fig4

Figure 4. Schematics of the ATM-p53-Tip60-MDM2-HIPK2-RANBP9 potential connection in NSCLC cells subject to genotoxic stress. RANBP9 appears to be at the center of an intricate network determining cell fate during DDR. Green double lines with question marks indicate active areas of investigation. RANBP9: RAN binding protein 9; ATM: ataxia telangiectasia mutated; NSCLC: non-small cell lung cancer; HIPK2: homeodomain-interacting protein kinase 2