Topic: Bone and Soft Tissue Tumors

A special issue of Journal of Cancer Metastasis and Treatment

ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)

Submission deadline: 31 Aug 2020

Guest Editor(s)

  • Prof. Ian Judson
    SOS Desmoid & Sarcoma Patients EuroNet (SPAEN), UK.

    Website | E-mail

Submission Deadline

31 Aug 2020

Submission Information

Articles of special issue are free of charge for article processing.
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Submission Deadline: 31 Aug 2020
Contacts: Olivia Zhao, Assistant Editor,

Planned Papers

Type: Review

Title: Current status of molecular testing for the diagnosis of bone tumors

Authors: David Suster1, Saul Suster2

Affiliations: 1Mount Sinai Medical Center and Icahn School of Medicine, New York, NY 10029, USA.
2Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Abstract: Genetic events have been increasingly found to play a pivotal role in the process of carcinogenesis in bone and soft tissue tumors.  In recent years, numerous advances have been made in the characterization of some of the molecular alterations involved in the histogenesis of bone tumors. Such findings play a significant role in the diagnosis and characterization of such lesions. In addition to serving to confirm the diagnosis in difficult or equivocal cases, they may also have some bearing for the prognosis and management of these patients, particularly in this era of personalized medicine in which specific treatment plans can be devised with the use of targeted therapies. This review will explore the principal new findings in the field of molecular genetics of bone tumors and their current impact on the management of these patients.

Type: Research Article

Title: Multiplexed bioluminescence imaging of cancer cell response to hypoxia and inflammation in a bone metastasis mouse model during treatment with zoledronic acid

Authors: Shinae Kizaka-Kondoh

Affiliations: School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

Abstract: Therapeutic agents suppressing bone remodeling have been clinically approved to delay metastatic progression and skeletal-related events in patients with bone metastasis. However, the therapeutic agents including zoledronic acid (ZA) are insufficient to regress established bone metastasis. Therefore, new treatment strategies are desired, and elucidating the status of metastatic bone cancer cells during metastatic progression can help develop strategies. Here, we have developed a unique multiplexed bioluminescence reporter system (MRS) by using three luciferase reporter genes, which allows noninvasive, quantitative and long-term monitoring of tumor growth and the activities of NF-κB and hypoxia-inducible factor (HIF), key transcriptional factors in response to inflammation and hypoxia, respectively. PC-3/MRS, a human prostate cancer cell line that stably retains MRS, was applied to an intra-caudal artery injection bone metastasis model using immune-deficient mice. We demonstrated long-term (< 1 month) noninvasive monitoring of MRS signals emanating from bone metastasis in hind limbs. In addition, MRS imaging revealed that ZA treatment suppresses NF-κB and HIF activities as well as the growth of bone metastasis. Taken together, MRS successfully visualized activities of NF-κB and HIF in PC-3/MRS in bones and could be a powerful tool to develop new therapeutic strategies for bone metastasis.

Type: Review

Title: Photodynamic therapy as an alternative tool against osteosarcoma: concepts and recent advances

Authors: Lucas D. Dias1, Júlia M. Veronese2

Affiliations: 1São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
2Faculty of Medicine, University of Gurupi, Gurupi, Brazil.

Abstract: Osteosarcoma is one of the most common primary malignancies of bone in childhood and adolescence. This disease shows a poor prognosis for patients with metastatic or recurrent disease (survival < 20%). In this sense, a novel approach to treat this disease has been evaluated, namely, photodynamic therapy. This alternative and efficient therapeutic tool is based on use of a photosensitizing molecule, molecular oxygen, and an appropriate source light yielding oxidative species able to combat cancer cells. In this review, some of the important biochemical and clinical events involved in osteosarcoma as well as concepts and clinical applications of photodynamic therapy will be reported and discussed. Moreover, we review the last 5 years (2015-2019) regarding the application of photodynamic therapy against osteosarcoma.

Type: Article

Title: Phosphoinositide signal transduction pathway and osteosarcoma metastases

Authors: Vincenza Rita Lo Vasco

Affiliations: Morphology Section, Department of Biomedical, Metabolic Sciences and Neuroscience, University of Modena and Reggio Emilia, Modena, Italy.

Abstract: Metastasis spreading confers worse prognosis to the clinical outcome in patients affected with osteosarcoma, the most common primary bone tumour in childhood and adolescence. The identification of the molecules involved in spreading might help to understand the mechanisms of tumour dissemination, opening the way to novel therapeutic strategies. The activation of ezrin-radixin-moesin (ERM) family proteins was proposed to occur after interaction with molecules belonging to Phosphoinositide signal transduction pathway. The Phosphatydil inositol (4,5) bisphosphate (PIP2), a crucial molecule in PI pathway, was indicated to be involved in the stabilization of ERM proteins or a more efficient receptor binding. The levels of PIP2 in the pathway represent a critical element for regulation of a number of cell events. PIP2 levels are regulated by means of enzymes, including the PI-specific Phospholipase C family. The reduction of PIP2 levels induces ERM protein dissociation from the membrane. PI-PLC enzymes contribute to regulate this event (Brown 2001). The role of PI signal transduction molecules in osteosarcoma metastases will be discussed.

Type: Review

Title: Proximal humeral reconstructive options in orthopedic oncology

Authors: Sridhar Pinnamaneni, Timothy A. Damron

Affiliations: Department of Orthopedic Surgery, Upstate Medical University, Upstate Bone and Joint Center, East Syracuse, NY 13057, USA.

Abstract: Proximal humeral reconstructive options following radical resection of proximal humeral primary and metastatic bone malignancies have evolved over time. With the relatively recent advent of the reverse total shoulder arthroplasty (rTSA), this technique has been increasingly employed in this setting over hemi-arthroplasty techniques. An array of options, including proximal humeral allograft-prosthetic composites (including both rTSA and hemi's), megaprostheses, and osteoarticular allografts will be reviewed from the perspective of their indications, techniques, complications, and published results. An extensive case-based pictorial presentation will illustrate these options.

Published Articles

This special issue is now open for submission.