fig3

Figure 3. Lysine specific demethylase 1 (LSD1) is differently modified at post-translation level in epithelial and mesenchymal cells. A: In epithelial cells, MOF acetylates LSD1, and this modification induces the dissociation of LSD1/SNA1 complex. Then, LSD1 cannot block CDH1 transcription; B: in mesenchymal cells, PKCα phosphorylates LSD1. LSD1 phosphorylated interacts with SNA1 in order to silence CDH1 gene