fig1
From: Role of autophagic response induced by major phytochemicals in cancer prevention and treatment
Figure 1. Schematic diagram representing the mechanism by which phytochemicals inhibit PI3k/mTOR pathway to induce autophagy. Induction of autophagy ensues upon negative regulation of mTOR that leads to formation of a phagophore and subsequent sequestration of cellular constituents in the presence of important autophagy proteins (Atg proteins) and cleaved LC3-II. Fusion of the autophagosome with lysosome results in lysis and generation of energy that is typically expended for cell survival or cell death (Type II). mTOR: mammalian target of rapamycin
