- Iola Melissa Fernandes Duarte
- Principal Researcher, CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal
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- Ana Maria Pissarra Coelho Gil
- Associate Professor with Habilitation, CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal
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Special Issue Introduction
Metabolomics, the most recent entry in the omics universe, entails the comprehensive measurement of small molecules in biological samples and of their fluctuations upon pathophysiological alterations or external stimuli. Cancer research is one of the fields where metabolomics has been more extensively applied, concomitantly with the rising appreciation of metabolic reprogramming as a key enabling cancer hallmark. Cancer metabolomics has already allowed several candidate diagnostic biomarkers to be identified in tumor biopsies, as well as in surrounding or circulating body fluids. Additionally, metabolic signatures have been correlated with disease stages and response to treatment. Still, great challenges remain in this respect, such as establishing the specificity of metabolic markers and validating their utility in clinical practice. Metabolomics is also proving useful to help elucidating oncogenic mechanisms and their molecular links to cellular metabolic pathways. Indeed, with metabolites being increasingly perceived as bioactive molecules capable of influencing tumorigenesis and disease progression, metabolomics approaches, including stable isotope-resolved metabolomics, emerge as uniquely valuable tools in mechanistic discoveries, especially when combined with other biological assays and computational methods.
For this Special Issue, we would like to invite research and/or review papers which address the application of metabolomics in cancer research, from biomarker identification and validation to bioactivity screening and targeted mechanistic studies. Works focusing on recent analytical and bioinformatics advances, as well as on integration with other omics data, are also welcome.
KeywordsMetabolomics; Cancer; Tumour metabolism; Biomarkers; Oncometabolites; NMR spectroscopy; Mass spectrometry; Stable isotope-assisted metabolomics; Bioinformatics.
Submission Deadline31 Aug 2020