- Dr. Rafat A. Siddiqui
- Nutrition Science and Food Chemistry, Agriculture Research Station, Virginia State University, Petersburg, VA, USA.
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Special Issue Introduction
Studies focusing on cancer cell metabolism have opened opportunities to prevent, reduce the tumor growth, attenuate the tumor-associated alteration in tissues and organs, and/or treat different types of cancer. Recent advances in genomics, proteomics, and metabolomics approaches, with availability of more user-friendly Bioinformatics tools, have made it possible to study interactions of biomolecules at a cellular level. Such studies are powerful not only in improving our understating for the dysregulation of metabolic pathways during cancer progression but also offer a unique opportunity to correct these dysregulations. In addition, the effects of dietary compounds on the metabolic and signaling pathways pertinent to cancer metabolism are also currently a topic of great interest. The recent developments have exposed nutrient’s effect at the molecular and cellular level such as agonist/antagonist interaction with cell surface receptors, regulation of enzyme activities, activation/inhibition of signaling pathways, and modulation of gene expression. These findings have provided a new perspective for the altered metabolic pathways in cancer cells in our everyday life situation. The purpose of this special issue is to comprehensively review all the important metabolic alterations in different types of cancer cells in order to design effective approaches for cancer prevention and treatment. We invite authors to submit original research and review articles that address the progress and current understanding of cancer metabolism. Authors can write on any specific cancer metabolic pathway or on the global metabolic changes; however, topics focused on metabolites analysis; intake, absorption and metabolism of nutrients that affect cancer growth; metabolic effects on cell signaling, gene expression; and variation in metabolic enzymes activities due to gene polymorphisms are desired.
Submission Deadline30 Mar 2020