fig1

Figure 1. EZH2 is a histone methyltransferase, catalysing the transfer of donor methyl groups from SAM to H3K27 via its C-terminal SET domain. EZH2 predominantly functions as part of a multi-protein complex, PRC2, containing the core units SUZ12, EED, and RbBP4, which aid in recognition and targeting of EZH2 activity to histone 3 lysine-27. A number of other auxiliary proteins are known to complex with PRC2 but are disposable to its core activity. All structures are representative only. Subset of images from Servier medical art https://smart.servier.com/?s=nucleosome. SAM: S-adenosyl-L-methione.