fig4

Figure 4. Strategy for the isolation of extracellular vesicles (EVs) derived from SCLC cells. SCLC-specific EVs are enriched and purified by RNL-1 and/or 123C antibodies, specific for the extracellular moiety of NCAM^[19-21], coupled to magnetic beads. In the next step the presence of E18 in the EVs will be measured with one of the specific antibodies. We will choose the antibody with the best signal to noise ratio