fig5

Figure 5. Glutamine metabolism. Thyroid cancer cells overexpress glutamine transporters and enzymes to fuel tumor progression. Bold arrows indicate increased metabolite flux. Beige circles indicate enzymes not shown to be aberrantly expressed in TC. Red circles display overexpressed enzymes in TC. Inhibitors are outlined in red circles with conjoining red inhibitor (T) bars. Inhibitors in bold have demonstrated efficacy in TC models. Enzyme key: 1. Glutaminase; 2. Glutamate dehydrogenase; 3. Aspartate aminotransferase.