fig3

Figure 3. Structures of (A) CYP17A1 in complex with abiraterone (PDB ID 3RUK) and (B) CYP17A1 mutant A105L with substrate pregnenolone (PDB ID 4NKW). Abiraterone is depicted in green, pregnenolone in pink. Carbon atoms of the protein are depicted in grey, the haeme prosthetic group is coloured in blue. Nitrogen, oxygen and sulphur atoms are depicted in blue, red and yellow, respectively. Relevant water molecules are represented by red points