fig2

Figure 2. Schematic representation of potential MT1-MMP regulatory mechanisms in OS. Several growth factors (including Wnt, PEDF, TGF, EGF) activate downstream signal transduction pathways (including SRC, RAS, PI3K/Akt, Rho/ROCK) that are responsible for the transcriptional regulation of a variety of MMPs, including MT1-MMP. EGF: Epidermal growth factor; ERK: extracellular signal-regulated kinases; PEDF: pigment epithelium-derived factor; PI3K: phosphoinositide 3-kinases; ROCK: Rho-associated protein kinase; SRC: proto-oncogene tyrosine-protein kinase; TGF: transforming growth factor.