fig2
Figure 2. Ovariectomy stimulates metastatic outgrowth of E0771 mammary cancer cells disseminated in bones of syngeneic C57BL/6 mice. Injection of 2 × 105 E0771 cells into the fourth mammary duct of 12-week-old female C57BL/6 mice resulted in tumour growth at the primary site and dissemination of tumour cells into the skeleton (A). Five weeks following ovariectomy, disseminated tumour cells in bone were activated to induce overt metastases. These metastatic outgrowths can be observed in the ling bones and lungs (B). Data shown are previously unpublished observations from the Ottewell laboratory.
