Articles
  • Review|Open Access

    Prostate cancer cells at a therapeutic gunpoint of the autophagy process

    Fabio Gabriele , Carolina Martinelli , Sergio Comincini
    In a normal prostate, the process of controling cell death is essential to maintain tissue homeostasis and its inhibition may lead to the development of cancer. Androgen receptor signaling plays pivotal roles in the prostate development and homeostasis as well as in the progression of prostate... Read more
    This article belongs to the Special Issue Autophagy and Cancer: current biology and drug development
    J Cancer Metastasis Treat 2018;4:17. | doi:10.20517/2394-4722.2018.06
    Published on: 19 Apr 2018  | Viewed:57  | Downloaded:8
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  • Meta-Analysis|Open Access

    The potential prognostic and predictive roles of programmed cell death protein 1 expressed by tumor-infiltrating lymphocytes in solid tumors: a meta-analysis

    Dong-Yun Zhang , Rong-Zhi Liu , Jian-Wei Ku , Yu-Hong Ma , Ying-Jie Yi
    Aim: Several previous studies have evaluated the potential role of programmed cell death protein 1 (PD-1) expressed by tumor-infiltrating lymphocytes (TILs) in various solid tumors and performed its prognosis role in patients’ survival with inconsistent results. This study aims to further... Read more
    J Cancer Metastasis Treat 2018;4:16. | doi:10.20517/2394-4722.2018.01
    Published on: 12 Apr 2018  | Viewed:100  | Downloaded:30
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  • Original Article|Open Access

    Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

    Edgar Salas , Pedro Sanchez , Juan Postigo , Carlos A. Castaneda , Miluska Castillo , Valeria Villegas , Luis Cano , Sandro Casavilca , Luis A. Bernabe , Carolina Belmar , Maria R. Villa-Robles , Raul Mantilla , Henry Guerra
    Aim: Upper alveolar ridge and hard palate squamous cancer is an infrequent malignancy. We evaluated factors associated with neck involvement and with p16-staining. Methods: Head and neck squamous-cell carcinoma (SCC) patients who went to Head and Neck Department between 1997 and 2011 were... Read more
    J Cancer Metastasis Treat 2018;4:15. | doi:10.20517/2394-4722.2017.66
    Published on: 28 Mar 2018  | Viewed:338  | Downloaded:20
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  • Review|Open Access

    The magnitude of benefit from adding taxanes to anthracyclines in the adjuvant settings of breast cancer: discussion of large trials and meta-analyses

    Osama H. Elzaafarany , Atlal Abusanad
    The taxanes family of chemotherapy, which includes paclitaxel and docetaxel, has been incorporated in the adjuvant breast cancer treatments since 1990s. Sequential and concurrent use of taxanes was investigated with anthracyclines in many adjuvant early breast cancer randomized clinical trials.... Read more
    J Cancer Metastasis Treat 2018;4:14. | doi:10.20517/2394-4722.2017.55
    Published on: 15 Mar 2018  | Viewed:439  | Downloaded:29
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  • Commentary|Open Access

    Targeting adenosine receptor 2B in triple negative breast cancer

    Carola A. Neumann , Kevin Levine , Steffi Oesterreich
    J Cancer Metastasis Treat 2018;4:13. | doi:10.20517/2394-4722.2017.60
    Published on: 15 Mar 2018  | Viewed:521  | Downloaded:45
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  • Review|Open Access

    Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives

    Francesca Battaglin , Alberto Puccini , Madiha Naseem , Marta Schirripa , Martin D. Berger , Ryuma Tokunaga , Michelle McSkane , Taline Khoukaz , Shivani Soni , Wu Zhang , Heinz-Josef Lenz
    The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with the introduction of novel targeted agents and new therapeutic strategies for the metastatic disease. An extensive effort has been directed to the identification of predictive biomarkers to aid patients... Read more
    This article belongs to the Special Issue Cancer Pharmacogenomics
    J Cancer Metastasis Treat 2018;4:12. | doi:10.20517/2394-4722.2018.04
    Published on: 7 Mar 2018  | Viewed:830  | Downloaded:92
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  • Review|Open Access

    Current challenges and opportunities in treating hypoxic prostate tumors

    Declan J. McKenna , Rachel Errington , Klaus Pors
    Hypoxia is a well-established characteristic of prostate tumors and is now recognised as a major contributory factor to both tumor progression and increased resistance to therapy. One strategy to target hypoxic tumor cells is the development of hypoxia-activated prodrugs (HAPs), which are... Read more
    This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?
    J Cancer Metastasis Treat 2018;4:11. | doi:10.20517/2394-4722.2017.54
    Published on: 1 Mar 2018  | Viewed:1369  | Downloaded:135
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  • Review|Open Access

    Microenvironment in the pathogenesis of gastric cancer metastasis

    Hiroshi Sawayama , Takatsugu Ishimoto , Hideo Baba
    Tumor tissues contain cancer cells, other cellular and non-cellular components. Tumor microenvironments consist of cancer cells and various types of stromal cells, cancer associated fibroblasts, bone marrow-derived cells, endothelial cells, and hematopoietic cells, mainly tumor-associated... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:10. | doi:10.20517/2394-4722.2017.79
    Published on: 28 Feb 2018  | Viewed:629  | Downloaded:70
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  • Review|Open Access

    Therapeutic targets against gastric cancer stem cells interacting with tumor microenvironment

