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J Cancer Metastasis Treat 2017;3:60-4. 10.20517/2394-4722.2017.04 © 2017 OAE Publishing Inc.
Open Access Original Article

Percutaneous, computed tomography guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients

1Department of Anaesthesiology and Pain Management, American Medical Center, Strovolos 2054, Nicosia, Cyprus.

2Department of Interventional Radiology, Apollonion Private Hospital, Strovolos 2054, Nicosia, Cyprus.

32nd Radiology Department, University General Hospital “ATTIKON”, 12462 Athens, Greece.

Correspondence Address: Prof. Dimitrios Filippiadis, 2nd Radiology Department, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 1 Rimini Str., 12462 Athens, Greece. E-mail:

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    Aim: This study evaluates the efficacy and safety of percutaneous computed tomography (CT)-guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients.

    Methods: Over the course of 16 months, 22 patients underwent radiofrequency neurolysis as palliative therapy for pain reduction in celiac and splachnic plexus (n = 9), thoracic (n = 1), lumbar (n = 2) and superior hypogastric plexus (n = 5), as well as stellate ganglion (n = 5). Pain levels before treatment, one week after treatment, and at the last follow-up (average follow-up 6 months) were compared by means of a Numeric Visual Scale (NVS) questionnaire and a Brief Pain Inventory (Short Form) questionnaire.

    Results: Median procedure time was 44 min. Median number of CT scans, performed to control correct positioning of the cannula and precise electrode placement, was 8. Pain scores of questionnaires prior to treatment (mean value 9.50 NVS units, range 8-10 NVS units) and post treatment (mean value 3.27 NVS units, range 2-6 NVS units) showed a mean decrease of 6.23 NVS units in terms of pain reduction and life quality improvement (P < 0.05). Overall mobility improved in 18/18 (100%) patients. No complication was observed.

    Conclusion: This study concludes that CT-guided neurolysis by means of continuous radiofrequency ablation is a safe and efficient technique for pain palliation in oncologic patients.


    Approximately half of cancer patients report pain at the time of diagnosis, and nearly 80% of advanced stage cancer patients report moderate to severe pain.[1] Cancer pain can be classified as nociceptive (caused by ongoing tissue damage) or neuropathic (caused by damage or dysfunction in the nervous system), or mixed pain.[2,3] The World Health Organization (WHO) analgesic ladder was introduced in 1986 as a simplified model of analgesics escalation.[4] The three-step analgesic ladder proposed by WHO provides satisfactory pain management in a significant proportion of cancer patients. However, nearly one third of oncologic patients complain of refractory (nonresponsive) pain.[5] Despite its value, opioid administration can be costly; additionally, dose and continuous use relate directly to risk of harm.[6,7] Recently, a fourth step was proposed for refractory pain, which includes minimally invasive percutaneous techniques.

    Radiofrequency ablation has been used since the 1970s for chronic pain therapy in cases of refractory pain. Ablation with continuous radiofrequency results in high temperatures (60-80 °C) that promote neurolysis and destroy the target nerves.[8,9] In contrast, application of pulsed radiofrequency maintains the temperature below 42 °C, promoting neuromodulation of the target nerves.[10,11] Both continuous and pulsed radiofrequency modes have been applied for pain reduction in symptomatic cancer patients with refractory pain. Percutaneous neurolysis can be either chemical (phenol or alcohol injection) or thermal (radiofrequency or cryoablation). During continuous radiofrequency (RF) ablation an electrode is placed close to a nerve fiber, applying energy which is transformed to high temperature causing protein denaturation and destruction of the axons, resulting in transmission blockage of nociceptive signals from the periphery.[12]

    The purpose of this study is to evaluate efficacy and safety of percutaneous computed tomography (CT)-guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients with pain refractory to standard treatments proposed in the WHO three-step analgesic ladder.


    All patients were informed about the technique itself as well as about possible benefits and complications. All patients signed a written consent form for the procedure. Authors have no conflict of interest to declare. No industry support was received for this study.

