fig1

Figure 1. Local cancer fields for carcinoma of the uterine cervix determined by development. (A) Lineage specification pathway of cervical epithelial and stromal cells from nephrogenic cord precursor cells. (B) Ontogenetic anatomy of the uterine cervix displayed in a midpelvic transverse section as indicated by the sagittal inset. Mature tissue derivatives from the morphogenetic units of the three generations of precursor cells are coded light, middle, and dark grey, respectively. Mature derivatives of the Müllerian compartment and its cervical subcompartment are colored light and dark green, respectively. The color code corresponds to (A). (C) Local cancer fields of cervical carcinoma depicted as red areas in the same midpelvic plane as in (B) for stepwise malignant progression of the transformed cells from ontogenetic stage oT1 to oT4. Modified from Höckel et al.^[15].