Articles
  • Review|Open Access

    Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

    Shirley Jusino, Fabiola M. Fernández-Padín, Harold I. Saavedra
    Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:43. | doi:10.20517/2394-4722.2018.24
    Published on: 7 Aug 2018  | Viewed:92  | Downloaded:10
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  • Review|Open Access

    Genomic heterogeneity meets cellular energetics: crosstalk between the mitochondria and the cell cycle

    Erica L. Herrera, Seham Z. Azzam, Madison C. Berger, Laura A. Diaz-Martinez
    Changes in cellular energetics and genomic instability are two characteristics of cancers that have been studied independently. Evidence of cross-talk between mitochondria function and nuclear function has started to emerge, suggesting that these pathways can influence one another. Here we review... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:42. | doi:10.20517/2394-4722.2018.35
    Published on: 6 Aug 2018  | Viewed:115  | Downloaded:14
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  • Original Article|Open Access

    Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity

    Yi-Hong Zhou, Kambiz Afrasiabi, Mark E. Linskey
    Aim: Current cancer treatments are challenged by the plasticity of cancer cells, largely influenced by chromosomal instability (CIN) leading to variations in karyotype known as tumor-specific aneuploidy, which in turn, leads to intra-tumor cellular heterogeneity (TH). Cells with certain... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:41. | doi:10.20517/2394-4722.2018.16
    Published on: 2 Aug 2018  | Viewed:154  | Downloaded:21
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  • Review|Open Access

    Robotic gastrectomy for gastric cancer

    Masanori Tokunaga, Masahiro Watanabe, Shizuki Sugita, Akiko Tonouchi, Akio Kaito, Takahiro Kinoshita
    Robotic gastrectomy (RG) is increasingly performed, particularly in East Asia. With articulated devices, surgeons are able to perform every procedure more comfortably and meticulously, which makes RG ideal from the surgeon’s standpoint. However, it is still unclear whether it is a suitable... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:40. | doi:10.20517/2394-4722.2017.80
    Published on: 30 Jul 2018  | Viewed:181  | Downloaded:77
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  • Review|Open Access

    Molecular mechanism of peritoneal dissemination in gastric cancer

    Qing-Jiang Hu, Shuhei Ito, Kazuyoshi Yanagihara, Koshi Mimori
    Peritoneal dissemination (PD) is the most common cause of metastasis in gastric cancer (GC). Because there are no standard treatments for PD, it is associated with a poor prognosis. Although clinicians have performed intraperitoneal chemotherapy for GC with PD, the outcome remains unsatisfactory.... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:39. | doi:10.20517/2394-4722.2018.08
    Published on: 26 Jul 2018  | Viewed:234  | Downloaded:105
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  • Review|Open Access

    Laparoscopic personalized function-preserving gastrectomy with sentinel node mapping for early-stage gastric cancer

    Hiroya Takeuchi, Yuko Kitagawa
    Laparoscopic gastrectomy is considered as an indispensable option between endoscopic resection and standard gastrectomy with open laparotomy for patients with early-stage gastric cancer. However, the extent of gastrectomy and remnant gastric function may affect patients’ quality of life (QOL)... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:38. | doi:10.20517/2394-4722.2017.83
    Published on: 23 Jul 2018  | Viewed:137  | Downloaded:105
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  • Original Article|Open Access

    New insights into the role of intra-tumor genetic heterogeneity in carcinogenesis: identification of complex single gene variance within tumors

    Bruce Gottlieb, Farbod Babrzadeh, Kathleen Klein Oros, Carlos Alvarado, Chunlin Wang, Baback Gharizadeh, Mark Basik, Celia M.T. Greenwood, Lenore K. Beitel, Mark Trifiro
    Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific driver gene mutations cause carcinogenesis. The discovery of intra-tumor genetic heterogeneity (ITGH), has resulted in this hypothesis being modified by assuming that most of these ITGH mutations are... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:37. | doi:10.20517/2394-4722.2018.26
    Published on: 19 Jul 2018  | Viewed:288  | Downloaded:28
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  • Review|Open Access

    Circulating microRNAs as a liquid biopsy: a next-generation clinical biomarker for diagnosis of gastric cancer

