fig1

Figure 1. Natural history of prostate cancer progression in patients' population from a Swedish watchful waiting cohort with up to 30 years follow-up (A) and classification performance of the 98 genes signature of lethal disease in prostate cancer patients (B-E). (A) Cancer-specific survival data in the entire watchful waiting cohort are presented to illustrate markedly distinct survival timelines of non-treated prostate cancer patients diagnosed with different Gleason scores prostate cancer. Kaplan-Meier survival analysis of the classification performance of the 98 genes GES in the training set (B), test set (C), and pooled cohort of 281 patients (D, E). Classification threshold 98 genes GES score of 270.43 units was chosen using the training set of 141 prostate cancer patients and consistently applied in all subsequent validation screens using the Kaplan-Meier survival analysis to stratify the patients into lethal disease sub-groups (score ≥ 270.43) and moderate/aggressive disease sub-group (score < 270.43). Percent value indicates the proportion of patients in the lethal disease sub-group. P values indicate the significance of the differences in the numbers of death events and surviving patients between the groups which was determined using two-sided Fisher's exact test. GES: gene expression signatures