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Figure 3. Current clinical studies evaluating the use of exRNA and exosomes as cancer biomarkers. An advanced search for query terms (“extracellular RNA” OR exosome OR exRNA OR oncosome) AND biomarker focused on cancer as a disease model, was performed on ClinicalTrials.gov on 11 May 2020. The search was restricted to recruitment statuses on recruiting, not yet recruiting, active, not recruiting, completed, enrolling by invitation, and studies of unknown status. The search returned 45 studies which are summarized in Figures 3A-C. A: A world map shows the locations (in red) of all clinical studies evaluating the use of exRNA and exosomes as cancer biomarkers. The numbers indicate the clinical studies in each location; B: clinical trials were grouped by general cancer type and the number of studies focused on each cancer type are shown. Projects that did not specify cancer type were grouped together as non-specific cancer; C: the clinical trial data was parsed for the types of biofluids used in each study. Some studies examined multiple types of biofluids while other did not include biofluid sampling. The table represents biofluids examined in all 45 clinical studies