fig1

Figure 1. A simplified schematic of reciprocal tumor-host interactions. Tumors promote aberrant physiology via alterations to the immune system and secretion of metabolic “waste” which contributes to further inflammation and altered function of distal organs, including the brain. Feedback from the brain (neural or humoral) can subsequently exacerbate tumor-associated immune and metabolic changes, ultimately facilitating tumor growth, angiogenesis, metastasis, or cancer-associated co-morbidities