Hot Keywords
Tumor Microenvironment Exosomes and Extracellular Vesicles Breast Cancer Metastasis Bone Metastasis Metastatic Renal Cell Carcinoma Lymph node metastasis Mesothelioma Hematological Malignancies Thyroid Cancer Liquid Biopsies Early Diagnosis Lung Cancer Brain Tumors Lymphoma Oncolytic Virus Cervical Cancer Cancer Stem Cells

Topic: Liquid Biopsies in Cancer Early Diagnosis

A special issue of Journal of Cancer Metastasis and Treatment

ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)

Submission deadline: 31 May 2020

Guest Editor(s)

  • Dr. Wei Zhang
    Department of Preventive Medicine, Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.

    Website | E-mail

Special Issue Introduction

Significant progress in cancer diagnosis and treatment has contributed to improved clinical outcomes for many cancers. However, cancer remains a major health problem around the globe. Early detection of malignant tumors that are still treatable (e.g., surgical removal) is key to lowering cancer-related mortality and improving patient survival. Compared to tissue-based cancer diagnosis approaches that may be limited by for example the issue of tumor heterogeneity, difficulty in obtaining tissue at certain body locations, and possible complications associated with the biopsy procedure, approaches utilizing liquid biopsy (i.e., bodily fluids such as blood, urine, cerebrospinal fluid, saliva, sweat) have been demonstrated as a noninvasive or minimally-invasive, clinically convenient alternative that has been attracting more and more research efforts during the past few years. Specifically, tumor-derived mutational, epigenetic, and transcriptomic features are contained in certain bodily fluids from a patient, thus providing the rationale for developing cancer biomarkers based on these specimens. Furthermore, during the past few years exciting technical advances have emerged to allow profiling various molecular targets in a variety of clinical specimens. In this special issue, we are interested in publishing original articles, reviews, short communications, and technical notes that cover the broad area of cancer early diagnosis using liquid biopsy.


1. Francesca Malentacchi  Clinical Experimental and Biomedical Sciences, University of Florence, Florence, Italy.
2. Ciro Comparetto  Division of Obstetrics and Gynecology, City Hospital, Italy.
3. Stefan Bossmann  Kansas State University, Manhattan, USA.
4. Jian-Ping Wang  Electrical and Computer Engineering, University of Minnesota, Minneapolis, USA.
5. Gerhard Hamilton  Vascular Surgery, Medical University of Vienna, Vienna, Austria.
6. Massimo Cristofanilli  Department of Medicine-Hematology and Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, USA.
7. Gerard J Davis  Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, USA.
8. Danilo Tagle  National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA.
9. Christine Happel  HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Maryland, USA.
10. Masakazu Toi  Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
11. Katharina Pachmann  Medizinisches Labor Pachmann, SIMFO GmbH, Kurpromenade, Germany.
12. Mohammad Amin Kerachian  Cancer Genetics Research Unit, Reza Radiotherapy and Oncology Center, Mashhad, Iran, Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
The list is arranged in no particular order and being updated.


Liquid biopsy, cancer, precision oncology, early diagnosis

Submission Deadline

31 May 2020

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 31 May 2020
Contacts: Elaine Gao, managing editor,
Ivory Ma, assistant editor,

Published Articles

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