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Topic: The Influence of Signaling Pathways in Cancer Treatment

A special issue of Journal of Cancer Metastasis and Treatment

ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)

Submission deadline: 30 Jun 2020

Guest Editor(s)

  • Dr. Andrei Bakin
    Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, United States.

    Website | E-mail

Special Issue Introduction

The introduction is coming soon.


1. Peiwen Fei  University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, USA.
2. Jennifer Grandis  Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, USA.
3. Bogdan Grechko  Plastic and Reconstructive Oncological Urology, National cancer Institute, Ukraine.
4. James A Solomon  University of Central Florida College of Medicine, Orlando, Florida, USA.
5. Consolato Sergi  Stollery Children's Hospital, University of Alberta, Edmonton, Canada.
6. S Balakrishna Pai  Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory School of Medicine, Atlanta, USA.
7. Xiuwei Yang  Department of Pharmacology and Nutritional Sciences, Department of Molecular and Cellular Biochemistry, and Markey Cancer Center, University of Kentucky Lexingto, Lexington, USA.
8. George P. Studzinski  Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, USA.
9. Jennifer R Grandis  Department of Otolaryngology, University of California, San Francisco, USA.
10. Jennifer H Gunter  School of Biomedical Science, Institute of Health & Biomedical Innovation, Queensland University of Technology located within the Translational Research Institute, Brisbane, Australia.
11. Mohamed Hassan  Department of Surgery, Tulane University School of Medicine, New Orleans, USA.
12. Luis Vitetta  The University of Sydney, Faculty of Medicine and Health, Sydney, Australia.
13. Antonella Papa  Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
14. Audrey Minden  Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, USA.
15. Anait S Levenson  Department of Biomedical Sciences, School of Veterinary Medicine, Long Island University, Brookville, USA.
16. Dhimant Desai  Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, United States.
17. Edna Teruko Kimura  Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
18. Karen C Crasta  Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
19. Yihua Wang  Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
20. Ravi P Sahu  Department of Pharmacology and Toxicology, Boonshoft School of Medicine Wright State University, Dayton, USA.
21. Sajeel Chowdhary  Neuro-Oncology Program, Lynn Cancer Institute, Boca Raton, USA.
22. Kelly Grace Magalhaes  Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Distrito Federal, Brazil.
23. Shanta M Messerli  Department of Biomedical Engineering, University of South Dakota, Sioux Falls, USA.
The list is arranged in no particular order and being updated.

Submission Deadline

30 Jun 2020

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 30 Jun 2020
Contacts: Monica Gao, assistant editor,

Planned Papers

Type: Original Article

Title: Cellular signaling pathways activated by α-Mangostin during induction of cell death in human esophageal adenocarcinoma

Authors: S. Balakrishna Pai

Affiliations: Director of Instructional Laboratories,Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University.

Abstract: Aim: Alpha mangostin, a xanthone from mangosteen fruit, has been reported to have beneficial effects against various cancers. However, the potential of this molecule against esophageal adenocarcinoma has not been investigated in detail. The current study sought to investigate the cytotoxic effect of α-mangostin on the esophageal carcinoma cell line OE33 as well as elucidate the mechanism of action.
Methods: A Cell Counting Kit-8 assay was used to assess the cell viability after treatment with α-mangostin. Additionally, multicaspase, cell cycle, and mitopotential flow cytometric assays were also performed to further assess the contribution of various signaling pathways on α-mangostin-induced cell death of OE33 cells.
Results: Cell Counting Kit-8 assay indicated that cell viability was significantly reduced in a dose-dependent manner after 72 hours of α-mangostin treatment. After assessing the cells via an Annexin V & Dead Cell Kit at 24, 48, and 72 hours, it was determined that OE33 cells underwent early apoptosis after only 24 hours of treatment at a concentration of 15 µM. α-mangostin treatment did not significantly change the mitochondrial potential nor did it impact the cell cycle progression. Further, detailed analysis of apoptosis signaling pathway indicated that caspase cascade could be responsible for reduction in cell viability of treated cells. α-mangostin induces apoptosis at an early timepoint in OE33 cells and does so at a relatively low concentration.
Conclusion: Taken together, data from the current study, in addition to deciphering the signaling pathways, highlight the potential therapeutic potential of α-mangostin against esophageal adenocarcinoma.

Published Articles

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