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Figure 4. The role of PAK4 in cell signaling: external signals initiate the activation of small GTPases Cdc42 and Rac, which in turn bind to and activate PAK4. PAK4 has roles in cytoskeletal organization, motility, adhesion, and the regulation of gene expression. mRNA and protein levels of PAK4 are often seen to be overexpressed in several types of cancer, such as breast cancer and pancreatic cancer. GBD: GTPase binding domain