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Figure 1. Clinical presentation and course of breast neoplastic lesion during chemo-immunotherapy with cyclophosphamide, fluorouracil and interleukin-2. A: (November 2018): presence of polylobed and ulcerated neoplastic mass of 7 cm × 7 cm and overlying vegetative lesion of 4 cm located on the right breast; B: (December 2018): 2 weeks, after chemo-immunotherapy reduction in size and consistency of the neoplastic mass of 5 cm × 7 cm and of polylobed overlying vegetative lesion of 3 cm located in the right breast; C: (December 2018): 5 weeks after chemo-immunotherapy, further reduction in size and thickness of nodules in the right breast; D: (January 2019): increase in size of the polylobed and ulcerated neoplastic mass of 8 cm × 8 cm with nodules above greater than 4.5 cm located in the right breast after chemo-immunotherapy