    Shuhei Komatsu, Jun Kiuchi, Taisuke Imamura, Daisuke Ichikawa, Eigo Otsuji
    Accumulating evidence has suggested the potential clinical utility of novel body fluid biomarkers, or “liquid biopsy”, using circulating tumor cells and cell-free nucleic acids from cancer patients. Noninvasive and reproducible, liquid biopsy could provide the basis for individualized therapeutic... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:36. | doi:10.20517/2394-4722.2017.58
    Published on: 18 Jul 2018  | Viewed:182  | Downloaded:74
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  • Review|Open Access

    Current trends in gastric cancer treatment in Europe

    Satoshi Kamiya, Ioannis Rouvelas, Mats Lindblad, Magnus Nilsson
    Gastric cancer is one of the major causes of cancer-related deaths, despite the gradual decrease of its incidence in the West. Minimally invasive procedures, such as endoscopic resection and laparoscopic gastrectomy, have been successfully introduced in European high-volume centres, in the... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:35. | doi:10.20517/2394-4722.2017.76
    Published on: 17 Jul 2018  | Viewed:432  | Downloaded:102
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  • Systematic Review|Open Access

    Surgical treatment of stage IV gastric cancer: is it worthwhile?

    Ilaria Pergolini, Paolo Ciano, Gianluca Guercioni, Marco Catarci
    Aim: To analyze clinical features and survival outcomes of patients with surgically-treated stage IV gastric cancer, in order to evaluate the suitability of surgery in these patients. Methods: We performed a systematic literature search using PubMed, MEDLINE, and Embase on October 9th, 2017.... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:33. | doi:10.20517/2394-4722.2017.84
    Published on: 17 Jul 2018  | Viewed:371  | Downloaded:78
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  • Case Report|Open Access

    Necrotizing fasciitis as a complication of taxanes: a case report

    Nasser Mohammed Amer, Rabia Niaz
    Necrotizing fasciitis is a rare complication of chemotherapy, however, few reports were published as a specific complication of taxanes. We are reporting this rare complication of a lady who was treated with taxanes as an adjuvant therapy for her breast cancer who was referred to us from the... Read more
    J Cancer Metastasis Treat 2018;4:34. | doi:10.20517/2394-4722.2018.09
    Published on: 17 Jul 2018  | Viewed:222  | Downloaded:19
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  • Review|Open Access

    Circulating tumor cells in gastric cancer

    Kenichi Nakamura, Masaaki Iwatsuki, Junji Kurashige, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba
    Circulating tumor cells (CTCs) have received a lot of attention as a novel biomarker for cancer research in past decades. CTCs infiltrate the bloodstream derived from the primary tumor, and are significantly involved in cancer metastasis and recurrence. Although clinical applications have been... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:32. | doi:10.20517/2394-4722.2017.78
    Published on: 5 Jul 2018  | Viewed:280  | Downloaded:166
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  • Review|Open Access

    Update on targeted therapy and immune therapy for gastric cancer, 2018

    Yuki Kiyozumi, Masaaki Iwatsuki, Kohei Yamashita, Yuki Koga, Naoya Yoshida, Hideo Baba
    Gastric cancer (GC) remains one of the most common cancers and serious health problems worldwide. For unresectable or metastatic advanced gastric cancer, chemotherapy treatment is first selected. Although chemotherapy has improved survival in patients with advanced gastric cancer (AGC), the... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:31. | doi:10.20517/2394-4722.2017.77
    Published on: 28 Jun 2018  | Viewed:872  | Downloaded:170
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  • Review|Open Access

    Pancreatic cancer: treatment approaches and trends

    Nabyla Paixão Pereira, José Raimundo Corrêa
    Pancreatic cancer is one of the most challenging diseases due to its often late diagnose which results in limited therapeutic options and poor prognosis. To date, the only curative treatment is complete tumor removal surgery but only a few patients are eligible to do it. The median survival... Read more
    J Cancer Metastasis Treat 2018;4:30. | doi:10.20517/2394-4722.2018.13
    Published on: 25 Jun 2018  | Viewed:449  | Downloaded:45
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  • Editorial|Open Access

    Bioconjugate structures vs. composite nanoparticulate carriers: the battle for the future of smart, effective and safe cancer management

    Mohamed Ismail Nounou
    J Cancer Metastasis Treat 2018;4:29. | doi:10.20517/2394-4722.2018.18
    Published on: 21 Jun 2018  | Viewed:300  | Downloaded:36
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  • Review|Open Access