    Patient selection

    This is a retrospective study evaluating a consecutive series of patients undergoing CT-guided neurolysis using continuous radiofrequency ablation. During the last 16 months, 22 patients (10 males/12 females) suffering from cancer pain refractory to systemic therapy with opioids and adjuvant drugs were referred for percutaneous CT-guided neurolysis as palliative therapy for pain reduction. All patients treated had no contraindications for regional blockade. Malignant background included pancreatic carcinoma (n = 8), pancoast tumor (n = 5), lymphoma (n = 1), renal cell (n = 1), endometrial (n = 2), colon (n = 2) and ovarian (n = 3) carcinoma. Patients underwent neurolysis by means of radiofrequency (Diros Technology In, Ontario Canada) in celiac and splanchnic plexus (n = 9), in thoracic (n = 1), in lumbar (n = 2), in superior hypogastric plexus (n = 5) and in stellate ganglion (n = 5) [Figure 1].

    Figure 1. Cannullae are percutaneously placed in the desired location, most commonly under computed tomography guidance. Coaxially 10 mm active tip radiofrequency electrodes are inserted and connected to the generator. Motor and sensory tests are performed prior to the neurolysis session


    All procedures were performed in the CT room, under anesthetic monitoring and strict aseptic technique by two interventional radiologists with cooperation of an anesthesiologist. Unilateral or bilateral approach was used, depending on the blockage that was performed. The procedural route and site of the skin puncture were determined with CT guidance. Once the puncture site was located, local anesthetic (5-10 mL of Lidocaine Hydrochloric 2%) was injected into the subcutaneous soft tissue. Under continuous CT scans at the level of interest, 20 G trocar(s) was (were) percutaneously inserted and advanced. The final trocar position was verified with CT scan post contrast medium injection.

    For the celiac plexus neurolysis, a posterior transcrural approach was used, with needles passing through the diaphragmatic crura in route to the celiac plexus anterolateral to the aorta. For the neurolysis of the splanchnic nerves, a retrocrural approach was performed with the needles remaining posterior to the diaphragmatic crura and placed at the level of L1 vertebral body (cephalad half) and at midportion of T12 vertebral body. For the lumbar plexus neurolysis, two or three needles were placed over the transverse process of L2, L3 and L4 vertebrae, respectively, with the needle tip at the anteromedial vertebral body surface where the lumbar sympathetic block lies. For the superior hypogastric neurolysis, the needle was placed at the anterolateral surface of L5-S1 intervertebral disc, either via posterolateral access through the sacral ala and the superior articular process of S1 or via transdiscal access. Thoracic neurolysis was performed with the needles placed at the space between vertebral body (lateral aspect) and pleura at T2 and T3 levels.

    Coaxially, the RF electrode was then inserted [Figures 2-4]. Motor and sensory tests were performed to verify the electrode’s correct position near the sensory nerve segment and away from the motor root. Upon satisfactory test results, two CRF ablation sessions were performed at 80 °C, with total duration time of 90 s each. All patients were closely observed postoperatively for pain, sensory and motor deficits, as well as for vital signs. Patients remained in the hospital overnight for hydration and observation and exited the morning after the procedure.

    Figure 2. Stellate ganglion neurolysis: the ganglion is usually located lateral to the outer border of longus colli muscle anterior to the neck of the first rib and the transverse process of the 7th cervical vertebra

    Figure 3. Splachnic neurolysis is a modification of the classic retrocrural approach for celiac plexus. Needles are placed at the midportion of T12 vertebral body

    Figure 4. Neurolysis of lumbar sympathetic chain: three needles are placed over the anterolateral surface of L2, L3 and L4 vertebral bodies

    Outcome measures

    Pain assessment was performed using the Numeric Rating Scale (NRS, 0-10) questionnaire and Brief Pain Inventory (Short Form) questionnaire for reviewing quality of life.[19] The questionnaires were recorded before the treatment, one week after treatment, and at the last follow-up (average follow-up 6 months).


    Twenty-two patients were studied, all suffering from cancer pain refractory to systemic therapy with opioids and adjuvant drugs. All patients completed the follow-up of six months.

    Median procedure time was 44 min. Median number of CT scans, performed to control correct positioning of the cannula and precise electrode placement, was 8. No complications occurred during the procedure, and all patients tolerated the procedure well.

