fig1
Figure 1. Overview of LPA biosynthesis and receptors. Phospholipase A1 or A2 (PLA1 and PLA2) catabolize membrane phospholipids producing LPA either directly or through the release of LPA precursors (LPC, LPE, and LPS) that are metabolized in LPA by autotaxin (ATX) due to its lysophospholipase D activity. LPA activates six specific G protein-coupled receptors (LPA1-6). LPC: Lysophosphatidylcholine; LPE: lysophosphatidylethanolamine; LPS: lysophosphatidylserine; LPA: lysophosphatidic acid.
