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Figure 2. JQ1 and trametinib synergistically decrease mRNA expression of the MYC gene by attenuating recruitment of BRD4 to the MYC promoter in ATC cells and tumors. (A, B) The mRNA levels of the MYC gene in THJ-11T cells (A-i), -16T cells (B-i), and -11T (A-ii) and -16T xenograft tumors (B-ii). (C) Chromatin immunoprecipitation assays show BRD4 binding on the MYC promoter in THJ-11T (i) and -16T cells (ii). Significant differences were indicated by asterisks (*P < 0.05, **P < 0.01, and ***P < 0.001)^[129]. (Permission from the authors).