fig6

Figure 6. Representative example of chromothripsis: CMA plot of chromosome 12 demonstrating 14 alternating CNAs involving the proximal region of the short (p) and long (q) arms of chromosome 12. This pattern of alternating CNAs is suggestive of “chromothripsis”. In addition, there is a deletion of the remaining distal portion of 12p. Sample was tested using the Agilent 180k aCGH+SNP oligo array, and data analysis was performed using the Agilent CytoGenomics software v4.0 (Image courtesy of Dr. Fady M. Mikhail, MD PHD, University of Alabama at Birmingham). CMA: chromosomal microarray; CNAs: copy number abnormalities