fig2

Figure 2. Lysine specific demethylase 1 (LSD1) regulates cell motility and epithelial to mesenchymal transition (EMT). A: Snail is stabilized through the formation of a ternary Snail1-LSD1-CoREST complex. SNAG domain of Snail binds LSD1 and recruits it together with CoREST to E-boxes of Snail target gene promoters. LSD1 binds the histones H3 tail and removes the activation marks on H3K4. HDAC1 and 2 deacetylate histones 3 and 4 (H3/H4), subsequently PRC2 directs the trimethylation of H3K27; B: H3K9 demethylation activity by LSD1 in complex with ERRα leads to transcriptional activation of pro-invasive genes; C: LSD1 inhibits EMT process through binding to NuRD impairing TGF-β signaling genes expression. D LSD1 with UTX functions as epigenetic silencer of EMT TFs