fig14

Figure 14. Crystal structure of Trp741Leu AR-LBD in complex with R-bicalutamide (PDB ID 4OJB). Carbon atoms of R-bicalutamide are coloured in blue, the AR is grey. Nitrogen, oxygen, sulphur, atoms are depicted in blue, red and yellow respectively. Relevant water molecules are represented by red points. AR: androgen receptor; LBD: ligand-binding domain