Topic: Cancer Stem Cells: Impact on Treatment

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A special issue of Journal of Cancer Metastasis and Treatment  (Print ISSN:2394-4722; Online ISSN:2454-2857).

Deadline for manuscript submissions: 17 Jun 2016

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Guest Editor(s)

  • Ira-Ida Skvortsova, MD, PhD
    Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, 6020 Innsbruck, Austria.

    Website | E-mail

Special Issue Introduction:

It is generally believed that the small population of the intratumoral carcinoma stem cells (CSCs) is responsible for poor clinical outcome, because CSCs are considered as a reason for the tumor heterogeneity, diminished sensitivity to chemo- and radiotherapy and enhanced abilities for metastatic spread. Investigation of the biological properties of CSCs is a hot topic in cancer research. In order to know more about CSC behavior, it is necessary to possess the CSC-specific molecular patterns distinguishing CSCs from non-CSCs.

Keywords:

Cancer stem cells, treatment resistance, intracellular signaling, CSC markers, CSC phenotype

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://jcmtjournal.com/pages/view/author_instructions
For Online Submission, please login at https://mc03.manuscriptcentral.com/jcmt
Submission Deadline: 17 Jun 2016
Contacts: Dandan Yu, Managing Editor, dandanyu@oaepublish.com

Published Articles Download All Articles
  • The quintessential quiescence of cancer stem cells: a struggle towards better treatment

    Anuradha Vaidya
    J Cancer Metastasis Treat 2016;2:243-4. | doi:10.20517/2394-4722.2016.10
    Published on: 8 Jul 2016  | Viewed:719  | Downloaded:144
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  • Curcumin sensitizes quiescent leukemic cells to antimitotic drug 5-fluorouracil by inducing proliferative responses in them

    Anagha Gardane , Mariyah Poonawala , Anuradha Vaidya
    Long-term quiescence or dormancy is a fundamental feature of cancer stem cells (CSCs) that are genetically identical to the malignant clone but constitute the only cells with tumor propagation potential within the overall tumor population. These quiescent cells show significant resistance to radiation and antiproliferative chemotherapy due to distinctive properties that seem to be related to their stem cell-like character. Hence, successful anticancer therapy must consist of approaches that can target not only the differentiated cancer cells, but also the CSCs. Using serum-starved KG1a cell... Read more
    J Cancer Metastasis Treat 2016;2:245-52. | doi:10.20517/2394-4722.2016.11
    Published on: 8 Jul 2016  | Viewed:2390  | Downloaded:206
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  • Therapeutic strategies for targeting cancer stem cells

    Yu Jeong Kim , Elizabeth L. Siegler , Natnaree Siriwon , Pin Wang
    The therapeutic limitations of conventional chemotherapeutic drugs present a challenge for cancer therapy; these shortcomings are largely attributed to the ability of cancer cells to repopulate and metastasize after initial therapies. Compelling evidence suggests that cancer stem cells (CSCs) have a crucial impact in current shortcomings of cancer therapy because they are largely responsible for tumor initiation, relapse, metastasis, and chemo-resistance. Thus, a better understanding of the properties and mechanisms underlying CSC resistance to treatments is necessary to improve patient... Read more
    J Cancer Metastasis Treat 2016;2:233-42. | doi:10.20517/2394-4722.2016.26
    Published on: 8 Jul 2016  | Viewed:11411  | Downloaded:1044
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  • Introduction to the Special Issue “Cancer Stem Cells: Impact on Treatment”

    Ira-Ida Skvortsova
    J Cancer Metastasis Treat 2016;2:231-2. | doi:10.20517/2394-4722.2016.35
    Published on: 8 Jul 2016  | Viewed:900  | Downloaded:166
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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