    Immunotherapy in the treatment of colorectal cancer: a new kid on the block

    Andrea Spallanzani, Fabio Gelsomino, Francesco Caputo, Chiara Santini, Kalliopi Andrikou, Giulia Orsi, Margherita Rimini, Stefania Pipitone, Laura Riggi, Camilla Bardasi, Massimiliano Salati, Stefano Cascinu
    In the last few years, the success of anti-PD1 and anti-PDL1 drugs in solid cancers treatment and the advances in molecular biology have provided new potential treatment strategies for patients with metastatic colorectal cancer. Unfortunately, only patients with mismatch repair deficiency seem to... Read more
    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment
    J Cancer Metastasis Treat 2018;4:28. | doi:10.20517/2394-4722.2018.31
    Published on: 19 Jun 2018  | Viewed:1008  | Downloaded:136
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  • Commentary|Open Access

    Cancer, circulating tumor cells, and metastasis: could protein-derived peptide fragments impede brain metastases?

    Gerald J. Mizejewski
    The majority of cancer deaths can be attributed to cancer cell metastases that migrate to distant target organs. Brain metastases constitute one of the leading causes of morbidity and mortality among cancer patients, occurring in about 40% of patients with metastatic disease. Thus, there exists... Read more
    J Cancer Metastasis Treat 2018;4:27. | doi:10.20517/2394-4722.2018.20
    Published on: 11 Jun 2018  | Viewed:783  | Downloaded:56
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  • Review|Open Access

    Pancreaticoduodenectomy for gastric cancer

    Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
    Pancreaticoduodenectomy (PD) is performed to achieve an R0 resection for gastric cancer with pancreatic and/or duodenal invasion. Several retrospective case series have been published, but the sample cohorts in each study were heterogeneous and small. Moreover, the absence of prospective studies... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:26. | doi:10.20517/2394-4722.2018.15
    Published on: 7 Jun 2018  | Viewed:241  | Downloaded:24
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  • Original Article|Open Access

    Anti-oxidation properties of leaves, skin, pulp, and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells

    Shrefa A. Hadadi, Haiwen Li, Reza Rafie, Paul Kaseloo, Sarah M. Witiak, Rafat A. Siddiqui
    Aim: Breast cancer is typically detected either during a screening examination or after a woman notices a lump. Breast cancers have different phenotypes depending on the presence/absence of an estrogen receptor (ER) and/or an epidermal growth factor (Her-2) receptor. The objective of the present... Read more
    J Cancer Metastasis Treat 2018;4:25. | doi:10.20517/2394-4722.2018.22
    Published on: 30 May 2018  | Viewed:401  | Downloaded:20
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  • Review|Open Access

    Management of metastatic esophagogastric junction adenocarcinoma

    Tasuku Toihata, Yu Imamura, Masayuki Watanabe, Hideo Baba
    The prognosis of metastatic disease of esophagogastric junction adenocarcinoma remains poor, despite using a variety of regimens using cytotoxic agents. Recent understanding of molecular characteristic and tumor microenvironment of this cancer is currently instigating new therapeutic options. In... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:24. | doi:10.20517/2394-4722.2017.82
    Published on: 17 May 2018  | Viewed:464  | Downloaded:32
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  • Review|Open Access

    Treatment strategy for metastatic gastric cancer in Japan

    Kojiro Eto, Satoshi Ida, Masayuki Watanabe, Hideo Baba
    Despite recent progress in diagnostic imaging, gastric cancer (GC) is occasionally found at an advanced stage with distant metastasis. As metastatic GC is difficult to cure, the treatment strategy should be considered individually based on the physical and socioeconomic status of patients as well... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:23. | doi:10.20517/2394-4722.2017.73
    Published on: 16 May 2018  | Viewed:545  | Downloaded:66
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  • Review|Open Access

    Conversion surgery for stage IV gastric cancer

    Satoshi Ida, Masayuki Watanabe
    Gastric cancer with distant metastases, such as para-aortic lymph node metastases, hepatic metastases, and peritoneal dissemination, is classified as stage IV. In this situation, cancer cells have formed micrometastases throughout the body; therefore, according to the algorithm of the Japanese... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:22. | doi:10.20517/2394-4722.2017.75
    Published on: 16 May 2018  | Viewed:561  | Downloaded:87
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  • Original Article|Open Access

    The combined analysis of solid and liquid biopsies provides additional clinical information to improve patient care

