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The following list shows the information of planned papers to this special issue. All the papers submitted to Journal of Cancer Metastasis and Treatment will go through a rigorous peer review. (Please note that the information below is provisional and may be subject to future change)
Type of paper: Review article
Tentative Title: Impact of Tumor mutation burden in cancer immunotherapy: Crossroad of tumor biology and immune system
Authors: Yutaka Shio, Yuki Ozaki, Satoshi Muto, Naoyuki Okabe, Takeo Hasegawa, Suzuki Hiroyuki
Affiliation: Department of Chest Surgery, Fukushima Medical University
Rapid progress in the fields both of molecular diagnosis and tumor immunology clearly changed cancer treatment. Profound understandings for tumor immunology contributed cancer immunotherapy mainly in using immune checkpoint inhibitors. On the other hand, clinical genomic analysis brought clinically meaningful effective molecular targeted therapy such as epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and so on. Recent accumulation of these successes make further evolution in tumor biology and immunology. Currently, we are able to apply next generation sequencing (NGS) to clinical use. Representatively, analyzing a tumor mutation burden (TMB) by whole exome sequencing and large cancer panel analysis could be an promising predictive biomarker. TMB is assumed to be closely correlated with tumor neo-antigen frequency and contribute to immune reactiveness of T cells to tumors. In this review, recent update of molecular analysis by using NGS and clinical significance of TMB in immunotherapy will be discussed.
Type of paper: Original article
Tentative Title: A pilot study of distinguishing basal cell carcinoma from normal human skin tissues using resonance Raman spectroscopy from key vibrational biomarkers
Authors: Cheng-hui Liu, Binlin Wu, Laura Sordillo, Chunyuan Zhang, Hugh Beckman, Lin Zhang, Zhe Pei, Lingyan Shi, and Robert R Alfano
Affiliation: Departments of Physics and Electrical Engineering, City University of New York, Institute for Ultrafast Spectroscopy and Lasers, New York, United States
The use of 532 nm provides greater Raman signals from near resonance absorption bands of biomolecules in skin as compared with using an excitation NIR light source. The objectives of this study are to applying Visible Resonant Raman (VRR) spectroscopic technique to find the key molecules peak in VRR spectra fast and distinguish between basal cell carcinoma and healthy human skin using key vibrational biomarkers.
Visible Resonant Raman (VRR) spectroscopic technique offer great speed to measure Raman spectra it been undertaken in this study for basal cell carcinoma and normal human skin tissues using an excitation light source at a wavelength of 532nm. The use of 532 nm provides greater Raman signals from near resonance absorption bands of biomolecules as compared with using an excitation NIR light source.
In this study normal and basal cell carcinoma (BCC) human skin tissue samples were measured using VRR technique, revealing native biomarkers such as tryptophan, carotenoids, lipids and proteins. The VRR spectra from BCC skin cancer samples showed a strong enhancement in proteins including collagen type I combined with amide I and amino acids, and a decrease in carotenoids and lipids. These enhanced molecular fingerprints demonstrate a potential of VRR spectroscopic technique to be a label free molecular pathology method for human skin and other human diseases. A PCA-SVM statistical analysis method based on these molecular fingerprints was developed for differentiating BCC (cancer) from normal skin tissues, from limited sample data yielding a 93.0% diagnostic sensitivity, 100% specificity, and 94.5% accuracy compared with histopathology.
Type of paper: Review article
Tentative Title: Sensitive and specific detection of circulating tumor cells promotes precision medicine for cancer
Authors: Qinqin Huang, Wei Liu, Shi-Shang Guo, Xing-Zhong Zhao
Affiliation: Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
Circulating tumor cells (CTCs) have the potential to provide genetic information for dynamic and heterogeneous tumors, which would be useful for monitoring disease progression and developing personalized therapies. However, the isolation of CTCs for molecular analysis still remains a tremendous challenge due to their extreme rarity and phenotypic heterogeneity, which hinders the transformation of CTC into traditional clinical applications. In order to achieve clinically significant CTC detection, current methods developed using novel microfluidics and nanotechnology have been designed to achieve high sensitivity and specificity capture of CTCs. In this review, we discuss these developed devices for CTC capture and CTC molecular characterization for early diagnose and treatment decision to better manage these cancers clinically. In addition, the potential prognostic values of CTCs as treatment guidelines and that ultimately contribute to realize personalized treatment are also discussed.
Type of paper: Original Article
Tentative Title: Determination of cytokine regulated glycan expression by using molecular imprinted polymers (MIPs) targeting sialic acid
Authors: Llapastica K, Zhang Y, Shinde S, Sellergren B, El-Schich Z, Gjörloff Wingren A.
Affiliation: Biomedical Science, Health and society, Malmö University, Malmö, Sweden
Cancer cells often have an increased amount of glycans, such as sialic acid (SA), on the cell surface, which normally play an important role in cell growth, proliferation and differentiation. In this study, SA expression is determined by fluorescent nanoprobes, molecular imprinted polymers, SA-MIPs. Inflammation and cytokine production are well known tumor promoters, modulating the cellular microenvironment. The recombinant cytokines IL-4, IL-6, IL-8 and a cocktail of cytokines collected from stimulated T leukemia Jurkat cells were used to induce in vitro inflammation in two cell lines, and thereafter analyzed with the use of SA-MIPs and flow cytometry. Both cell lines showed an increased level of sialic acid expression after treatment with IL-4 and with the cytokine cocktail, while treatment with IL-6 and IL-8 downregulated the sialic acid expression. This study shows that SA-MIPs can be an important tool in the investigation of overexpressed glycans in the tumor microenvironment.