Topic: Colorectal Cancer Progression and Treatment

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A special issue of Journal of Cancer Metastasis and Treatment  (Print ISSN:2394-4722; Online ISSN:2454-2857).

Deadline for manuscript submissions: 31 Jul 2018

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Guest Editor(s)

  • Prof. Guofeng Xie, MD, PhD
    Department of Medicine, Division of Gastroenterology & Hepatology and Program in Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

    Website | E-mail

Special Issue Introduction:

Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Although curative treatment options for advanced disease are still lacking, rapid progress has been made in the last decade in understanding the molecular mechanisms underlying CRC tumorigenesis and progression. Also, robust preventive measures and novel therapies resulted in decreased CRC incidence and improved survival. Reviews in this special issue will allow readers to gain insights into the current states of CRC prevention, detection, treatment and its unique molecular mechanisms.


Epidemiology; molecular mechanisms underlying CRC tumorigenesis, invasion and metastasis; role of genetic and epigenetic modifications; role of microRNAs; role of diet, intestinal microbiota and immune system; animal and enteroid models; tumor markers in CRC; CRC prevention, detection and therapy

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 31 Jul 2018
Contacts: Lijun Jin, Managing Editor,

Published Articles Download All Articles
  • Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression

    Jessica Felton , Kunrong Cheng , Aaron C. Shang , Shien Hu , Shannon M. Larabee , Cinthia B. Drachenberg , Jean-Pierre Raufman
    Aim: Strong evidence reveals important differences between cancers in the proximal vs. distal colon. Animal models of metastatic colon cancer are available but with varying degrees of reproducibility and several important limitations. We explored whether there were regional differences in the location of murine colon cancers and assessed the utility of murine models to explore the biological... Read more
    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment
    J Cancer Metastasis Treat 2018;4:51. | doi:10.20517/2394-4722.2018.39
    Published on: 27 Sep 2018  | Viewed:193  | Downloaded:11
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  • Immunotherapy in the treatment of colorectal cancer: a new kid on the block

    Andrea Spallanzani , Fabio Gelsomino , Francesco Caputo , Chiara Santini , Kalliopi Andrikou , Giulia Orsi , Margherita Rimini , Stefania Pipitone , Laura Riggi , Camilla Bardasi , Massimiliano Salati , Stefano Cascinu
    In the last few years, the success of anti-PD1 and anti-PDL1 drugs in solid cancers treatment and the advances in molecular biology have provided new potential treatment strategies for patients with metastatic colorectal cancer. Unfortunately, only patients with mismatch repair deficiency seem to benefit from immunotherapy and they represent a small subset of the metastatic population. New... Read more
    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment
    J Cancer Metastasis Treat 2018;4:28. | doi:10.20517/2394-4722.2018.31
    Published on: 19 Jun 2018  | Viewed:1861  | Downloaded:251
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Journal of Cancer Metastasis and Treatment ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)
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