fig1

Figure 1. Extramedullary infiltration formation process in acute myeloid leukemia. (a) Within deregulation of LSCs located in BM, cell links with niche will be cut, and then they will enter into the circulation via BM sinusoids; (b) disseminated LSCs circulate in blood vessels and based on their special characteristics, enter specific tissue, like skin; (c) leukemic cells, along with new, distinct niche, initiate new tumor in metastatic tissue. The exact molecular and cellular characteristics have not been defined completely. SDF-1: stromal cell-derived factor 1; BM: bone marrow; LSC: leukemic stem cells; HSC: hematopoietic stem cell; CAR cell: CXCL12-abundant reticular cell