    Comparing the self-reported pain scores of questionnaires prior to treatment (mean value 9.50 NRS units, range 8-10 NRS units) and at 6 months post treatment (mean value 3.27 NRS units range 2-6 NRS units), there was a mean decrease of 6.23 NRS units in terms of pain reduction and life quality improvement [Figure 5]. Overall mobility improved in 18/18 (100%) patients.

    Figure 5. Chart illustrating mean pain scores and pain reduction prior to and after the neurolysis session. NVS: numeric visual scale


    Cancer pain has direct implications for patients’ quality of life. Cancer pain can be classified as nociceptive (described as somatic or visceral and caused by ongoing tissue damage) or neuropathic (caused by damage or dysfunction in the nervous system).[2,3] The WHO analgesic ladder has three steps for acute pain, chronic pain without control, or acute crises of chronic pain. In step 1, nonopioids, analgesics, and NSAIDs are administered to the patient. In step 2, weak opioids can be added to the treatment regime. In step 3, methadone or strong opioids can be administered orally or by means of a transdermal patch.

    Unfortunately, conservative therapy does not adequately reduce pain in the vast majority of oncologic patients (56% to 82.3%).[2,3] On the other hand, numerous studies in the literature report significant pain reduction post chemical or thermal neurolysis.[13-16] Papadopoulos et al.,[17] who conducted treatment with radiofrequency ablation of splanchnic nerves on 35 patients with end-stage pancreatic abdominal cancer pain refractory to conservative treatment, reported significant decrease in pain scores and consumption of opioids and significant improvement in the patient quality of life during a follow-up period of 6 months.

    Our study included patients with a diversity of malignant substrate, evaluating the efficacy of RF neurolysis in celiac and splanchnic plexus (n = 9), in the thorax (n = 1), in the lumbar region (n = 2), in superior hypogastric plexus (n = 5), and in the stellate ganglion (n = 5). The results of our study (statistically significant mean decrease of 6.23 NVS units on terms of pain reduction and life quality improvement) are in agreement with the previously mentioned success rates.

    Percutaneous neurolysis has been reported as a safe procedure with a low complications rate. The most commonly reported complications include transient diarrhea (10-25%), orthostatic hypotension (20-42%), and local pain. Rarer complications include paresis, pneumothorax, shoulder pain (1%), hemorrhagic gastritis, duodenitis, and death.[18-20] In our study we performed continuous RF neurolysis in all our patients, and we did not experience any complications. We believe that continuous RF neurolysis has a shorter risk-benefit ratio than alcohol neurolysis, since it is a more sophisticated and targeted interventional technique. When compared to medical management by opioids, percutaneous neurolysisis superior in terms of fewer burdensome side effects.[5,21,22]

    Correct cannula positioning should always be verified with electrical stimulation prior to ablation. Two stimulation types are performed: sensory and motor. Successful electrical sensory stimulation triggers pain that aligns with the patient’s usual distribution of pain. When motor stimulus is performed, there should be no motor response in a threshold below 2.0 volts or below twice the threshold value of the sensory test. Sensory testing increases the technique’s efficacy, and motor stimulation ensures safety from motor impairment.

    Limitations of our study include its retrospective nature as well as the diversity of the malignant substrate. Additionally, there was no randomized comparison between continuous RF neurolysis and placebo therapy, chemical neurolysis with phenol or alcohol, or medical management.

    Radiofrequency neurolysis under CT guidance is feasible and reproducible, efficient (70-80% success rate), and safe (> 0.5% mean complications rate) as palliative therapy for pain reduction in oncologic patients with refractory pain. Thorough knowledge of nervous system anatomy and pain transmission pathways is essential for proper patient and technique selection.

    Authors’ contributions

    Text writing: P. Zavridis, A. Mazioti

    Statistic analysis: M. Tsitskari

    Submission editing: D. Filippiadis

    Financial support and sponsorship


    Conflicts of interest

    There are no conflicts of interests.

    Patient consent

    Patient consent was obtained.

    Ethics approval

    Ethics approval was obtained.


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    Cite This Article

    Zavridis P, Tsitskari M, Mazioti A, Filippiadis D. Percutaneous, computed tomography guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients. J Cancer Metastasis Treat 2017;3:60-4.



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