Journal of Cancer Metastasis and Treatment

Topic: Cancer Cell Metabolism

Download All Articles

A special issue of Journal of Cancer Metastasis and Treatment

ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)

Submission deadline: 31 Dec 2018

Guest Editor(s)

Dr. Rafat A. Siddiqui

Nutrition Science and Food Chemistry, Agriculture Research Station, Virginia State University, Petersburg, VA, USA.

Website | E-mail

Special Issue Introduction

Studies focusing on cancer cell metabolism have opened opportunities to prevent, reduce the tumor growth, attenuate the tumor-associated alteration in tissues and organs, and/or treat different types of cancer. Recent advances in genomics, proteomics, and metabolomics approaches, with availability of more user-friendly Bioinformatics tools, have made it possible to study interactions of biomolecules at a cellular level. Such studies are powerful not only in improving our understating for the dysregulation of metabolic pathways during cancer progression but also offer a unique opportunity to correct these dysregulations. In addition, the effects of dietary compounds on the metabolic and signaling pathways pertinent to cancer metabolism are also currently a topic of great interest. The recent developments have exposed nutrient’s effect at the molecular and cellular level such as agonist/antagonist interaction with cell surface receptors, regulation of enzyme activities, activation/inhibition of signaling pathways, and modulation of gene expression. These findings have provided a new perspective for the altered metabolic pathways in cancer cells in our everyday life situation. The purpose of this special issue is to comprehensively review all the important metabolic alterations in different types of cancer cells in order to design effective approaches for cancer prevention and treatment. We invite authors to submit original research and review articles that address the progress and current understanding of cancer metabolism. Authors can write on any specific cancer metabolic pathway or on the global metabolic changes; however, topics focused on metabolites analysis; intake, absorption and metabolism of nutrients that affect cancer growth; metabolic effects on cell signaling, gene expression; and variation in metabolic enzymes activities due to gene polymorphisms are desired.

Submission Deadline

31 Dec 2018

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://jcmtjournal.com/pages/view/author_instructions
For Online Submission, please login at https://oaemesas.com/jcmt
Submission Deadline: 31 Dec 2018
Contacts: Lijun Jin, Managing Editor, editor001@jcmtjournal.com

Published Articles

Open Access Review

Metabolic alterations and the potential for targeting metabolic pathways in the treatment of multiple myeloma

Dustin Rizzieri, ... Yubin Kang

Metabolism is defined as the collection of complex biochemical processes that living cells use to generate energy and maintain their growth and survival. Metabolism encompasses the synthesis and breakdown of glucose, fatty acids, and amino acids; the generation of energy (ATP); and oxidative... Read More >

Metabolism is defined as the collection of complex biochemical processes that living cells use to generate energy and maintain their growth and survival. Metabolism encompasses the synthesis and breakdown of glucose, fatty acids, and amino acids; the generation of energy (ATP); and oxidative phosphorylation. In cancer cells, metabolism can be commandeered to promote tumor growth and cellular proliferation. These alterations in metabolism have emerged as an additional hallmark of various cancers. In this review we focus on metabolic alterations in multiple myeloma (MM) - a malignancy of plasma cells - including derangements in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, oxidative phosphorylation, and fatty acid/amino acid synthesis and degradation. Particular focus is given to metabolic alterations that contribute to myeloma cell growth, proliferation and drug resistance. Finally, novel approaches that target metabolic pathways for the treatment of MM are discussed.
Back >

This article belongs to the Special Issue Cancer Cell Metabolism

J Cancer Metastasis Treat 2019;5:26.

DOI: 10.20517/2394-4722.2019.05

Published on: 3 Apr 2019 Viewed: 301 Downloaded: 69

HTML PDF
Open Access Review

Metabolic rewiring of stem cells and differentiated cells in cancer: the hypothetical consequences of a GABA deficiency in endocrine pancreas

Maurice Israël

The carcinogenic mechanism proposed considers that stem cells committed to repair tissues and differentiated cells, acquire different metabolic properties, if there is an associated GABA deficiency suppressing a control system of the endocrine pancreas. This control system mediated by GABA,... Read More >

The carcinogenic mechanism proposed considers that stem cells committed to repair tissues and differentiated cells, acquire different metabolic properties, if there is an associated GABA deficiency suppressing a control system of the endocrine pancreas. This control system mediated by GABA, released with insulin, normally turns off glucagon and somatostatin release when insulin is released. A consequence of the GABA deficiency in pancreas and adrenals is a hybrid insulin-glucagon-somatostatin message, received by new mitotic stem cells displaying then a hybrid metabolic rewiring. This gives them a selective metabolic advantage over differentiated cells that become insulin resistant and only receive the glucagon- somatostatin part of the hormonal message. Indeed, their insulin receptors are desensitized by the persistent leakage of insulin resulting from the GABA deficiency that fails to close the insulin release mechanism. Thus differentiated cells are simply rewired to be plundered by stem cells. The metabolic advantage gained by stem cells blocks their own differentiation and maintains their mitotic capacity. Inevitable mutations of mitotic cells follow, the immune system is unable to eliminate a geometrically increasing number of altered stem cells, a selection of the most aggressive but metabolically successful population takes place when cancer is declared.
Back >

This article belongs to the Special Issue Cancer Cell Metabolism

J Cancer Metastasis Treat 2019;5:12.

DOI: 10.20517/2394-4722.2018.78

Published on: 27 Feb 2019 Viewed: 213 Downloaded: 35

HTML PDF