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Figure 3. GES-based identification of lethal disease in prostate cancer patients with different age at diagnosis. Kaplan-Meier survival analysis of the classification performance of the 98 genes GES in 34 prostate cancer patients of age 65 or younger (A), 64 prostate cancer patients of age 70 or younger (B). Bottom figures in both A and B panels show the results of Kaplan-Meier survival analysis for Gleason 6 and 7 patients only of corresponding age groups. Classification threshold 98 genes GES score of 270.43 units was chosen using the training set of 141 prostate cancer patients and consistently applied in all subsequent validation screens using the Kaplan-Meier survival analysis to stratify the patients into lethal disease sub-groups (score ≥ 270.43) and moderate/aggressive disease sub-group (score < 270.43). Percent values indicate the proportion of patients in the lethal disease sub-group. P values indicate the significance of the differences in the numbers of death events and surviving patients between the groups which was determined using two-sided Fisher's exact test. GES: gene expression signatures