    Ana Finzel, Helen Sadik, Gregori Ghitti, Jean-François Laes
    Aim: To investigate if the genetic information provided by sequencing of both solid and liquid biopsies can shed light on tumor heterogeneity, and to understand the clinical usefulness of adding blood profiling to standard tissue analysis in cancer care. Methods: Data from 351 patients with stage... Read more
    J Cancer Metastasis Treat 2018;4:21. | doi:10.20517/2394-4722.2018.10
    Published on: 8 May 2018  | Viewed:1095  | Downloaded:74
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  • Letter|Open Access

    Hypoxia in prostate cancer

    Peter Vaupel
    J Cancer Metastasis Treat 2018;4:20. | doi:10.20517/2394-4722.2018.30
    Published on: 7 May 2018  | Viewed:238  | Downloaded:41
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  • Review|Open Access

    The role of long noncoding RNAs in cancer metastasis

    Christine Parsons, Alexis M. Tayoun, Benjamin D. Benado, Gabriel Ragusa, Rose F. Dorvil, Elizabeth A. Rourke, Kaitlyn O’ Connor, Irene G. Reed, Angela Alexander, Lian Willetts, Maryam Habibian, Brian D. Adams
    Signaling pathways are tightly controlled systems that regulate the appropriate timing of gene expression required for the differentiation of cells down a particular lineage essential for proper tissue development. Proliferation, apoptosis and metabolic pathways are just a few examples of the... Read more
    J Cancer Metastasis Treat 2018;4:19. | doi:10.20517/2394-4722.2018.11
    Published on: 28 Apr 2018  | Viewed:1107  | Downloaded:101
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  • Review|Open Access

    Recent trend in gastric cancer treatment in the USA

    Kazuto Harada, Hideo Baba, Jaffer A. Ajani
    Gastric adenocarcinoma (GAC) is estimated as the fifteenth most common cancer in the USA. Incidence rate has been gradually decreasing, but prognosis remains dismal. For patients with locally advanced GAC (stage > T1B and < T4B), multimodality therapies, such as surgery, chemotherapy, and... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:18. | doi:10.20517/2394-4722.2017.74
    Published on: 26 Apr 2018  | Viewed:745  | Downloaded:70
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  • Review|Open Access

    Prostate cancer cells at a therapeutic gunpoint of the autophagy process

    Fabio Gabriele, Carolina Martinelli, Sergio Comincini
    In a normal prostate, the process of controling cell death is essential to maintain tissue homeostasis and its inhibition may lead to the development of cancer. Androgen receptor signaling plays pivotal roles in the prostate development and homeostasis as well as in the progression of prostate... Read more
    This article belongs to the Special Issue Autophagy and Cancer: current biology and drug development
    J Cancer Metastasis Treat 2018;4:17. | doi:10.20517/2394-4722.2018.06
    Published on: 19 Apr 2018  | Viewed:711  | Downloaded:52
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  • Meta-Analysis|Open Access

    The potential prognostic and predictive roles of programmed cell death protein 1 expressed by tumor-infiltrating lymphocytes in solid tumors: a meta-analysis

    Dong-Yun Zhang, Rong-Zhi Liu, Jian-Wei Ku, Yu-Hong Ma, Ying-Jie Yi
    Aim: Several previous studies have evaluated the potential role of programmed cell death protein 1 (PD-1) expressed by tumor-infiltrating lymphocytes (TILs) in various solid tumors and performed its prognosis role in patients’ survival with inconsistent results. This study aims to further... Read more
    J Cancer Metastasis Treat 2018;4:16. | doi:10.20517/2394-4722.2018.01
    Published on: 12 Apr 2018  | Viewed:761  | Downloaded:87
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  • Original Article|Open Access

    Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

    Edgar Salas, Pedro Sanchez, Juan Postigo, Carlos A. Castaneda, Miluska Castillo, Valeria Villegas, Luis Cano, Sandro Casavilca, Luis A. Bernabe, Carolina Belmar, Maria R. Villa-Robles, Raul Mantilla, Henry Guerra
    Aim: Upper alveolar ridge and hard palate squamous cancer is an infrequent malignancy. We evaluated factors associated with neck involvement and with p16-staining. Methods: Head and neck squamous-cell carcinoma (SCC) patients who went to Head and Neck Department between 1997 and 2011 were... Read more
    J Cancer Metastasis Treat 2018;4:15. | doi:10.20517/2394-4722.2017.66
    Published on: 28 Mar 2018  | Viewed:804  | Downloaded:51
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  • Review|Open Access

