fig3

Figure 3. TCA cycle and fatty acid metabolism. The TCA cycle and fatty acid metabolism serve to replenish intermediates for metabolic pathways in thyroid cancer. Bold text for transporters indicates overexpression. Bold arrows indicate increased metabolite flux. Beige circles indicate enzymes not shown to be aberrantly expressed in TC. Red bubbles display overexpressed enzymes in TC. Cyan bubbles indicate mutated or underexpressed enzymes in TC. Inhibitors are outlined in red circles with conjoining red inhibitor (T) bars. Inhibitors in bold have demonstrated efficacy in TC models. Enzyme/transporter key: 1. Pyruvate dehydrogenase; 2. Citrate synthase; 3. Aconitase; 4. Isocitrate dehydrogenase; 5. Alpha ketoglutarate dehydrogenase; 6. Succinyl-CoA synthetase; 7. Succinate dehydrogenase; 8. Fumarase; 9. Malate dehydrogenase 2; 10. Pyruvate carboxylase; 11. Phosphoenolpyruvate carboxykinase 2; 12. ATP-citrate lyase; 13. Malate dehydrogenase 1; 14. Malic enzyme; 15. Acetyl-CoA carboxylase; 16. Fatty acid synthase; 17. Acyl-CoA synthetase; 18. Carnitine palmitoyltransferase 1. CIC: Mitochondrial citrate carrier; CACT: carnitine acylcarnitine translocase; MPC: mitochondrial pyruvate carrier.