    Tomoyuki Uchihara , Takatsugu Ishimoto , Atsuko Yonemura , Hideo Baba
    Gastric cancer (GC) is a major cause of cancer-related deaths worldwide. The existence of cancer stem cells (CSCs) is known to be the main reason for resistance to anticancer agents as well as for the development of distant metastases. Although CSCs themselves harbor self-renewal and... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:9. | doi:10.20517/2394-4722.2017.81
    Published on: 26 Feb 2018  | Viewed:663  | Downloaded:78
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  • Review|Open Access

    Significance of peritoneal lavage cytology based on genetic signatures in gastric cancer

    Tasuku Matsuoka , Masakazu Yashiro
    Peritoneal metastasis is the most common pattern of recurrence and the most frequent cause of death after surgery in patients with gastric cancer. Peritoneal free cancer cells disseminated from the primary lesion site have been considered the main cause of peritoneal metastasis. Peritoneal lavage... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:6. | doi:10.20517/2394-4722.2017.85
    Published on: 9 Feb 2018  | Viewed:684  | Downloaded:54
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  • Review|Open Access

    Gastric cancer: prevention and treatment of peritoneal metastases

    Paul H. Sugarbaker
    Gastric cancer is an aggressive malignancy that may metastasize through the bloodstream to the liver, through lymphatics to regional lymph nodes, or by penetration of the peritoneal lining of the stomach to result in seeding of the abdominal and pelvis surfaces. Peritoneal metastases are the most... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:7. | doi:10.20517/2394-4722.2017.67
    Published on: 9 Feb 2018  | Viewed:1349  | Downloaded:96
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  • Original Article|Open Access

    Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy: revising an option for peritoneal carcinomatosis

    Filipa Macedo , Kátia Ladeira , Adhemar Longatto-Filho , Sandra F. Martins
    Aim: Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to distant organ metastasis. The systemic chemotherapy has a minimal effect in peritoneal metastasis so new types of treatment have emerged.... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:8. | doi:10.20517/2394-4722.2017.72
    Published on: 9 Feb 2018  | Viewed:853  | Downloaded:68
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  • Review|Open Access

    Bacteria in cancer therapy: beyond immunostimulation

    Wheeler Torres , Víctor Lameda , Luis Carlos Olivar , Carla Navarro , Jorge Fuenmayor , Adrián Pérez , Andres Mindiola , Milagros Rojas , María Sofía Martínez , Manuel Velasco , Joselyn Rojas , Valmore Bermudez
    Currently, conventional therapies in cancer are improving; chemotherapy, radiotherapy and surgery have increased survival significantly. New therapies have arisen with the same goal; immunotherapy has appeared as a promising option in the fight against cancer stimulating the immune system by... Read more
    J Cancer Metastasis Treat 2018;4:4. | doi:10.20517/2394-4722.2017.49
    Published on: 24 Jan 2018  | Viewed:3696  | Downloaded:336
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  • Case Report|Open Access

    Pancreatic neuroendocrine tumor liver metastasis in a patient with previously diagnosed pancreatic adenocarcinoma: an unexpected diagnosis

    Mário Fontes-Sousa , Helena Magalhães , Bianca Machado , Olga Sousa , Manuela Machado
    Locally advanced pancreatic carcinoma has an usually poor prognosis despite multimodal approaches and sequential chemotherapy. The authors present a case of a long-term survivor with stage III pancreatic adenocarcinoma achieving partial response after a multimodal approach including local and... Read more
    J Cancer Metastasis Treat 2018;4:5. | doi:10.20517/2394-4722.2017.70
    Published on: 24 Jan 2018  | Viewed:1145  | Downloaded:51
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  • Commentary|Open Access

    Immunotherapy of cancer is a part of biotherapy

    Shuen-Kuei Liao , Robert K. Oldham
    This article belongs to the Special Issue Cancer Immunotherapy
    J Cancer Metastasis Treat 2018;4:3. | doi:10.20517/2394-4722.2017.63
    Published on: 22 Jan 2018  | Viewed:761  | Downloaded:102
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  • Review|Open Access

    A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines

    Taku A. Tokuyasu , Jian-Dong Huang
    Cancer immunotherapy has now been conclusively shown to be capable of producing durable responses for a substantial number of patients. Adoptive cell transfer and checkpoint blockade therapies in particular both demonstrate that antigen-specific immune responses can be dramatically effective,... Read more
    This article belongs to the Special Issue Cancer Immunotherapy
    J Cancer Metastasis Treat 2018;4:2. | doi:10.20517/2394-4722.2017.52
    Published on: 18 Jan 2018  | Viewed:2665  | Downloaded:177
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  • Original Article|Open Access

    Impact of previous anti-angiogenesis treatment in nivolumab-treated advanced non-small cell lung cancer

    Takefumi Komiya , Chao H. Huang , Prakash Neupane , Stephen K. Williamson , Prabhakar Chalise
    Aim: To investigate how previous systemic therapy such as anti-angiogenesis can influence cancer immunotherapy for non-small cell lung cancer (NSCLC). Methods: A total of 134 patients with advanced NSCLC who were treated with nivolumab were retrospectively reviewed. Correlation between status of... Read more
    J Cancer Metastasis Treat 2018;4:1. | doi:10.20517/2394-4722.2017.65
    Published on: 17 Jan 2018  | Viewed:1130  | Downloaded:62
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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