- Prof. Steven N. Fiering
- Microbiology and Immunology at Dartmouth Geisel School of Medicine, Lebanon, NH, USA.
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Special Issue Introduction
The abscopal effect is a hypothesis that describes why sometimes using local treatment to one area of metastatic cancer (such as radiation therapy) may result in cancer shrinking in an untreated area. While this phenomenon was considered rare in the past, it has become more frequent with the advent of immunotherapy drugs such as checkpoint inhibitors to treat cancer. The underlying mechanism for this phenomenon is still unclear, but it is thought that the localized treatment might prime the immune system to attack cancer cells in a distant region. Therefore, JCMT plans to establish a special issue “The Abscopal Effect as a Treatment for Cancer - New Advances” focusing on, but not limited to, the following topics:
1. The abscopal effect in the era of checkpoint inhibitors；
2. The abscopal effect of radiation therapy and the role of DNA damage；
3. Abscopal effect of in situ vaccination and local immunotherapy；
4. Immune pathways mediating the abscopal effect, etc.
Submission Deadline28 Feb 2023