fig1

Figure 1. CXCL12-induced signalling via CXCR4 and CXCR7. (A) CXCL12 binds to CXCR4, inducing Gα and Gβγ dissociation and activation of PI3K, MAPK, AC, and PLC signalling pathways. CXCL12 binding to CXCR4 activates β-Arrestin, leading to MAPK signalling pathway activation or receptor internalization. (B) CXCR4 can form homo- and hetero-dimers with CXCR7. (C) CXCL12 binding to CXCR7 induces, via β-Arrestin, MAPK signalling activation, or CXCL12 scavenging, through receptor internalisation and recycling to the plasma membrane. CXCL12-mediated signalling plays a role in cell chemotaxis, migration, proliferation and survival. PI3K: phosphatidylinositide 3-kinase; MAPK: mitogen-activated protein kinases; AC: adenyly cyclase; PLC: phospholipase C