fig3

Figure 3. Schematic presentation of PCSC properties and their contribution to EMT, tumor metastasis and recurrence, chemoresistance, and apoptosis resistance. Potential CSC markers and signaling pathways in PCSCs and activation of several signaling pathways in the self-renewal, maintenance, and tumor recurrence in PDAC are also shown. PCSC: pancreatic cancer stem cell; EMT: epithelial-mesenchymal transition