Topic: Breast Cancer Metastasis

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A special issue of Journal of Cancer Metastasis and Treatment  (Print ISSN:2394-4722; Online ISSN:2454-2857).

Deadline for manuscript submissions: 30 Nov 2018

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Guest Editor(s)

  • Prof. William Schiemann
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.

    Website | E-mail

Special Issue Introduction:

Although metastasis is the most lethal characteristic of breast cancer, our understanding of the molecular mechanisms that govern this event remains incomplete. The metastatic cascade is a highly complex and inefficient process this is subject to regulation by a host of intrinsic and extrinsic cellular mechanisms. The rapid development of powerful new technologies and models to study the breast cancer metastasis has greatly expanded our appreciation of the complexities associated with this last frontier of cancer biology. The Journal of Cancer Metastasis and Treatment will produce a Special Issue focused on breast cancer metastasis and its treatment. Included amongst the topics within the scope of this Special Issue on Breast Cancer Metastasis are:

• Mechanisms of EMT programs and cellular plasticity, including breast cancer stem cells
• Mechanisms of metastatic dormancy
• Mechanisms of pro-survival and anti-apoptotic and/stress signals
• Role of noncoding RNA and epigenetics in driving metastatic progression
• Impact of the tumor microenvironment and metastatic niche, including tumor associated fibroblasts, macrophages, and mesenchymal stem cells
• Role of the immune system and immune modulators
• Novel technologies and models to detect and study breast cancer metastases
• Therapeutic targeting of breast cancer metastasis

Questions related to this Special Issue should be directed to the Issue Editor, Dr. William Schiemann ( Submissions will be accepted starting from 20th of July for publication of the Special Issue in Winter 2018/Spring 2019.

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 30 Nov 2018
Contacts: Alice Qian, Assistant Editor,

Published Articles Download All Articles
  • Tumor cell invasion from the marginal sinus into extranodal veins during early-stage lymph node metastasis can be a starting point for hematogenous metastasis

    Tetsuya Kodama , Shiro Mori , Masato Nose
    Aim: To investigate whether tumor cells in a lymph node (LN) can invade from the marginal sinus into extranodal veins via vessel branches that communicate with intranodal veins and whether this can be a starting point for hematogenous metastasis at the early stage of LN metastasis. Methods: Vascular and lymphatic networks of LNs in MXH10/Mo-lpr/lpr mice were investigated using three-dimensional... Read more
    This article belongs to the Special Issue Breast Cancer Metastasis
    J Cancer Metastasis Treat 2018;4:56. | doi:10.20517/2394-4722.2018.61
    Published on: 9 Nov 2018  | Viewed:285  | Downloaded:21
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  • Circulating tumor cells and the metastatic process: the complexity of malignancy

    Tania Di Raimo , Elena De Santis , Luigi Coppola , Mario Rosario D’Andrea , Francesco Angelini
    Despite improvements achieved in terms of early detection and therapeutic approach, metastatic breast cancer remains one of the principal worldwide causes of death. In recent years, due to the heterogeneous response of each patient to chemotherapy, clinical research highlights the need of a personalized approach. Circulating tumor cells (CTCs) represents a promising tool for this purpose.... Read more
    This article belongs to the Special Issue Breast Cancer Metastasis
    J Cancer Metastasis Treat 2018;4:54. | doi:10.20517/2394-4722.2018.50
    Published on: 25 Oct 2018  | Viewed:608  | Downloaded:79
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Journal of Cancer Metastasis and Treatment ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)
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