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Figure 2. Mediastinal (A-C) and maxillary sinus (D-F) plasmacytomas stained immunohistochemically to visualize microvessel density (MVD) and expression of osteopontin (OPN). On hematoxylin-eosin staining, the poorly differentiated plasma cells can be seen in both extramedullary plasmacytomas (A,D), while immunostaining confirmed high grade of MVD (B,E) and high expression of OPN in plasma cells.