fig1

Figure 1. Glycolysis and glycogen metabolism. Glycolytic enzymes and transporters are dysregulated in many forms of thyroid cancer. Bold text for transporters indicates overexpression. Bold arrows indicate increased metabolite flux. Beige circles indicate enzymes not shown to be aberrantly expressed in TC. Red circles display overexpressed enzymes in TC. Inhibitors are outlined in red circles with conjoining red inhibitor (T) bars. Inhibitors in bold have demonstrated efficacy in TC models. Enzyme/transporter key: 1. Hekoxinase; 2. Glucose-6-phosphate isomerase; 3. Phosphofructokinase-1; 4. Aldolase A; 5. Triose phosphate isomerase; 6. Glyceraldehyde-3-phosphate dehydrogenase; 7. Phosphoglycerate kinase 1; 8. Phosphoglycerate mutase; 9. Enolase; 10. Pyruvate kinase; 11. Lactate dehydrogenase, 12. Phosphoglucomutase-1; 13. UDP-glucose pyrophosphorylase 2; 14. Glycogenin; 15. Glycogen synthase 1; 16. Glycogen branching enzyme; 17. Glycogen debranching enzyme; 18. Glycogen phosphorylase. MCT: Monocarboxylate transporter.