fig2

Figure 2. The pentose phosphate pathway. The pentose phosphate pathway is highly active in thyroid cancer. Bold arrows indicate increased metabolite flux. Beige circles indicate enzymes not shown to be aberrantly expressed in TC. Red circles display overexpressed enzymes in TC. Inhibitors are outlined in red circles with conjoining red inhibitor (T) bars. Inhibitors in bold have demonstrated efficacy in TC models. Enzyme key: 1. Glucose-6-phosphate dehydrogenase; 2. 6-Phosphogluconolactonase; 3. 6-Phosphogluconate dehydrogenase; 4. Ribose-5-phosphate isomerase; 5. Ribulose-5-phosphate 3-epimerase; 6. Transketolase; 7. Transaldolase.