fig2

Figure 2. Potential landscape. Potential metastatic urothelial carcinoma (mUC) treatment landscape. Clinical factors which influence treatment selection, such as cisplatin-eligibility, are highlighted in green. Biomarkers are highlighted in yellow. Current FDA-approved treatments are in blue while investigational treatment options are in purple. The combination of chemotherapy and atezolizumab (Chemo-ICI) showed PFS benefits in the IMvigor130 (NCT02807636) trial but OS results are still pending. The combination of enfortumab vedotin with pembrolizumab (EV/P) is being tested in various settings, including first-line against platinum chemotherapy (EV-302, NCT04223856), first-line cisplatin-ineligible (EV-103, NCT03288545), and second-line (EV-103; EV-201, NCT03219333). Other combinations and targeted therapies are under investigation. PD-L1: Programmed death-ligand 1; ICI: immune checkpoint inhibitor; 1L: first-line; 2L: second-line; 3L: third-line.