 15 Jan 2016  | Viewed:1976  | Downloaded:153
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  • Review|Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo
    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development... Read more
    J Cancer Metastasis Treat 2016;2:1-10. | doi:10.4103/2394-4722.171829
    Published on: 15 Jan 2016  | Viewed:202682  | Downloaded:640
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  • Original Article|Open Access

    Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model

    Lai-Lei Ting , Andy Shau-Bin Chou , Chin-Hsuan Hsieh , Shih-Chieh Hsiung , See-Tong Pang , Shuen-Kuei Liao
    Aim: As our understanding of cancer stem cell (CSC) biology improves, search for inhibitory agents of CSCs and metastatic CSCs (mCSCs) positive for CXCR4 is warranted. Withaferin A (WA), a withanolide extracted from the medicinal plant Withania somnifera, has been shown to exhibit anti-cancer... Read more
    J Cancer Metastasis Treat 2016;2:29-40. | doi:10.4103/2394-4722.172008
    Published on: 15 Jan 2016  | Viewed:3307  | Downloaded:191
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  • Case Report|Open Access

    Hepatocellular carcinoma presenting as rapidly growing sternal mass: an unusual presentation

    Rahul S. Kulkarni , Asha S. Anand , Apurva A. Patel , Sandip A. Shah
    Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. The most frequent sites of metastases are lungs, regional lymph nodes, adrenals and bones. However, an isolated sternal metastasis from HCC as an initial presentation has been rarely reported. A 45-year-old man... Read more
    J Cancer Metastasis Treat 2016;2:41-3. | doi:10.4103/2394-4722.169643
    Published on: 15 Jan 2016  | Viewed:9716  | Downloaded:107
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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