fig1

Figure 1. Immunosurveillance vs. immunoediting: key points in regulation of immune system in tumor progression/regression. Immunoediting comprises 3 phases: (A) elimination: when the tumorcells begins to proliferate, an inflammatory response is induced by the injured tissue. This causes the migration of cells from the immune system, orchestrating the innate immune response; (B) the equilibrium phase: in which this continuous process produces a selective pressure in these cells that can cause genetic or epigenetic rearrangement, causing certain cells to evade these immunological effector mechanisms; (C) the escape phase, when cells that have evaded these mechanisms also gained uncontrolled growth ability. DC: dendritic cells; MHC: major histocompatibility complex; NK: natural killers