    The magnitude of benefit from adding taxanes to anthracyclines in the adjuvant settings of breast cancer: discussion of large trials and meta-analyses

    Osama H. Elzaafarany, Atlal Abusanad
    The taxanes family of chemotherapy, which includes paclitaxel and docetaxel, has been incorporated in the adjuvant breast cancer treatments since 1990s. Sequential and concurrent use of taxanes was investigated with anthracyclines in many adjuvant early breast cancer randomized clinical trials.... Read more
    J Cancer Metastasis Treat 2018;4:14. | doi:10.20517/2394-4722.2017.55
    Published on: 15 Mar 2018  | Viewed:775  | Downloaded:68
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  • Commentary|Open Access

    Targeting adenosine receptor 2B in triple negative breast cancer

    Carola A. Neumann, Kevin Levine, Steffi Oesterreich
    J Cancer Metastasis Treat 2018;4:13. | doi:10.20517/2394-4722.2017.60
    Published on: 15 Mar 2018  | Viewed:1114  | Downloaded:83
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  • Review|Open Access

    Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives

    Francesca Battaglin, Alberto Puccini, Madiha Naseem, Marta Schirripa, Martin D. Berger, Ryuma Tokunaga, Michelle McSkane, Taline Khoukaz, Shivani Soni, Wu Zhang, Heinz-Josef Lenz
    The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with the introduction of novel targeted agents and new therapeutic strategies for the metastatic disease. An extensive effort has been directed to the identification of predictive biomarkers to aid patients... Read more
    This article belongs to the Special Issue Cancer Pharmacogenomics
    J Cancer Metastasis Treat 2018;4:12. | doi:10.20517/2394-4722.2018.04
    Published on: 7 Mar 2018  | Viewed:1578  | Downloaded:157
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  • Review|Open Access

    Current challenges and opportunities in treating hypoxic prostate tumors

    Declan J. McKenna, Rachel Errington, Klaus Pors
    Hypoxia is a well-established characteristic of prostate tumors and is now recognised as a major contributory factor to both tumor progression and increased resistance to therapy. One strategy to target hypoxic tumor cells is the development of hypoxia-activated prodrugs (HAPs), which are... Read more
    This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?
    J Cancer Metastasis Treat 2018;4:11. | doi:10.20517/2394-4722.2017.54
    Published on: 1 Mar 2018  | Viewed:1950  | Downloaded:194
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  • Review|Open Access

    Microenvironment in the pathogenesis of gastric cancer metastasis

    Hiroshi Sawayama, Takatsugu Ishimoto, Hideo Baba
    Tumor tissues contain cancer cells, other cellular and non-cellular components. Tumor microenvironments consist of cancer cells and various types of stromal cells, cancer associated fibroblasts, bone marrow-derived cells, endothelial cells, and hematopoietic cells, mainly tumor-associated... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:10. | doi:10.20517/2394-4722.2017.79
    Published on: 28 Feb 2018  | Viewed:1283  | Downloaded:127
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  • Review|Open Access

    Therapeutic targets against gastric cancer stem cells interacting with tumor microenvironment

    Tomoyuki Uchihara, Takatsugu Ishimoto, Atsuko Yonemura, Hideo Baba
    Gastric cancer (GC) is a major cause of cancer-related deaths worldwide. The existence of cancer stem cells (CSCs) is known to be the main reason for resistance to anticancer agents as well as for the development of distant metastases. Although CSCs themselves harbor self-renewal and... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:9. | doi:10.20517/2394-4722.2017.81
    Published on: 26 Feb 2018  | Viewed:997  | Downloaded:107
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  • Review|Open Access

    Significance of peritoneal lavage cytology based on genetic signatures in gastric cancer

    Tasuku Matsuoka, Masakazu Yashiro
    Peritoneal metastasis is the most common pattern of recurrence and the most frequent cause of death after surgery in patients with gastric cancer. Peritoneal free cancer cells disseminated from the primary lesion site have been considered the main cause of peritoneal metastasis. Peritoneal lavage... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:6. | doi:10.20517/2394-4722.2017.85
    Published on: 9 Feb 2018  | Viewed:1044  | Downloaded:72
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  • Review|Open Access

