Topic: Effect and Role in Epithelial-Mesenchymal Transition in Cancer Metastasis

A special issue of Journal of Cancer Metastasis and Treatment

ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)

Submission deadline: 30 Apr 2020

Guest Editor(s)

  • Hiroshi Tanaka, Prof. Ph.D., Dr.Med.
    Professor Emeritus, Laboratory for promotion of medical data science, School of Medicine, Tokyo Medical and Dental University; Special Adviser to the Executive Director, Specially Appointed Professor, Tohoku Medical Megabank Organization, Tohoku University

    Website | E-mail

Special Issue Introduction

• Mechanisms of EMT programs and cellular plasticity, including breast cancer stem cells
• Mechanisms of metastatic dormancy


EMT, systems biology, genome medicine, complex system, pathway, network

Submission Deadline

30 Apr 2020

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 30 Apr 2020
Contacts: Elaine Gao, managing editor,
Olivia Zhao, assistant editor,

Planned Papers

Type: Primary Research article

Title: Proteomic Characterization of Aromatase Inhibitor Resistant Breast Cancer Cells Reveal the Presence of a Novel Nuclear Chaperone

Authors: Karen Gallegos Villalobos1, Jankiben Patel1, Shawn Llopis2, Rashidra R. Walker1, A. Michael Davidson1, Wensheng Zhang3, Kun Zhang3, Syreeta L. Tilghman1

Affiliations: 1Florida A&M University, Division of Basic Sciences, College of Pharmacy, 1415 S. Martin L. King Jr. Blvd, Tallahassee, FL 32307;
2Xavier University of Louisiana, Division of Basic Pharmaceutical Sciences, College of Pharmacy, 1 Drexel Dr., New Orleans, LA 70125;
3Xavier University of Louisiana, Division of Mathematical and Physical Sciences, Department of Computer Science, College of Arts and Sciences, 1 Drexel Dr., New Orleans, LA 70125

Abstract: To understand the mechanisms associated with aromatase inhibitor resistance, a global proteomic analysis was conducted on letrozole resistant breast cancer cells (LTLT-Ca) cultured in suspension as mammospheres and compared to their adherent counterparts. Results demonstrated that LTLT-Ca mammospheres displayed a 35-fold increase in midasin protein expression which correlated to decreased relapse-free survival in ER breast cancer patients. Moreover, midasin protein is ubiquitously expressed in normal tissue, but overexpressed in breast carcinoma tissue and cell lines. Taken together, our results demonstrate that midasin overexpression is positively associated with aromatase inhibitor-resistant breast cancer.

Type: Review

Title: Hormonal and adipose profile of breast cancer patients and metastatic dormancy dynamics

Authors: Danila Coradini1, Romano Demicheli2, Elia Biganzoli1,2

Affiliations: 1Laboratory of Medical Statistics and Epidemiology,“Giulio A. Maccacaro”, Department of Clinical Sciences and Community Health, University of Milan, Via Vanzetti 5, 20133 Milan, Italy.
2Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.

Abstract: Breast cancer is the commonest cancer and leading cause of cancer death in women worldwide, with an estimated 1.7 million cases and over 520,000 deaths in 2012, accounting for 25% of all female cancers and 15% of all female cancer deaths due to distant metastasis. Understanding how the hormonal and adipose profile of breast cancer patients affect the metastatic dormancy dynamics is of paramount importance to prevent distant metastasis awake and spread, and ameliorate the effects of the adjuvant treatment.

Published Articles

This special issue is now open for submission.