Topic: Strategies in Medical and Surgical Treatment of Metastatic Brain Tumors

Metastatic brain tumors present considerable challenges in neuro-oncology, often resulting in significant morbidity and mortality. Managing metastatic disease necessitates a comprehensive approach that combines systemic treatments, targeted therapies, and surgical interventions. As our understanding of the molecular mechanisms behind metastasis evolves, therapeutic strategies have expanded to include more precise and less invasive modalities.

Among the surgical interventions, techniques such as Laser Interstitial Thermal Therapy (LITT), radiosurgery, and focused ultrasound have gained prominence due to their minimally invasive nature and potential for improved patient outcomes. The decision to employ a particular modality depends on various factors, including tumor type, location, and the patient's overall health.

This Special Issue aims to provide a comprehensive overview of the current landscape of therapies and surgical management in cancer metastasis. We will explore established treatments, delve into emerging techniques, and address the challenges faced in the clinical setting.

Topics to be covered in this Special Issue include:

1. Molecular underpinnings of metastasis;

2. Advancements in targeted therapies for metastatic cancers;

3. Strategies for systemic treatment;

4. Minimally invasive surgical techniques: LITT, radiosurgery, focused ultrasound;

5. Impact of the tumor microenvironment on metastasis;

6. Innovations in metastatic detection through imaging;

7. The role of precision medicine in metastasis treatment;

8. Treating metastatic brain tumors: challenges and progress;

9. Immunotherapeutic approaches for metastatic cancers;

10. Evaluating the efficacy of combination therapies.