    Gastric cancer: prevention and treatment of peritoneal metastases

    Paul H. Sugarbaker
    Gastric cancer is an aggressive malignancy that may metastasize through the bloodstream to the liver, through lymphatics to regional lymph nodes, or by penetration of the peritoneal lining of the stomach to result in seeding of the abdominal and pelvis surfaces. Peritoneal metastases are the most... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:7. | doi:10.20517/2394-4722.2017.67
    Published on: 9 Feb 2018  | Viewed:2592  | Downloaded:142
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  • Original Article|Open Access

    Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis

    Filipa Macedo, Kátia Ladeira, Adhemar Longatto-Filho, Sandra F. Martins
    Aim: Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to distant organ metastasis. The systemic chemotherapy has a minimal effect in peritoneal metastasis so new types of treatment have emerged.... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:8. | doi:10.20517/2394-4722.2017.72
    Published on: 9 Feb 2018  | Viewed:1259  | Downloaded:98
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  • Review|Open Access

    Bacteria in cancer therapy: beyond immunostimulation

    Wheeler Torres, Víctor Lameda, Luis Carlos Olivar, Carla Navarro, Jorge Fuenmayor, Adrián Pérez, Andres Mindiola, Milagros Rojas, María Sofía Martínez, Manuel Velasco, Joselyn Rojas, Valmore Bermudez
    Currently, conventional therapies in cancer are improving; chemotherapy, radiotherapy and surgery have increased survival significantly. New therapies have arisen with the same goal; immunotherapy has appeared as a promising option in the fight against cancer stimulating the immune system by... Read more
    J Cancer Metastasis Treat 2018;4:4. | doi:10.20517/2394-4722.2017.49
    Published on: 24 Jan 2018  | Viewed:5630  | Downloaded:453
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  • Case Report|Open Access

    Pancreatic neuroendocrine tumor liver metastasis in a patient with previously diagnosed pancreatic adenocarcinoma: an unexpected diagnosis

    Mário Fontes-Sousa, Helena Magalhães, Bianca Machado, Olga Sousa, Manuela Machado
    Locally advanced pancreatic carcinoma has an usually poor prognosis despite multimodal approaches and sequential chemotherapy. The authors present a case of a long-term survivor with stage III pancreatic adenocarcinoma achieving partial response after a multimodal approach including local and... Read more
    J Cancer Metastasis Treat 2018;4:5. | doi:10.20517/2394-4722.2017.70
    Published on: 24 Jan 2018  | Viewed:1669  | Downloaded:66
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  • Commentary|Open Access

    Immunotherapy of cancer is a part of biotherapy

    Shuen-Kuei Liao, Robert K. Oldham
    This article belongs to the Special Issue Cancer Immunotherapy
    J Cancer Metastasis Treat 2018;4:3. | doi:10.20517/2394-4722.2017.63
    Published on: 22 Jan 2018  | Viewed:993  | Downloaded:141
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  • Review|Open Access

    A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines

    Taku A. Tokuyasu, Jian-Dong Huang
    Cancer immunotherapy has now been conclusively shown to be capable of producing durable responses for a substantial number of patients. Adoptive cell transfer and checkpoint blockade therapies in particular both demonstrate that antigen-specific immune responses can be dramatically effective,... Read more
    This article belongs to the Special Issue Cancer Immunotherapy
    J Cancer Metastasis Treat 2018;4:2. | doi:10.20517/2394-4722.2017.52
    Published on: 18 Jan 2018  | Viewed:4029  | Downloaded:250
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  • Original Article|Open Access

    Impact of previous anti-angiogenesis treatment in nivolumab-treated advanced non-small cell lung cancer

    Takefumi Komiya, Chao H. Huang, Prakash Neupane, Stephen K. Williamson, Prabhakar Chalise
    Aim: To investigate how previous systemic therapy such as anti-angiogenesis can influence cancer immunotherapy for non-small cell lung cancer (NSCLC). Methods: A total of 134 patients with advanced NSCLC who were treated with nivolumab were retrospectively reviewed. Correlation between status of... Read more
    J Cancer Metastasis Treat 2018;4:1. | doi:10.20517/2394-4722.2017.65
    Published on: 17 Jan 2018  | Viewed:1437  | Downloaded:82
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Journal of Cancer Metastasis and Treatment ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)
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