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Type: Primary Research article
Title: Proteomic Characterization of Aromatase Inhibitor Resistant Breast Cancer Cells Reveal the Presence of a Novel Nuclear Chaperone
Authors: Karen Gallegos Villalobos1, Jankiben Patel1, Shawn Llopis2, Rashidra R. Walker1, A. Michael Davidson1, Wensheng Zhang3, Kun Zhang3, Syreeta L. Tilghman1
Affiliations: 1Florida A&M University, Division of Basic Sciences, College of Pharmacy, 1415 S. Martin L. King Jr. Blvd, Tallahassee, FL 32307;
2Xavier University of Louisiana, Division of Basic Pharmaceutical Sciences, College of Pharmacy, 1 Drexel Dr., New Orleans, LA 70125;
3Xavier University of Louisiana, Division of Mathematical and Physical Sciences, Department of Computer Science, College of Arts and Sciences, 1 Drexel Dr., New Orleans, LA 70125
Abstract: To understand the mechanisms associated with aromatase inhibitor resistance, a global proteomic analysis was conducted on letrozole resistant breast cancer cells (LTLT-Ca) cultured in suspension as mammospheres and compared to their adherent counterparts. Results demonstrated that LTLT-Ca mammospheres displayed a 35-fold increase in midasin protein expression which correlated to decreased relapse-free survival in ER breast cancer patients. Moreover, midasin protein is ubiquitously expressed in normal tissue, but overexpressed in breast carcinoma tissue and cell lines. Taken together, our results demonstrate that midasin overexpression is positively associated with aromatase inhibitor-resistant breast cancer.
Title: Hormonal and adipose profile of breast cancer patients and metastatic dormancy dynamics
Authors: Danila Coradini1, Romano Demicheli2, Elia Biganzoli1,2
Affiliations: 1Laboratory of Medical Statistics and Epidemiology,“Giulio A. Maccacaro”, Department of Clinical Sciences and Community Health, University of Milan, Via Vanzetti 5, 20133 Milan, Italy.
2Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.
Abstract: Breast cancer is the commonest cancer and leading cause of cancer death in women worldwide, with an estimated 1.7 million cases and over 520,000 deaths in 2012, accounting for 25% of all female cancers and 15% of all female cancer deaths due to distant metastasis. Understanding how the hormonal and adipose profile of breast cancer patients affect the metastatic dormancy dynamics is of paramount importance to prevent distant metastasis awake and spread, and ameliorate the effects of the adjuvant treatment.